Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Ninib, Baryawno"'
Autor:
Thale K. Olsen, Jörg Otte, Shenglin Mei, Bethel Tesfai Embaie, Polina Kameneva, Huaitao Cheng, Teng Gao, Vasilios Zachariadis, Ioanna Tsea, Åsa Björklund, Emil Kryukov, Ziyi Hou, Anna Johansson, Erik Sundström, Tommy Martinsson, Susanne Fransson, Jakob Stenman, Shahrzad Shirazi Fard, John Inge Johnsen, Per Kogner, Igor Adameyko, Martin Enge, Peter V. Kharchenko, Ninib Baryawno
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-12 (2024)
Abstract Background Neuroblastoma (NB) is a heterogeneous embryonal malignancy and the deadliest tumor of infancy. It is a complex disease that can result in diverse clinical outcomes. In some children, tumors regress spontaneously. Others respond we
Externí odkaz:
https://doaj.org/article/1d5da37f62bb4e9c8494a94bf33d81b4
Autor:
Shenglin Mei, Adele M. Alchahin, Ioanna Tsea, Youmna Kfoury, Taghreed Hirz, Nathan Elias Jeffries, Ting Zhao, Yanxin Xu, Hanyu Zhang, Hirak Sarkar, Shulin Wu, Alexander O. Subtelny, John Inge Johnsen, Yida Zhang, Keyan Salari, Chin-Lee Wu, Mark A. Randolph, David T. Scadden, Douglas M. Dahl, John Shin, Peter V. Kharchenko, Philip J. Saylor, David B. Sykes, Ninib Baryawno
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-21 (2024)
Abstract Background Despite therapeutic advances, once a cancer has metastasized to the bone, it represents a highly morbid and lethal disease. One third of patients with advanced clear cell renal cell carcinoma (ccRCC) present with bone metastasis a
Externí odkaz:
https://doaj.org/article/f630748728fb49e9b520cfa367f96514
Autor:
Nakyung Kang, Jaesung Kim, Munju Kwon, Yonghae Son, Seong-Kug Eo, Ninib Baryawno, Byoung Soo Kim, Sik Yoon, Sae-Ock Oh, Dongjun Lee, Koanhoi Kim
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10381 (2024)
Atherosclerosis is characterized by the deposition and accumulation of extracellular cholesterol and inflammatory cells in the arterial blood vessel walls, and 27-hydroxycholesterol (27OHChol) is the most abundant cholesterol metabolite. 27OHChol is
Externí odkaz:
https://doaj.org/article/92b424dd17c44b5fb1534fa4df0339ea
Autor:
Soo-Yeon Woo, Wan-Seog Shim, Hyejin Lee, Ninib Baryawno, Parkyong Song, Byoung Soo Kim, Sik Yoon, Sae-Ock Oh, Dongjun Lee
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10517 (2024)
Hematopoietic stem cells (HSCs) reside in specific microenvironments that facilitate their regulation through both internal mechanisms and external cues. Bone marrow endothelial cells (BMECs), which are found in one of these microenvironments, play a
Externí odkaz:
https://doaj.org/article/9856f7e9e3ad474b8be194bcd35ea073
Autor:
Anders Valind, Bronte Manouk Verhoeven, Jens Enoksson, Jenny Karlsson, Gustav Christensson, Adriana Mañas, Kristina Aaltonen, Caroline Jansson, Daniel Bexell, Ninib Baryawno, David Gisselsson, Catharina Hagerling
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTDespite aggressive treatment, the 5-year event-free survival rate for children with high-risk neuroblastoma is
Externí odkaz:
https://doaj.org/article/b026693053e149a8a14c87e0554ab387
Autor:
Taghreed Hirz, Shenglin Mei, Hirak Sarkar, Youmna Kfoury, Shulin Wu, Bronte M. Verhoeven, Alexander O. Subtelny, Dimitar V. Zlatev, Matthew W. Wszolek, Keyan Salari, Evan Murray, Fei Chen, Evan Z. Macosko, Chin-Lee Wu, David T. Scadden, Douglas M. Dahl, Ninib Baryawno, Philip J. Saylor, Peter V. Kharchenko, David B. Sykes
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
The immune suppressive tumour microenvironment drives recurrence and metastatic disease in prostate cancer. Here authors provide a detailed analysis of the microenvironment via single cell RNA sequencing and high-resolution spatial transcriptomics to
Externí odkaz:
https://doaj.org/article/3cd0eef88431429c83f9fdcbfc80a90b
Autor:
Soo-Yeon Woo, Hansong Lee, Su Min Park, Hee-Seon Choi, Jayoung Kim, Munju Kwon, Jihyung Sohn, Ji Ho Nam, Hyung-Sik Kim, Parkyong Song, Ninib Baryawno, Yun-Hak Kim, Koanhoi Kim, Dongjun Lee
Publikováno v:
Cell Death and Disease, Vol 13, Iss 10, Pp 1-11 (2022)
Abstract Oxysterols are oxygenated derivatives of cholesterol that contain an additional hydroxy, epoxide, or ketone group in the sterol nucleus and/or a hydroxyl group in the side chain of the cholesterol molecule. 27-Hydroxycholesterol (27HC) is a
Externí odkaz:
https://doaj.org/article/30aaa685c02e4e1486a148447b3e787a
Autor:
Adele M. Alchahin, Shenglin Mei, Ioanna Tsea, Taghreed Hirz, Youmna Kfoury, Douglas Dahl, Chin-Lee Wu, Alexander O. Subtelny, Shulin Wu, David T. Scadden, John H. Shin, Philip J. Saylor, David B. Sykes, Peter V. Kharchenko, Ninib Baryawno
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Metastatic clear cell renal cell carcinoma has a poor prognosis. Here, the authors use single cell RNA-seq to show a distinct gene expression signature in the primary tumour of metastatic patients, and highlights immune cell receptor interactions as
Externí odkaz:
https://doaj.org/article/a11f74aa662a481ab379cd4d82caf546
Autor:
Ahyoung Jo, Jae-Hwan Kwak, Soo-Yeon Woo, Bo-Young Kim, Yonghae Son, Hee-Seon Choi, Jayoung Kim, Munju Kwon, Hyok-Rae Cho, Seong-Kug Eo, Ji Ho Nam, Hyung-Sik Kim, Ninib Baryawno, Dongjun Lee, Koanhoi Kim
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Several derivatives derived from the oxime structure have been reported as potential anticancer agents in various cancers. Here, we first tested a novel oxime-containing derivative of 2-((2,4,5-trifluorobenzyl)oxy)benzaldehyde oxime (TFOBO)
Externí odkaz:
https://doaj.org/article/1e452fcf232c4348a1c81f6e13967c4c
Autor:
Thale Kristin Olsen, Cecilia Dyberg, Bethel Tesfai Embaie, Adele Alchahin, Jelena Milosevic, Jane Ding, Jörg Otte, Conny Tümmler, Ida Hed Myrberg, Ellen M. Westerhout, Jan Koster, Rogier Versteeg, Han-Fei Ding, Per Kogner, John Inge Johnsen, David B. Sykes, Ninib Baryawno
Publikováno v:
JCI Insight, Vol 7, Iss 17 (2022)
Despite intensive therapy, children with high-risk neuroblastoma are at risk of treatment failure. We applied a multiomic system approach to evaluate metabolic vulnerabilities in human neuroblastoma. We combined metabolomics, CRISPR screening, and tr
Externí odkaz:
https://doaj.org/article/2b75513611ff4f3b9d9eca1d88064b72