Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Nipun Jayachandran"'
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
Immunopathological outcomes in Systemic Lupus Erythematosus (SLE; or lupus) are believed to be autoantibody-mediated. Conditions which promote a Th2 skew (such as pregnancy) should encourage antibody production, worsening antibody-mediated diseases w
Externí odkaz:
https://doaj.org/article/4c1d71dee332492aaa339d2f886259c0
Autor:
Jude E. Uzonna, Folayemi Olayinka-Adefemi, Sen Hou, Chukwunonso Onyilagha, Aaron J. Marshall, Nipun Jayachandran, Ping Jia
Publikováno v:
The Journal of Immunology. 207:1401-1410
PI3Kδ is critical in generating humoral and regulatory immune responses. In this study, we determined the impact of PI3Kδ in immunity to Trypanosoma congolense, an African trypanosome that can manipulate and evade Ab responses critical for protecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ded8270cba759e0684aa7909c2f7a7bf
https://doi.org/10.4049/jimmunol.2100311
https://doi.org/10.4049/jimmunol.2100311
Autor:
Michelle D Cully, Yinling Hu, Michael P. Cancro, Nipun Jayachandran, Ellen Puré, Michael J. May, Bruce D. Freedman, Jorge I. Alvarez, James Monslow, Jacquelyn Freund-Brown, Kelly A. McCorkell, Tiffany Weinkopff
Publikováno v:
Proc Natl Acad Sci U S A
Global inactivation of IκB kinase (IKK)-α results in defective lymph node (LN) formation and B cell maturation, and loss of IKK-α–dependent noncanonical NF-κB signaling in stromal organizer and hematopoietic cells is thought to underlie these d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e0273640f68b217d3db0ba0668cb0c
https://pubmed.ncbi.nlm.nih.gov/34810256
https://pubmed.ncbi.nlm.nih.gov/34810256
Autor:
Chukwunonso Onyilagha, Ping Jia, Nipun Jayachandran, Sen Hou, Ifeoma Okwor, Shiby Kuriakose, Aaron Marshall, Jude E Uzonna
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 4, p e0003716 (2015)
BACKGROUND:Bam32, a 32 kDa adaptor molecule, plays important role in B cell receptor signalling, T cell receptor signalling and antibody affinity maturation in germinal centres. Since antibodies against trypanosome variant surface glycoproteins (VSG)
Externí odkaz:
https://doaj.org/article/e8ed02194b374b06ae610fcb26a22859
Autor:
Folayemi, Olayinka-Adefemi, Chukwunonso, Onyilagha, Nipun, Jayachandran, Sen, Hou, Ping, Jia, Jude, Uzonna, Aaron J, Marshall
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 207(5)
PI3Kδ is critical in generating humoral and regulatory immune responses. In this study, we determined the impact of PI3Kδ in immunity to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6d052c8234fb1f24c3c561e04b10bebe
https://pubmed.ncbi.nlm.nih.gov/34380646
https://pubmed.ncbi.nlm.nih.gov/34380646
Autor:
Aaron J. Marshall, Affan A. Sher, Kimia Sheikholeslami, Nipun Jayachandran, Edgard M. Mejia, Grant M. Hatch, Sen Hou
Publikováno v:
The Journal of Immunology. 201:406-416
Class I PI3K enzymes play critical roles in B cell activation by phosphorylating plasma membrane lipids to generate two distinct phosphoinositide (PI) products, PI(3,4,5)P3 and PI(3,4)P2. These PIs each bind distinct but overlapping sets of intracell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a5f7712c309022d32144473dd33e9dc
https://doi.org/10.4049/jimmunol.1701440
https://doi.org/10.4049/jimmunol.1701440
Publikováno v:
European Journal of Immunology. 47:280-290
Control of B-cell signal transduction is critical to prevent production of pathological autoantibodies. Tandem PH domain containing proteins (TAPPs) specifically bind PI(3,4)P2, a phosphoinositide product generated by PI 3-kinases and the phosphatase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6effb82c1a4076ffd09870ab5fd1323
https://doi.org/10.1002/eji.201646596
https://doi.org/10.1002/eji.201646596
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
Frontiers in Endocrinology
Frontiers in Endocrinology
Immunopathological outcomes in Systemic Lupus Erythematosus (SLE; or lupus) are believed to be autoantibody-mediated. Conditions which promote a Th2 skew (such as pregnancy) should encourage antibody production, worsening antibody-mediated diseases w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e597c7eecfd84a86de2f7e0a444e9b4d
https://www.frontiersin.org/article/10.3389/fendo.2018.00742/full
https://www.frontiersin.org/article/10.3389/fendo.2018.00742/full
Autor:
Folayemi Olayinka-Adefemi, Chukwunonso Onyilagha, Nipun Jayachandran, Sen Hou, Ping Jia, Jude E Uzonna, Aaron J Marshall
Publikováno v:
The Journal of Immunology. 204:82.39-82.39
The delta isoform of PI 3-kinase (PI3Kδ) has important functions in B cell activation. Trypanosoma parasites utilize several mechanisms to exploit and evade host B cell and antibody responses critical for immunity. We sought to determine the impact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0279e6fc682d5c44fbf7c9257629c95
https://doi.org/10.4049/jimmunol.204.supp.82.39
https://doi.org/10.4049/jimmunol.204.supp.82.39
Publikováno v:
European journal of immunology. 47(2)
Control of B-cell signal transduction is critical to prevent production of pathological autoantibodies. Tandem PH domain containing proteins (TAPPs) specifically bind PI(3,4)P2, a phosphoinositide product generated by PI 3-kinases and the phosphatase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e9a82f02d090283e2adaab54f84b87a9
https://pubmed.ncbi.nlm.nih.gov/27859053
https://pubmed.ncbi.nlm.nih.gov/27859053