Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Nir, London"'
Autor:
Danielle Algranati, Roni Oren, Bareket Dassa, Liat Fellus-Alyagor, Alexander Plotnikov, Haim Barr, Alon Harmelin, Nir London, Guy Ron, Noa Furth, Efrat Shema
Publikováno v:
eLife, Vol 13 (2024)
Diffuse midline gliomas (DMGs) are aggressive and fatal pediatric tumors of the central nervous system that are highly resistant to treatments. Lysine to methionine substitution of residue 27 on histone H3 (H3-K27M) is a driver mutation in DMGs, resh
Externí odkaz:
https://doaj.org/article/d63328b5980f4190895f7d76cb98e2cf
Autor:
Ronen Gabizon, Barr Tivon, Rambabu N. Reddi, Maxime C. M. van den Oetelaar, Hadar Amartely, Peter J. Cossar, Christian Ottmann, Nir London
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Peptide-based covalent probes can target shallow protein surfaces not typically addressable using small molecules, yet there is a need for versatile approaches to convert native peptide sequences into covalent binders that can target a broad
Externí odkaz:
https://doaj.org/article/5aae5785bf5a4414ad69a7fd79733088
Autor:
Alice Douangamath, Daren Fearon, Paul Gehrtz, Tobias Krojer, Petra Lukacik, C. David Owen, Efrat Resnick, Claire Strain-Damerell, Anthony Aimon, Péter Ábrányi-Balogh, José Brandão-Neto, Anna Carbery, Gemma Davison, Alexandre Dias, Thomas D. Downes, Louise Dunnett, Michael Fairhead, James D. Firth, S. Paul Jones, Aaron Keeley, György M. Keserü, Hanna F. Klein, Mathew P. Martin, Martin E. M. Noble, Peter O’Brien, Ailsa Powell, Rambabu N. Reddi, Rachael Skyner, Matthew Snee, Michael J. Waring, Conor Wild, Nir London, Frank von Delft, Martin A. Walsh
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
The SARS-CoV-2 main protease is an important target for the development of COVID-19 therapeutics. Here, the authors combine X-ray crystallography and mass spectrometry and performed a large scale fragment screening campaign, which yielded 96 liganded
Externí odkaz:
https://doaj.org/article/d499338758524d99942f9963faf75661
Autor:
Yamit Shorer Arbel, Ben-Zion Katz, Ronen Gabizon, Amit Shraga, Yotam Bronstein, Talia Kamdjou, Anat Globerson Levin, Chava Perry, Irit Avivi, Nir London, Yair Herishanu
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Proteolysis targeting chimeras (PROTACs) are small molecules that form ternary complexes between their target and E3 ligase, resulting in ubiquitination and proteasomal degradation of the target protein. Using our own designed Bruton’s tyrosine kin
Externí odkaz:
https://doaj.org/article/650b70fb17db4836a1e4c93f379c112c
Sulfamate Acetamides as Self-Immolative Electrophiles for Covalent Ligand-Directed Release Chemistry
Autor:
Rambabu N. Reddi, Adi Rogel, Ronen Gabizon, Dattatraya Gautam Rawale, Battu Harish, Shir Marom, Barr Tivon, Yamit Shorer Arbel, Neta Gurwicz, Roni Oren, Keren David, Jingjing Liu, Shirly Duberstein, Maxim Itkin, Sergey Malitsky, Haim Barr, Ben-Zion Katz, Yair Herishanu, Idit Shachar, Ziv Shulman, Nir London
Publikováno v:
Journal of the American Chemical Society. 145:3346-3360
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f436a11b4b6322b7627191f360644f7
https://doi.org/10.1021/jacs.2c08853
https://doi.org/10.1021/jacs.2c08853
Autor:
Jingxu Guo, Alice Douangamath, Weixiao Song, Alun R. Coker, A.W. Edith Chan, Steve P. Wood, Jonathan B. Cooper, Efrat Resnick, Nir London, Frank von Delft
Publikováno v:
Journal of Structural Biology: X, Vol 4, Iss , Pp 100031- (2020)
Outbreaks of human epidemic nonbacterial gastroenteritis are mainly caused by noroviruses. Viral replication requires a 3C-like cysteine protease (3CLpro) which processes the 200 kDa viral polyprotein into six functional proteins. The 3CLpro has attr
Externí odkaz:
https://doaj.org/article/f7ec49afe3444088a8e5ae5ef622317b
Autor:
Paul Gehrtz, Shir Marom, Mike Bührmann, Julia Hardick, Silke Kleinbölting, Amit Shraga, Christian Dubiella, Ronen Gabizon, Jan N. Wiese, Matthias P. Müller, Galit Cohen, Ilana Babaev, Khriesto Shurrush, Liat Avram, Efrat Resnick, Haim Barr, Daniel Rauh, Nir London
Publikováno v:
Journal of Medicinal Chemistry. 65:10341-10356
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b2be7b4def52ba1c783732d2be56919
https://doi.org/10.1021/acs.jmedchem.1c02206
https://doi.org/10.1021/acs.jmedchem.1c02206
Autor:
William McCorkindale, Nir London
Publikováno v:
Proceedings of the National Academy of Sciences. 120
A common challenge in drug design pertains to finding chemical modifications to a ligand that increases its affinity to the target protein. An underutilized advance is the increase in structural biology throughput, which has progressed from an artisa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3da4e549dde6fb5c7ecc9baee22e581a
https://doi.org/10.1073/pnas.2214168120
https://doi.org/10.1073/pnas.2214168120
Autor:
Daniel S. Bejan, Sunil Sundalam, Haihong Jin, Rory K. Morgan, Ilsa T. Kirby, Ivan R. Siordia, Barr Tivon, Nir London, Michael S. Cohen
Publikováno v:
Chemical Science. 13:13898-13906
PARP16-the sole ER-resident PARP family member-is gaining attention as a potential therapeutic target for cancer treatment. Nevertheless, the precise function of the catalytic activity of PARP16 is poorly understood. This is primarily due to the lack
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::303d284d4e105033c320f5f7e56e5083
https://doi.org/10.1039/d2sc04820e
https://doi.org/10.1039/d2sc04820e
Autor:
Roeland Vanhoutte, Marta Barniol-Xicota, Winston Chiu, Laura Vangeel, Dirk Jochmans, Steven De Jonghe, Hadeer Zidane, Haim M. Barr, Nir London, Johan Neyts, Steven H. L. Verhelst
The COVID-19 pandemic has revealed the vulnerability of the modern, global society. With expected waves of future infections by SARS-CoV-2, treatment options for infected individuals will be crucial in order to decrease mortality and hospitalizations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2386255ad9ab798498e387ff288f5fc6
