DNA methylation and gene expression of TXNIP in adult offspring of women with diabetes in pregnancy.

Autor: Azadeh Houshmand-Oeregaard, Line Hjort, Louise Kelstrup, Ninna S Hansen, Christa Broholm, Linn Gillberg, Tine D Clausen, Elisabeth R Mathiesen, Peter Damm, Allan Vaag

Publikováno v: PLoS ONE, Vol 12, Iss 10, p e0187038 (2017)

Fetal exposure to maternal diabetes increases the risk of type 2 diabetes (T2DM), possibly mediated by epigenetic mechanisms. Low blood TXNIP DNA methylation has been associated with elevated glucose levels and risk of T2DM, and increased skeletal mu

Externí odkaz: https://doaj.org/article/3b0ab48dd793492296252cd892c80fc8

Dysregulation of a novel miR-23b/27b-p53 axis impairs muscle stem cell differentiation of humans with type 2 diabetes

Autor: Tora I. Henriksen, Peter K. Davidsen, Maria Pedersen, Heidi S. Schultz, Ninna S. Hansen, Therese J. Larsen, Allan Vaag, Bente K. Pedersen, Søren Nielsen, Camilla Scheele

Publikováno v: Molecular Metabolism, Vol 6, Iss 7, Pp 770-779 (2017)

Objective: MicroRNAs (miRNAs) are increasingly recognized as fine-tuning regulators of metabolism, and are dysregulated in several disease conditions. With their capacity to rapidly change gene expression, miRNAs are also important regulators of deve

Externí odkaz: https://doaj.org/article/8a6a4be7c9c544ba887e874ac2febe50

Heterogeneity in the perirenal region of humans suggests presence of dormant brown adipose tissue that contains brown fat precursor cells

Autor: Bo Feldt-Rasmussen, Amir Feizi, Helle B. Hattel, Ninna S. Hansen, Rikke Krogh-Madsen, Naja Z. Jespersen, Sarah E Heywood, Camilla Scheele, Søren Nielsen, Per Bagi, Natasa Petrovic, Bente Klarlund Pedersen, Lone Peijs, Eline S. Andersen, Søren Daugaard, Heidi S. Schultz

Publikováno v: Molecular Metabolism
Molecular Metabolism, Vol 24, Iss, Pp 30-43 (2019)
Jespersen, N Z, Feizi, A, Andersen, E S, Heywood, S, Hattel, H B, Daugaard, S, Peijs, L, Bagi, P, Feldt-Rasmussen, B, Schultz, H S, Hansen, N S, Krogh-Madsen, R, Pedersen, B K, Petrovic, N, Nielsen, S & Scheele, C 2019, ' Heterogeneity in the perirenal region of humans suggests presence of dormant brown adipose tissue that contains brown fat precursor cells ', Molecular Metabolism, vol. 24, pp. 30-43 . https://doi.org/10.1016/j.molmet.2019.03.005

Objective Increasing the amounts of functionally competent brown adipose tissue (BAT) in adult humans has the potential to restore dysfunctional metabolism and counteract obesity. In this study, we aimed to characterize the human perirenal fat depot,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca0c8b6e1578979b0f70f3d782b230df
https://doi.org/10.1016/j.molmet.2019.03.005

Increased expression of microRNA-15a and microRNA-15b in skeletal muscle from adult offspring of women with diabetes in pregnancy

Autor: Maren Schrölkamp, Louise Kelstrup, Tine D. Clausen, Azadeh Houshmand-Oeregaard, Peter Damm, Christa Broholm, Allan Vaag, Elisabeth R. Mathiesen, Ninna S. Hansen, Line Hjort, Anne Cathrine B. Thuesen

Publikováno v: Human Molecular Genetics. 27:1763-1771

Offspring of women with diabetes in pregnancy exhibit skeletal muscle insulin resistance and are at increased risk of developing type 2 diabetes, potentially mediated by epigenetic mechanisms or changes in the expression of small non-coding microRNAs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a7f16b7a0e469b5f76cb9298e8dab9
https://doi.org/10.1093/hmg/ddy085

Epigenetic programming of adipose-derived stem cells in low birthweight individuals

Autor: Ninna S. Hansen, Alexander Perfilyev, Camilla Scheele, Rasmus Ribel-Madsen, Klaudia Stanislawa Strasko, Maren Schrölkamp, Allan Vaag, Sine W. Jørgensen, Anders H. Olsson, Brynjulf Mortensen, Charlotte Ling, Christa Broholm

Publikováno v: Diabetologia. 59:2664-2673

Low birthweight (LBW) is associated with dysfunctions of adipose tissue and metabolic disease in adult life. We hypothesised that altered epigenetic and transcriptional regulation of adipose-derived stem cells (ADSCs) could play a role in programming

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2863a4217c8172c17c7a7bff454b8a9e
https://doi.org/10.1007/s00125-016-4099-9