Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ninoschka C. D'Souza"'
Autor:
Ninoschka C. D’Souza, Julian A. Aiken, Emily G. Hoffman, Sara C. Atherley, Sabrina Champsi, Nadia Aleali, Dorsa Shakeri, Maya El-Zahed, Nicky Akbarian, Mehran Nejad-Mansouri, Parinaz Z. Bavani, Richard L. Liggins, Owen Chan, Michael C. Riddell
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background: Elevated levels of somatostatin blunt glucagon counterregulation during hypoglycemia in type 1 diabetes (T1D) and this can be improved using somatostatin receptor 2 (SSTR2) antagonists. Hypoglycemia also occurs in late-stage type 2 diabet
Externí odkaz:
https://doaj.org/article/d6004c849ef2466b9d45505754e327f6
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
Glucose homeostasis is primarily maintained by pancreatic hormones, insulin and glucagon, with an emerging role for a third islet hormone, somatostatin, in regulating insulin and glucagon responses. Under healthy conditions, somatostatin secreted fro
Externí odkaz:
https://doaj.org/article/718320647af546e7b81b09a913c81f75
Autor:
Ninoschka C. D’Souza, Durmalouk Kesibi, Christopher Yeung, Dorsa Shakeri, Ashwin I. D’Souza, Alison K. Macpherson, Michael C. Riddell
Publikováno v:
Sensors, Vol 23, Iss 22, p 9059 (2023)
The impact of age, sex and body mass index on interstitial glucose levels as measured via continuous glucose monitoring (CGM) during exercise in the healthy population is largely unexplored. We conducted a multivariable generalized estimating equatio
Externí odkaz:
https://doaj.org/article/b62ef446fd224ba694b31d562aedb373
Autor:
Emily G. Hoffman, Ninoschka C. D'Souza, Julian Aiken, Sara Atherley, Richard Liggins, Michael C. Riddell
Publikováno v:
Diabetes, Obesity and Metabolism. 25:1547-1556
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbd6f5c662081854f345dffaedfcdccc
https://doi.org/10.1111/dom.15002
https://doi.org/10.1111/dom.15002
Autor:
null Emily G. Hoffman, null Ninoschka C. D'Souza, null Julian Aiken, null Sara Atherley, null Richard Liggins, null Michael C. Riddell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7208554a9262f2a32181498d5004be28
https://doi.org/10.1111/dom.15002/v2/response1
https://doi.org/10.1111/dom.15002/v2/response1
Autor:
Rawad Farhat, Julian Aiken, Ninoschka C. D'Souza, Daniel Appadurai, Grayson Hull, Eric Simonson, Richard T. Liggins, Michael C. Riddell, Owen Chan
Publikováno v:
Diabetes, obesitymetabolismREFERENCES. 24(5)
To evaluate the pharmacokinetics and efficacy of a novel somatostatin receptor 2 antagonist, ZT-01, to stimulate glucagon release in rats with type 1 diabetes (T1D).The pharmacokinetics of ZT-01 and PRL-2903 were assessed following intraperitoneal or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22553c402eb17fd95d966fb64cf4990f
https://pubmed.ncbi.nlm.nih.gov/35060297
https://pubmed.ncbi.nlm.nih.gov/35060297
Autor:
Aoibhe M. Pasieka, Richard Liggins, Owen Chan, Mahsa Jahangiriesmaili, Erin R. Mandel, Julian Aiken, Caylee A. Greenberg, Michael C. Riddell, Emily G. Hoffman, Ninoschka C. D’Souza, Trevor Teich
Publikováno v:
Endocrinology
Recent antecedent hypoglycemia is a known source of defective glucose counter-regulation in diabetes; the mechanisms perpetuating the cycle of progressive α-cell failure and recurrent hypoglycemia remain unknown. Somatostatin has been shown to suppr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cc5ac8cf735bbd9a572f9721d5f122d
https://doi.org/10.1210/endocr/bqab189
https://doi.org/10.1210/endocr/bqab189
Autor:
Peter G. Jacobs, Susana R. Patton, Francis J. Doyle, Roy W. Beck, Jennifer L. Sherr, Peter Calhoun, Michael C. Riddell, Durmalouk Kesibi, Robin L. Gal, Mark A. Clements, Ninoschka C. D’Souza, Michael R. Rickels, Corby K. Martin, Christopher Yeung, Zhaomian Li, Jessica R. Castle
Publikováno v:
Diabetes. 70
Background: Using continuous glucose monitoring (CGM), we investigated potential sex-related differences in glycemia during exercise in persons living with type 1 diabetes (T1D) or without diabetes. Methods: Participants used CGM (Dexcom G6), exercis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2876a2815c8ea7c49e752f47ece90bb8
https://doi.org/10.2337/db21-32-lb
https://doi.org/10.2337/db21-32-lb
Publikováno v:
Diabetes. 70
Background: SSTR2a rescues glucagon counterregulation in type 1 diabetic rats. Here, we investigated its potential for resisting hypoglycemic onset in insulin-treated rats with T2D. Methods: T2D was induced in 8-9-week-old, male, Sprague-Dawley rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::439f8de79697be6b1182ae1fbeccc974
https://doi.org/10.2337/db21-133-or
https://doi.org/10.2337/db21-133-or
Autor:
Emily G. Hoffman, Ninoschka C. D’Souza, Michael C. Riddell, Mariya Popkov, Sara C. Atherley, Richard Liggins, Sabrina Champsi
Publikováno v:
Diabetes. 70
Background: Defective glucagon counterregulation to hypoglycemia in T1D involves elevated somatostatin signalling on the α cell. In rats, SSTR2a treatment (ZT-01 Methods: High fat fed, low dose streptozotocin (T2D) and healthy rats were treated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25faa2193791b36810a931ef2c2bfb14
https://doi.org/10.2337/db21-1197-p
https://doi.org/10.2337/db21-1197-p