Serum biomarker gMS-Classifier2: predicting conversion to clinically definite multiple sclerosis.

Autor: Georgina Arrambide, Carmen Espejo, Jennifer Yarden, Ella Fire, Larissa Spector, Nir Dotan, Avinoam Dukler, Alex Rovira, Xavier Montalban, Mar Tintore

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e59953 (2013)

BackgroundAnti-glycan antibodies can be found in autoimmune diseases. IgM against glycan P63 was identified in clinically isolated syndromes (CIS) and included in gMS-Classifier2, an algorithm designed with the aim of identifying patients at risk of

Externí odkaz: https://doaj.org/article/642ff7eaad4f4f0ca1d633309f68b14c

Creation of a gene expression classifier for predicting Parkinson's disease rate of progression

Autor: Moussa B.H. Youdim, Peter Riederer, Jennifer Yarden, Jose Martin Rabey, Danit Mechlovich, Nir Dotan

Publikováno v: Rabey, J M, Yarden, J, Dotan, N, Mechlovich, D, Riederer, P & Youdim, M B H 2020, ' Creation of a gene expression classifier for predicting Parkinson’s disease rate of progression ', Journal of Neural Transmission, vol. 127, no. 5, pp. 755-762 . https://doi.org/10.1007/s00702-020-02194-y

Parkinson’s disease (PD) etiology is heterogeneous, genetic, and multi-factorial, resulting in a varied disease from a mild slow progression to a more severe rapid progression. Prognostic information on the nature of the patient’s disease at diag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaada4074f8fb6c755cbd1136e58084f
https://pubmed.ncbi.nlm.nih.gov/32385576

Serum anti-glycan antibodies predict complicated Crohnʼs disease behavior

Autor: Andrea Dirmeier, Frank Klebl, Jennifer Yarden, Florian Rieder, Rocio Lopez, Nir Dotan, Alexandra Wolf, Larissa Spector, Stephan Schleder, Florian Obermeier, Gerhard Rogler, Ulrike Strauch, Ella Fire

Publikováno v: Inflammatory Bowel Diseases. 16:1367-1375

Background: A high proportion of patients with Crohn's disease (CD) over time develop complications like fistulae and strictures, requiring surgery. We tested a panel of antiglycan antibodies for predicting the occurrence of complications and CD-rela

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317abc37ffdeace7752088a4db881e79
https://doi.org/10.1002/ibd.21179

Serum anti-GAGA4 IgM antibodies differentiate relapsing remitting and secondary progressive multiple sclerosis from primary progressive multiple sclerosis and other neurological diseases

Autor: Hayrettin Tumani, Nir Dotan, Dee Husebye, Jennifer Yarden, Johannes Brettschneider, Ella Fire, Troy D. Jaskowski, Sana Abdul, Larissa Spector, John W. Rose, Haniah Seraj, Harry R. Hill

Publikováno v: Journal of Neuroimmunology. 217:95-101

The serum level of IgM antibodies against Glc(α1,4)Glc(α) (GAGA4) is higher in relapsing remitting multiple sclerosis (RRMS) compared to other neurological disease (OND) patients and healthy controls (HC). Detecting the level of anti-GAGA4 antibody

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36a22c0e01c3bb0a6444bd27f16153f7
https://doi.org/10.1016/j.jneuroim.2009.07.017

Antibodies Against Laminaribioside and Chitobioside Are Novel Serologic Markers in Crohn’s Disease

Autor: Avi Shtevi, Zamir Halpern, Aaron Lerner, Iris Dotan, Yaara Dgani, Mikael Schwartz, Sigal Fishman, Rom T. Altstock, Amir Karban, Larissa Spector, Oori Weishauss, Nir Dotan

Publikováno v: Gastroenterology. 131:366-378

New serologic markers of inflammatory bowel disease may be useful for differentiating between Crohn's disease and ulcerative colitis and for disease stratification. We profiled sugar-binding antibodies to identify novel antiglycan antibodies that may

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e6787ca16c1f70d442aca3aa06999c6
https://doi.org/10.1053/j.gastro.2006.04.030