Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ninna C. S. Voss"'
Autor:
Ninna C. S. Voss, Thomas Dreyer, Mikkel B. Henningsen, Pernille Vahl, Bent Honoré, Ebbe Boedtkjer
Publikováno v:
Cancers, Vol 12, Iss 4, p 891 (2020)
The acidic tumor microenvironment modifies malignant cell behavior. Here, we study consequences of the microenvironment in breast carcinomas. Beginning at carcinogen-based breast cancer induction, we supply either regular or NaHCO3-containing drinkin
Externí odkaz:
https://doaj.org/article/b609ea6c849a44b9b027b0284705d247
Autor:
Rasmus A. Sloth, Trine V. Axelsen, Maria Sofia Espejo, Nicolai J. Toft, Ninna C. S. Voss, Mark Burton, Mads Thomassen, Pernille Vahl, Ebbe Boedtkjer
Publikováno v:
Sloth, R A, Axelsen, T V, Espejo, M S, Toft, N J, Voss, N C S, Burton, M, Thomassen, M, Vahl, P & Boedtkjer, E 2022, ' Loss of RPTPγ primes breast tissue for acid extrusion, promotes malignant transformation and results in early tumour recurrence and shortened survival ', British Journal of Cancer, vol. 127, no. 7, pp. 1226-1238 . https://doi.org/10.1038/s41416-022-01911-6
Background: While cellular metabolism and acidic waste handling accelerate during breast carcinogenesis, temporal patterns of acid–base regulation and underlying molecular mechanisms responding to the tumour microenvironment remain unclear. Methods
Autor:
Mikkel B. Henningsen, Kezia McWhan, Vibeke S. Dam, Marco Mele, Katrine R. Hauerslev, Ninna C. S. Voss, Parag D. Dabir, Eva Balling, Helene L. Pedersen, Pernille Vahl, Tonje Johansen, Trine Tramm, Peer M. Christiansen, Ebbe Boedtkjer
Publikováno v:
Henningsen, M B, McWhan, K, Dam, V S, Mele, M, Hauerslev, K R, Voss, N C S, Dabir, P D, Balling, E, Pedersen, H L, Vahl, P, Johansen, T, Tramm, T, Christiansen, P M & Boedtkjer, E 2022, ' Amplified Ca 2+ dynamics and accelerated cell proliferation in breast cancer tissue during purinergic stimulation ', International Journal of Cancer, vol. 151, no. 7, pp. 1150-1165 . https://doi.org/10.1002/ijc.34147
Intracellular Ca 2+ dynamics shape malignant behaviors of cancer cells. Whereas previous studies focused on cultured cancer cells, we here used breast organoids and colonic crypts freshly isolated from human and murine surgical biopsies. We performed
Autor:
Mikkel B, Henningsen, Kezia, McWhan, Vibeke S, Dam, Marco, Mele, Katrine R, Hauerslev, Ninna C S, Voss, Parag D, Dabir, Eva, Balling, Helene L, Pedersen, Pernille, Vahl, Tonje, Johansen, Trine, Tramm, Peer M, Christiansen, Ebbe, Boedtkjer
Publikováno v:
International journal of cancer. 151(7)
Intracellular Ca
Autor:
Ebbe Boedtkjer, Ninna C. S. Voss, Bent Honoré, Pernille Vahl, Thomas Dreyer, Mikkel B. Henningsen
Publikováno v:
Cancers, Vol 12, Iss 891, p 891 (2020)
Voss, N C S, Dreyer, T K, Henningsen, M B, Vahl, P, Honoré, B & Boedtkjer, E 2020, ' Targeting the acidic tumor microenvironment: Unexpected pro-neoplastic effects of oral NaHCO3 therapy in murine breast tissue ', Cancers, vol. 12, no. 4, 891 . https://doi.org/10.3390/cancers12040891
Cancers
Volume 12
Issue 4
Voss, N C S, Dreyer, T K, Henningsen, M B, Vahl, P, Honoré, B & Boedtkjer, E 2020, ' Targeting the acidic tumor microenvironment: Unexpected pro-neoplastic effects of oral NaHCO3 therapy in murine breast tissue ', Cancers, vol. 12, no. 4, 891 . https://doi.org/10.3390/cancers12040891
Cancers
Volume 12
Issue 4
The acidic tumor microenvironment modifies malignant cell behavior. Here, we study consequences of the microenvironment in breast carcinomas. Beginning at carcinogen-based breast cancer induction, we supply either regular or NaHCO3-containing drinkin
Publikováno v:
Voss, N C S, Kold-Petersen, H H & Boedtkjer, E 2019, ' Enhanced nitric oxide signaling amplifies vasorelaxation of human colon cancer feed arteries ', American Journal of Physiology: Heart and Circulatory Physiology, vol. 316, no. 1, pp. H245-H254 . https://doi.org/10.1152/ajpheart.00368.2018
Inadequate perfusion of solid cancer tissue results in low local nutrient and oxygen levels and accumulation of acidic waste products. Previous investigations have focused primarily on tumor blood vessel architecture, and we lack information concerni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4665622b514fc6642a40631c6b60c6f8
https://pure.au.dk/portal/da/publications/enhanced-nitric-oxide-signaling-amplifies-vasorelaxation-of-human-colon-cancer-feed-arteries(fce94c12-b044-4f3a-8a43-2c60600d6199).html
https://pure.au.dk/portal/da/publications/enhanced-nitric-oxide-signaling-amplifies-vasorelaxation-of-human-colon-cancer-feed-arteries(fce94c12-b044-4f3a-8a43-2c60600d6199).html
Autor:
Henrik Kold-Petersen, Ninna C. S. Voss, Casper Homilius, Ebbe Boedtkjer, Mikkel B. Henningsen
Publikováno v:
Voss, N C S, Kold-Petersen, H H, Henningsen, M B, Homilius, C & Boedtkjer, E 2019, ' Upregulated Na + /H +-exchange protects human colon cancer tissue against intracellular acidification ', BioMed Research International, vol. 2019, 3702783 . https://doi.org/10.1155/2019/3702783
BioMed Research International
BioMed Research International, Vol 2019 (2019)
BioMed Research International
BioMed Research International, Vol 2019 (2019)
Increased metabolism accelerates local acid production in cancer tissue. The mechanisms eliminating acidic waste products from human colon cancer tissue represent promising therapeutic targets for pharmacological manipulation in order to improve prog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::100bf714c00d6aa3a98379d7784224cf
https://pure.au.dk/portal/da/publications/upregulated-nahexchange-protects-human-colon-cancer-tissue-against-intracellular-acidification(08df03a6-f0bc-4f85-9e91-5d4daf27a06f).html
https://pure.au.dk/portal/da/publications/upregulated-nahexchange-protects-human-colon-cancer-tissue-against-intracellular-acidification(08df03a6-f0bc-4f85-9e91-5d4daf27a06f).html