O-GlcNAcylation controls pro-fibrotic transcriptional regulatory signaling in myofibroblasts

Autor: Ninon Very, Clémence Boulet, Céline Gheeraert, Alexandre Berthier, Manuel Johanns, Mohamed Bou Saleh, Loïc Guille, Fabrice Bray, Jean-Marc Strub, Marie Bobowski-Gerard, Francesco P. Zummo, Emmanuelle Vallez, Olivier Molendi-Coste, Eloise Woitrain, Sarah Cianférani, David Montaigne, Line Carolle Ntandja-Wandji, Laurent Dubuquoy, Julie Dubois-Chevalier, Bart Staels, Philippe Lefebvre, Jérôme Eeckhoute

Publikováno v: Cell Death and Disease, Vol 15, Iss 6, Pp 1-22 (2024)

Abstract Tissue injury causes activation of mesenchymal lineage cells into wound-repairing myofibroblasts (MFs), whose uncontrolled activity ultimately leads to fibrosis. Although this process is triggered by deep metabolic and transcriptional reprog

Externí odkaz: https://doaj.org/article/7c469a228cd14e0cb8f4aa98dabc701e

Targeting O-GlcNAcylation to overcome resistance to anti-cancer therapies

Autor: Ninon Very, Ikram El Yazidi-Belkoura

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

In cancer cells, metabolic reprogramming is associated with an alteration of the O-GlcNAcylation homeostasis. This post-translational modification (PTM) that attaches O-GlcNAc moiety to intracellular proteins is dynamically and finely regulated by th

Externí odkaz: https://doaj.org/article/9797206a006c40609e7b045ee22ca267

Dual regulation of fatty acid synthase (FASN) expression by O-GlcNAc transferase (OGT) and mTOR pathway in proliferating liver cancer cells

Autor: Alexis Gadault, Anne-Sophie Vercoutter-Edouart, Ninon Very, Amélie Decourcelle, Tony Lefebvre, Ganna Panasyuk, Ikram El Yazidi-Belkoura, Stéphan Hardivillé, Céline Schulz, Marlène Mortuaire, Quentin Lemaire, Sadia Raab, Steffi Baldini, Vanessa Dehennaut

Publikováno v: Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, Springer Verlag, 2021, Cellular and Molecular Life Sciences, 78 (10), ⟨10.1007/s00018-021-03857-z⟩
Cellular and Molecular Life Sciences, 2021, Cellular and Molecular Life Sciences, 78 (10), ⟨10.1007/s00018-021-03857-z⟩

International audience; Fatty acid synthase (FASN) participates in many fundamental biological processes, including energy storage and signal transduction, and is overexpressed in many cancer cells. We previously showed in a context of lipogenesis th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2046a0425144f2036c092541a8e856ea
https://doi.org/10.1007/s00018-021-03857-z

Evaluation of the expression of fatty acid synthase and O‑GlcNAc transferase in patients with liver cancer by exploration of transcriptome databases and experimental approaches

Autor: Sadia Raab, Ninon Very, Belinda Duchêne, Pierre Rybarczyk, Nicolas Jonckheere, Ikram El Yazidi‑belkoura, Tony Lefebvre

Publikováno v: Oncology Letters
Oncology Letters, 2022, 23 (4), pp.105. ⟨10.3892/ol.2022.13225⟩

International audience; Tumor occurrence and development are closely related to metabolism abnormalities. One of the metabolic networks that is dysregulated during carcinogenesis is the fatty acid synthesis pathway, which is mainly controlled by fatt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14321294d63bfea1c667090e57a68d97
https://doi.org/10.3892/ol.2022.13225

Evaluation of the expression of fatty acid synthase and

Autor: Sadia, Raab, Ninon, Very, Belinda, Duchêne, Pierre, Rybarczyk, Nicolas, Jonckheere, Ikram, El Yazidi-Belkoura, Tony, Lefebvre

Publikováno v: Oncology letters. 23(4)

Tumor occurrence and development are closely related to metabolism abnormalities. One of the metabolic networks that is dysregulated during carcinogenesis is the fatty acid synthesis pathway, which is mainly controlled by fatty acid synthase (FASN).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d432585fff05658edb175936307948fd
https://pubmed.ncbi.nlm.nih.gov/35242233