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Akademický článek

Extracellular signal regulated kinase 5 promotes cell migration, invasion and lung metastasis in a FAK-dependent manner

Autor: Weiwei Jiang, Fangfang Cai, Huangru Xu, Yanyan Lu, Jia Chen, Jia Liu, Nini Cao, Xiangyu Zhang, Xiao Chen, Qilai Huang, Hongqin Zhuang, Zi-Chun Hua

Publikováno v: Protein & Cell, Vol 11, Iss 11, Pp 825-845 (2020)

Abstract This study was designed to evaluate ERK5 expression in lung cancer and malignant melanoma progression and to ascertain the involvement of ERK5 signaling in lung cancer and melanoma. We show that ERK5 expression is abundant in human lung canc

Externí odkaz: https://doaj.org/article/3e69c57233544858b4d56cb945b08e0a

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Akademický článek

Extracellular signal-regulated kinase 5 increases radioresistance of lung cancer cells by enhancing the DNA damage response

Autor: Weiwei Jiang, Guanghui Jin, Fangfang Cai, Xiao Chen, Nini Cao, Xiangyu Zhang, Jia Liu, Fei Chen, Feng Wang, Wei Dong, Hongqin Zhuang, Zi-Chun Hua

Publikováno v: Experimental and Molecular Medicine, Vol 51, Iss 2, Pp 1-20 (2019)

Abstract Radiotherapy is a frequent mode of cancer treatment, although the development of radioresistance limits its effectiveness. Extensive investigations indicate the diversity of the mechanisms underlying radioresistance. Here, we aimed to explor

Externí odkaz: https://doaj.org/article/dd1e00550cd9432085c54175cac9e99e

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Akademický článek

Aspirin potentiates celecoxib-induced growth inhibition and apoptosis in human non-small cell lung cancer by targeting GRP78 activity

Autor: Xiangyu Zhang, Jia Chen, Cheng Cheng, Ping Li, Fangfang Cai, Huangru Xu, Yanyan Lu, Nini Cao, Jia Liu, Jigang Wang, Zi-Chun Hua, Hongqin Zhuang

Publikováno v: Therapeutic Advances in Medical Oncology, Vol 12 (2020)

Background: Aspirin has recently emerged as an anticancer drug, but its therapeutic effect on lung cancer has been rarely reported, and the mechanism of action is still unclear. Long-term use of celecoxib in large doses causes serious side effects, a

Externí odkaz: https://doaj.org/article/9b44278ffb4645408ff7daa133e75f00

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Akademický článek

Metformin Synergistically Enhanced the Antitumor Activity of Celecoxib in Human Non-Small Cell Lung Cancer Cells

Autor: Nini Cao, Yanyan Lu, Jia Liu, Fangfang Cai, Huangru Xu, Jia Chen, Xiangyu Zhang, Zi-Chun Hua, Hongqin Zhuang

Publikováno v: Frontiers in Pharmacology, Vol 11 (2020)

Celecoxib has potential as an effective antineoplastic agent, but it may exhibit side effects. Given the glucose-addicted properties of tumor cells, metformin is recognized for its inhibitory effect on oxidative phosphorylation. In the present study,

Externí odkaz: https://doaj.org/article/b8f040ce4e8b492aa34efae824fe0cbe

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Extracellular signal regulated kinase 5 promotes cell migration, invasion and lung metastasis in a FAK-dependent manner

Autor: Huangru Xu, Zi-Chun Hua, Xiao Chen, Hongqin Zhuang, Nini Cao, Jia Liu, Xiangyu Zhang, Weiwei Jiang, Yanyan Lu, Qilai Huang, Jia Chen, Fangfang Cai

Publikováno v: Protein & Cell, Vol 11, Iss 11, Pp 825-845 (2020)
Protein & Cell

This study was designed to evaluate ERK5 expression in lung cancer and malignant melanoma progression and to ascertain the involvement of ERK5 signaling in lung cancer and melanoma. We show that ERK5 expression is abundant in human lung cancer sample

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e658d994bdd5c36184480156f3c3cf50
https://doaj.org/article/3e69c57233544858b4d56cb945b08e0a

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Extracellular signal-regulated kinase 5 increases radioresistance of lung cancer cells by enhancing the DNA damage response

Autor: Fei Chen, Hongqin Zhuang, Feng Wang, Weiwei Jiang, Fangfang Cai, Wei Dong, Nini Cao, Xiao Chen, Guang-Hui Jin, Jia Liu, Zi-Chun Hua, Xiangyu Zhang

Publikováno v: Experimental and Molecular Medicine, Vol 51, Iss 2, Pp 1-20 (2019)
Experimental & Molecular Medicine

Radiotherapy is a frequent mode of cancer treatment, although the development of radioresistance limits its effectiveness. Extensive investigations indicate the diversity of the mechanisms underlying radioresistance. Here, we aimed to explore the eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2e2c0fcf87e7f810b7331ce8e27aacb
https://doi.org/10.1038/s12276-019-0209-3

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Aspirin potentiates celecoxib-induced growth inhibition and apoptosis in human non-small cell lung cancer by targeting GRP78 activity

Autor: Huangru Xu, Xiangyu Zhang, Hongqin Zhuang, Yanyan Lu, Nini Cao, Jigang Wang, Ping Li, Zi-Chun Hua, Cheng Cheng, Fangfang Cai, Jia Chen, Jia Liu

Publikováno v: Therapeutic Advances in Medical Oncology, Vol 12 (2020)
Therapeutic Advances in Medical Oncology
Therapeutic advances in medical oncology, 12. SAGE Publications Inc.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f72e60030c6ba2cbd8dc89a6508e0b8
https://doaj.org/article/9b44278ffb4645408ff7daa133e75f00

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ADT-OH, a hydrogen sulfide-releasing donor, induces apoptosis and inhibits the development of melanoma in vivo by upregulating FADD

Autor: Huangru Xu, Jian Cheng, Xiangyu Zhang, Zi-Chun Hua, Nini Cao, Yanyan Lu, Jia Liu, Jia Chen, Fangfang Cai, Yunwen Yang, Hongqin Zhuang

Publikováno v: Cell Death and Disease, Vol 11, Iss 1, Pp 1-15 (2020)
Cell death & disease, 11(1):33. Nature Publishing Group
Cell Death & Disease

Hydrogen sulfide (H2S) is now widely considered the third endogenous gasotransmitter and plays critical roles in cancer biological processes. In this study, we demonstrate that 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione (ADT-OH), the most widely us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455238d9e8d560250ea7ea252ac62da7
https://doi.org/10.1038/s41419-020-2222-9

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