Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ninning Liu"'
Publikováno v:
eLife, Vol 7 (2018)
Multi-subunit ring-shaped ATPases are molecular motors that harness chemical free energy to perform vital mechanical tasks such as polypeptide translocation, DNA unwinding, and chromosome segregation. Previously we reported the intersubunit coordinat
Externí odkaz:
https://doaj.org/article/b4fae2f52ae041cf82385a92329e7341
Publikováno v:
eLife, Vol 4 (2015)
SpoIIIE is a homo-hexameric dsDNA translocase responsible for completing chromosome segregation in Bacillus subtilis. Here, we use a single-molecule approach to monitor SpoIIIE translocation when challenged with neutral-backbone DNA and non-hydrolyza
Externí odkaz:
https://doaj.org/article/83d6c5720b684f75b2d18d4b2d78fc88
Autor:
Jocelyn Y. Kishi, Ninning Liu, Emma R. West, Kuanwei Sheng, Jack J. Jordanides, Matthew Serrata, Constance L. Cepko, Sinem K. Saka, Peng Yin
Publikováno v:
Nature Methods. 19:1393-1402
We present Light-Seq, an approach for multiplexed spatial indexing of intact biological samples using light-directed DNA barcoding in fixed cells and tissues followed by ex situ sequencing. Light-Seq combines spatially targeted, rapid photocrosslinki
Autor:
Inga-Marie Schaefer, Matthew L. Hemming, Meijun Z. Lundberg, Matthew P. Serrata, Isabel Goldaracena, Ninning Liu, Peng Yin, Joao A. Paulo, Steven P. Gygi, Suzanne George, Jeffrey A. Morgan, Monica M. Bertagnolli, Ewa T. Sicinska, Chen Chu, Shanshan Zheng, Adrian Mariño-Enríquez, Jason L. Hornick, Chandrajit P. Raut, Wen-Bin Ou, George D. Demetri, Sinem K. Saka, Jonathan A. Fletcher
Publikováno v:
British Journal of Cancer. 127:2072-2085
Advanced gastrointestinal stromal tumour (GIST) is characterised by genomic perturbations of key cell cycle regulators. Oncogenic activation of CDK4/6 results in RB1 inactivation and cell cycle progression. Given that single-agent CDK4/6 inhibitor th
Autor:
Ninning Liu
We present Light-Seq, an approach for multiplexed spatial indexing of intact biological samples using light-directed DNA barcoding infixed cells and tissues followed by ex situ sequencing. Light-Seq combines spatially targeted, rapid photocrosslinkin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c536790a699f28bcf742fb75706fd7c9
https://doi.org/10.17504/protocols.io.eq2ly77jplx9/v3
https://doi.org/10.17504/protocols.io.eq2ly77jplx9/v3
Autor:
Inga-Marie Schaefer, Matthew L. Hemming, Meijun Z. Lundberg, Matthew P. Serrata, Isabel Goldaracena, Ninning Liu, Peng Yin, Joao A. Paulo, Steven P. Gygi, Suzanne George, Jeffrey A. Morgan, Monica M. Bertagnolli, Ewa T. Sicinska, Adrian Mariño-Enríquez, Jason L. Hornick, Chandrajit P. Raut, George D. Demetri, Wen-Bin Ou, Sinem K. Saka, Jonathan A. Fletcher
Publikováno v:
Clinical Cancer Research. 28:A013-A013
Advanced GIST is characterized by genomic perturbations of key cell cycle regulators. Oncogenic activation of CDK4/6 results in RB1 inactivation and cell cycle progression. Given that single-agent CDK4/6 inhibitor (CDK4/6i) therapy failed to show cli
Autor:
Inga-Marie Schaefer, Meijun Z. Lundberg, Matthew L. Hemming, Sinem K. Saka, Matthew P. Serrata, Isabel Goldaracena, Ninning Liu, Peng Yin, Joao A. Paulo, Steven Gygi, George D. Demetri, Ewa Sicinska, Adrian Mariño-Enríquez, Jason L. Hornick, Chandrajit P. Raut, Wen-Bin Ou, Jonathan A. Fletcher
Publikováno v:
Cancer Research. 82:5648-5648
Gastrointestinal stromal tumor (GIST) is the most common GI sarcoma and is generally initiated by KIT or PDGFRA mutations which are compelling therapeutic targets for tyrosine kinase inhibitors (TKI). However, the emergence of secondary mutations res
Publikováno v:
Biophysical Journal. 118:146a
Publikováno v:
Nature chemistry
Recent advances in localisation-based super-resolution microscopy have enabled researchers to visualise single molecular features down to individual molecular components (~5 nm), but do not yet allow manipulation of single-molecule targets in a user-
Publikováno v:
Liu, N; Chistol, G; Cui, Y; & Bustamante, C. (2018). Mechanochemical coupling and bi-phasic force-velocity dependence in the ultra-fast ring ATPase SpoIIIE.. eLife, 7. doi: 10.7554/eLife.32354. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/0x57g70t
eLife, Vol 7 (2018)
eLife
eLife, Vol 7 (2018)
eLife
Multi-subunit ring-shaped ATPases are molecular motors that harness chemical free energy to perform vital mechanical tasks such as polypeptide translocation, DNA unwinding, and chromosome segregation. Previously we reported the intersubunit coordinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c872d98a7801858c3348a32ee480ca2
http://www.escholarship.org/uc/item/0x57g70t
http://www.escholarship.org/uc/item/0x57g70t