Bacterially derived synthetic mimetics of mammalian oligomannose prime antibody responses that neutralize HIV infectivity

Autor: Ralph Pantophlet, Nino Trattnig, Sasha Murrell, Naiomi Lu, Dennis Chau, Caitlin Rempel, Ian A. Wilson, Paul Kosma

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)

Neutralizing antibodies to oligomannose glycans on HIV Env are difficult to elicit, possibly due to B cell tolerance. Here, Pantophlet et al. synthesize mimetics based on a bacterial oligosaccharide and show that they evoke HIV-neutralizing antibody

Externí odkaz: https://doaj.org/article/6f723175653248f8b81328e5c6e0e922

Site-Specific Multi-Functionalization of the Carrier Protein CRM

Autor: Nino, Trattnig, Zeshi, Li, Gerlof P, Bosman, Paul, Kosma, Geert-Jan, Boons

Publikováno v: Chembiochem : a European journal of chemical biology. 23(21)

Conjugation of an antigen to a carrier protein is widely used for vaccine development. To develop the next generation of conjugate vaccines, we describe here a method for the controlled multi-functionalization of the widely employed carrier protein C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::188eee0f219a448b10bbef8c90297a38
https://pubmed.ncbi.nlm.nih.gov/36098623

Rhamnogalacturonan II: Chemical Synthesis of a Substructure Including α‐2,3‐Linked Kdo**

Autor: Cecilia Romanò, Enzo Mancuso, Philipp J. Gritsch, Mads Hartvig Clausen, Nino Trattnig, Paul Kosma

Publikováno v: Mancuso, E, Romanò, C, Trattnig, N, Gritsch, P, Kosma, P & Clausen, M H 2021, ' Rhamnogalacturonan II-Chemical Synthesis of a Substructure Including α-2,3-Linked Kdo ', Chemistry-A European Journal, vol. 27, no. 24, pp. 7099-7102 . https://doi.org/10.1002/chem.202100837

The synthesis of a fully deprotected Kdo-containing rhamnogalacturonan II pentasaccharide is described. The strategy relies on the preparation of a suitably protected homogalacturonan tetrasaccharide backbone through a post-glycosylation oxidation ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1fd0bcbf00bf079fd2216971731548
https://doi.org/10.1002/chem.202100837

HIV-1 Entry and Prospects for Protecting against Infection

Autor: Nino Trattnig, Jean-François Bruxelle, Marianne W. Mureithi, Elise Landais, Ralph Pantophlet

Publikováno v: Microorganisms
Microorganisms, Vol 9, Iss 228, p 228 (2021)

Human Immunodeficiency Virus type-1 (HIV-1) establishes a latent viral reservoir soon after infection, which poses a major challenge for drug treatment and curative strategies. Many efforts are therefore focused on blocking infection. To this end, bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0498e1499773b4c465443143997a6a78
https://pubmed.ncbi.nlm.nih.gov/33499233

Bacterially derived synthetic mimetics of mammalian oligomannose prime antibody responses that neutralize HIV infectivity

Autor: Ian A. Wilson, Dennis Chau, Ralph Pantophlet, Caitlin Rempel, Sasha Murrell, Paul Kosma, Nino Trattnig, Naiomi Lu

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications

Oligomannose-type glycans are among the major targets on the gp120 component of the HIV envelope protein (Env) for broadly neutralizing antibodies (bnAbs). However, attempts to elicit oligomannose-specific nAbs by immunizing with natural or synthetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97648c36546d4fd8c1c896534c75785
https://doi.org/10.1038/s41467-017-01640-y