Výsledky vyhledávání - "Nipun Mistry"

Additional file 1: Table S3. of p53 deficiency linked to B cell translocation gene 2 (BTG2) loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in patient-derived xenograft (PDX) models of triple-negative breast cancer

Autor: Powell, Emily, Jiansu Shao, Yuan, Yuan, Hsiang-Chun Chen, Shirong Cai, Echeverria, Gloria, Nipun Mistry, Decker, Keith, Schlosberg, Christopher, Kim-Anh Do, Edwards, John, Liang, Han, Piwnica-Worms, David, Piwnica-Worms, Helen

Mini-signature of genes that interact with the p53 pathway and associated p values. (PDF 62 kb)

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Additional file 3: Figure S2. of p53 deficiency linked to B cell translocation gene 2 (BTG2) loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in patient-derived xenograft (PDX) models of triple-negative breast cancer

p53 silencing does not increase number of tumor-initiating cells. (A and B) Limiting numbers of BC3-p53WT or BC3-p53KD were implanted to mouse mammary fat pads, and tumor presence and growth was assessed with BLI. Limiting dilution transplantation as

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Additional file 7: Table S2. of p53 deficiency linked to B cell translocation gene 2 (BTG2) loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in patient-derived xenograft (PDX) models of triple-negative breast cancer

Pathway analysis of RNA-Seq expression signature consisting of genes deregulated upon p53 knockdown. (PDF 63 kb)

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Additional file 5: Figure S4. of p53 deficiency linked to B cell translocation gene 2 (BTG2) loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in patient-derived xenograft (PDX) models of triple-negative breast cancer

CTC number correlates with mammary tumor size. Mouse mammary fat pads were engrafted with BC3-p53WT or BC3-p53KD. Whole blood was extracted from mice in a terminal blood draw by cardiac puncture. Red blood cells were lysed, and circulating tumor cell

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Additional file 4: Figure S3. of p53 deficiency linked to B cell translocation gene 2 (BTG2) loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in patient-derived xenograft (PDX) models of triple-negative breast cancer

p53 silencing increases growth at metastatic sites. BC3-p53WT or BC3-p53KD cells were injected to the left cardiac ventricle (A, p = 0.22 at 4 weeks; p = 0.01 at 6 weeks)) or tail vein (B, p = 0.03 at 13 weeks), and mice were subjected to BLI in vivo

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Additional file 8: Figure S5. of p53 deficiency linked to B cell translocation gene 2 (BTG2) loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in patient-derived xenograft (PDX) models of triple-negative breast cancer

Ectopic expression of BTG2 in BC3-p53KD cells reduces cell proliferation in vitro. BC3-p53KD cells were stably transduced with plasmids encoding BTG2 or GFP (control). mRNA (A) and protein (B) levels of BTG2 were determined by qRT-PCR and Western blo

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Additional file 6: Table S1. of p53 deficiency linked to B cell translocation gene 2 (BTG2) loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in patient-derived xenograft (PDX) models of triple-negative breast cancer

RNA-Seq signature of genes that are deregulated upon p53 loss in BC3 mammary tumors. (PDF 123 kb)

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