Zobrazeno 1 - 10
of 336
pro vyhledávání: '"Nir Friedman"'
Autor:
Haiyue Liu, Roberto Arsiè, Daniel Schwabe, Marcel Schilling, Igor Minia, Jonathan Alles, Anastasiya Boltengagen, Christine Kocks, Martin Falcke, Nir Friedman, Markus Landthaler, Nikolaus Rajewsky
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 10, Pp 1-23 (2023)
Abstract RNA abundance is tightly regulated in eukaryotic cells by modulating the kinetic rates of RNA production, processing, and degradation. To date, little is known about time-dependent kinetic rates during dynamic processes. Here, we present SLA
Externí odkaz:
https://doaj.org/article/25cb9d37b1464e73a48853d888e495de
Autor:
Miriam I. Rosenberg, Erez Greenstein, Martin Buchkovich, Ayelet Peres, Eric Santoni-Rugiu, Lei Yang, Martin Mikl, Zalman Vaksman, David L. Gibbs, Dan Reshef, Amy Salovin, Meredith S. Irwin, Arlene Naranjo, Igor Ulitsky, Pedro A. de Alarcon, Katherine K. Matthay, Victor Weigman, Gur Yaari, Jessica A. Panzer, Nir Friedman, John M. Maris
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112879- (2023)
Summary: Neuroblastoma is a lethal childhood solid tumor of developing peripheral nerves. Two percent of children with neuroblastoma develop opsoclonus myoclonus ataxia syndrome (OMAS), a paraneoplastic disease characterized by cerebellar and brainst
Externí odkaz:
https://doaj.org/article/506516905d124cd99326d2bc5f05f4f1
Autor:
Bayan Mashahreh, Shir Armony, Kristoffer Enøe Johansson, Alon Chappleboim, Nir Friedman, Richard G. Gardner, Rasmus Hartmann-Petersen, Kresten Lindorff-Larsen, Tommer Ravid
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
How misfolded proteins are selected by the ubiquitin-conjugating system for elimination is largely unknown. Here, the authors identify conserved features of proteome-derived degradation signals, including amino acid and structural preferences, that t
Externí odkaz:
https://doaj.org/article/cf7027894a32433c80084976497c6a94
Autor:
Michal Mark, Shlomit Reich-Zeliger, Erez Greenstein, Adi Biram, Benny Chain, Nir Friedman, Asaf Madi
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The T cell receptor is generated by a process of random and imprecise somatic recombination. The number of possible T cell receptors which this process can produce is enormous, greatly exceeding the number of T cells in an individual. Thus, the likel
Externí odkaz:
https://doaj.org/article/5ac08b95eb704f838509dfccf648665c
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
A major challenge in developing an effective adoptive cancer immunotherapy is the ex-vivo generation of tumor-reactive cells in sufficient numbers and with enhanced cytotoxic potential. It was recently demonstrated that culturing of activated murine
Externí odkaz:
https://doaj.org/article/96cb62cf91db4e359ddc8317e97d3904
Autor:
Francesco Camaglia, Arie Ryvkin, Erez Greenstein, Shlomit Reich-Zeliger, Benny Chain, Thierry Mora, Aleksandra M Walczak, Nir Friedman
Publikováno v:
eLife, Vol 12 (2023)
One of the feats of adaptive immunity is its ability to recognize foreign pathogens while sparing the self. During maturation in the thymus, T cells are selected through the binding properties of their antigen-specific T-cell receptor (TCR), through
Externí odkaz:
https://doaj.org/article/a2c93bda44ab45a9909f76857e4c2dc8
Autor:
Avishai Gavish, Benny Chain, Tomer M. Salame, Yaron E. Antebi, Shir Nevo, Shlomit Reich-Zeliger, Nir Friedman
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105826- (2023)
Summary: Numerous methods have recently emerged for ordering single cells along developmental trajectories. However, accurate depiction of developmental dynamics can only be achieved after rescaling the trajectory according to the relative time spent
Externí odkaz:
https://doaj.org/article/7fc9395b64ad45d9a7910ff3206b36d0
Publikováno v:
Heliyon, Vol 8, Iss 12, Pp e12473- (2022)
Objectives: There is a low rate of body mass index measurements and obesity screening in primary pediatric care. Pediatric emergency department (PED) visits, with their large volumes and routine weight measurements, provide a unique opportunity to id
Externí odkaz:
https://doaj.org/article/ea702bb551cc45bb9f04af3b3431cd25
Autor:
Michal Mark, Shlomit Reich-Zeliger, Erez Greenstein, Dan Reshef, Asaf Madi, Benny Chain, Nir Friedman
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
We systematically examine the receptor repertoire in T cell subsets in young, adult, and LCMV-infected mice. Somatic recombination generates diversity, resulting in the limited overlap between nucleotide sequences of different repertoires even within
Externí odkaz:
https://doaj.org/article/d825fa55e5c2498f9627bcbbab94f7e2
Autor:
Ivan Haralampiev, Simon Prisner, Mor Nitzan, Matthias Schade, Fabian Jolmes, Max Schreiber, Maria Loidolt-Krüger, Kalle Jongen, Jasmine Chamiolo, Niklaas Nilson, Franziska Winter, Nir Friedman, Oliver Seitz, Thorsten Wolff, Andreas Herrmann
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The mechanism underlying packaging of the 8 segments of the influenza virus genome into virions is not well understood. Here, the authors use a multiplexed FISH assay to monitor the 8 segments in parallel in infected cells suggesting bundling routes
Externí odkaz:
https://doaj.org/article/e9becb9151bc493e9ef5fd9a997edb31