Zobrazeno 1 - 10
of 392
pro vyhledávání: '"Nipavan Chiamvimonvat"'
Autor:
Lili Salinas, Claire B. Montgomery, Francisco Figueroa, Phung N. Thai, Nipavan Chiamvimonvat, Gino Cortopassi, Elena N. Dedkova
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract Friedreich’s ataxia (FA) is an autosomal recessive disorder caused by reduced frataxin (FXN) expression in mitochondria, where the lethal component is cardiomyopathy. Using the conditional Fxn flox/null::MCK-Cre knock-out (Fxn-cKO) mouse m
Externí odkaz:
https://doaj.org/article/307e6813025546cdb878edf29300a76e
Autor:
Maartje Westhoff, Silvia G. del Villar, Taylor L. Voelker, Phung N. Thai, Heather C. Spooner, Alexandre D. Costa, Padmini Sirish, Nipavan Chiamvimonvat, Eamonn J. Dickson, Rose E. Dixon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Cardiac dysfunction is a hallmark of aging in humans and mice. Here we report that a two-week treatment to restore youthful Bridging Integrator 1 (BIN1) levels in the hearts of 24-month-old mice rejuvenates cardiac function and substantially
Externí odkaz:
https://doaj.org/article/b0477fcf8cac487d9b9bce149837c365
Autor:
Jeong Han Lee, Maria C. Perez-Flores, Seojin Park, Hyo Jeong Kim, Yingying Chen, Mincheol Kang, Jennifer Kersigo, Jinsil Choi, Phung N. Thai, Ryan L. Woltz, Dolores Columba Perez-Flores, Guy Perkins, Choong-Ryoul Sihn, Pauline Trinh, Xiao-Dong Zhang, Padmini Sirish, Yao Dong, Wayne Wei Feng, Isaac N. Pessah, Rose E. Dixon, Bernd Sokolowski, Bernd Fritzsch, Nipavan Chiamvimonvat, Ebenezer N. Yamoah
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The inner ear is the hub where hair cells (HCs) transduce sound, gravity, and head acceleration stimuli to the brain. Hearing and balance rely on mechanosensation, the fastest sensory signals transmitted to the brain. The mechanoelectrical t
Externí odkaz:
https://doaj.org/article/2460730132124905aa50c50a2faffa24
Autor:
Maartje Westhoff, Silvia G. del Villar, Taylor L. Voelker, Phung N. Thai, Heather C. Spooner, Alexandre D. Costa, Padmini Sirish, Nipavan Chiamvimonvat, Eamonn J. Dickson, Rose E. Dixon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/c1be2283042645839fbc07427ec467c0
Autor:
Hosna Babini, Verónica Jiménez-Sábado, Ekaterina Stogova, Alia Arslanova, Mariam Butt, Saif Dababneh, Parisa Asghari, Edwin D. W. Moore, Thomas W. Claydon, Nipavan Chiamvimonvat, Leif Hove-Madsen, Glen F. Tibbits
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Atrial fibrillation (AF), the most common arrhythmia, has been associated with different electrophysiological, molecular, and structural alterations in atrial cardiomyocytes. Therefore, more studies are required to elucidate the genetic and molecular
Externí odkaz:
https://doaj.org/article/9fb5fce9358747888e15f06698dd86da
Autor:
Yao-Hui Sun, Hillary K.J. Kao, Phung N. Thai, Regan Smithers, Che-Wei Chang, Dalyir Pretto, Sergey Yechikov, Sarah Oppenheimer, Amanda Bedolla, Brooke A. Chalker, Rana Ghobashy, Jan A. Nolta, James W. Chan, Nipavan Chiamvimonvat, Deborah K. Lieu
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113505- (2023)
Summary: The composite material-like extracellular matrix (ECM) in the sinoatrial node (SAN) supports the native pacemaking cardiomyocytes (PCMs). To test the roles of SAN ECM in the PCM phenotype and function, we engineered reconstructed-SAN heart t
Externí odkaz:
https://doaj.org/article/354257b1ee964620a53ac8fc64610b05
Autor:
Lu Ren, Phung N. Thai, Raghavender Reddy Gopireddy, Valeriy Timofeyev, Hannah A. Ledford, Ryan L. Woltz, Seojin Park, Jose L. Puglisi, Claudia M. Moreno, Luis Fernando Santana, Alana C. Conti, Michael I. Kotlikoff, Yang Kevin Xiang, Vladimir Yarov-Yarovoy, Manuela Zaccolo, Xiao-Dong Zhang, Ebenezer N. Yamoah, Manuel F. Navedo, Nipavan Chiamvimonvat
Publikováno v:
JCI Insight, Vol 7, Iss 22 (2022)
Sinoatrial node (SAN) cells are the heart’s primary pacemaker. Their activity is tightly regulated by β-adrenergic receptor (β-AR) signaling. Adenylyl cyclase (AC) is a key enzyme in the β-AR pathway that catalyzes the production of cAMP. There
Externí odkaz:
https://doaj.org/article/a77e387d0aea4cd39fe56437febaaf3a
Autor:
Yankun Lyu, Valeriy Timofeyev, James Overton, Phung N. Thai, Ebenezer N. Yamoah, Nipavan Chiamvimonvat, Xiao-Dong Zhang
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101301- (2022)
Summary: Intracellular pH (pHi) plays critical roles in the regulation of cardiac function. Methods and techniques for cardiac pHi measurement have continued to evolve since early 1960s. Fluorescent microscopy is the most recently developed technique
Externí odkaz:
https://doaj.org/article/bb83ef9cd538486eb3c234d3e5218493
Autor:
Maria Paz Prada, Arsalan U. Syed, Gopireddy R. Reddy, Miguel Martín-Aragón Baudel, Víctor A. Flores-Tamez, Kent C. Sasse, Sean M. Ward, Padmini Sirish, Nipavan Chiamvimonvat, Peter Bartels, Eamonn J. Dickson, Johannes W. Hell, John D. Scott, Luis F. Santana, Yang K. Xiang, Manuel F. Navedo, Madeline Nieves-Cintrón
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Molecular mechanisms by which glucose modulates L-type Ca2+ channel activity and vascular reactivity are unclear. Here the authors report a nanocomplex orchestrated by AKAP5 that facilitates local purinergic stimulation of L-type Ca2+ channels and va
Externí odkaz:
https://doaj.org/article/16c1bd62635d42608c4af12cd7cb45a7
Autor:
Uma N. Srivatsa, MBBS, MAS, FHRS, Pankaj Malhotra, MD, Xin J. Zhang, MD, Neil Beri, MD, Guibo Xing, PhD, Ann Brunson, PhD, Mohamed Ali, MD, Dali Fan, MD, Nayereh Pezeshkian, MD, MPH, FHRS, Nipavan Chiamvimonvat, MD, Richard H. White, MD
Publikováno v:
Heart Rhythm O2, Vol 1, Iss 2, Pp 96-102 (2020)
Background: Obesity is associated with a higher incidence of atrial fibrillation (AF). Weight reduction improves outcomes in patients known to have AF. Objective: The purpose of this study was to compare the incidence of heart failure (HF) or first-t
Externí odkaz:
https://doaj.org/article/ef36369208b34fa2be5671c4a477c851