Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ningyan Hu"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
In a double homozygous mouse model of myotonic dystrophy type 1, Hu et al. use antisense oligonucleotide correction of myotonia to induce a therapeutic shift from an overabundance of oxidative muscle fibers to mechanically stronger glycolytic fibers.
Externí odkaz:
https://doaj.org/article/c2dc0c0869044b83a0ac3d3bf4e10a41
Autor:
Ningyan Hu, Eunjoo Kim, Layal Antoury, Jia Li, Paloma González-Pérez, Seward B. Rutkove, Thurman M. Wheeler
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 23, Iss , Pp 393-405 (2021)
Patients with myotonic dystrophy type 1 (DM1) identify chronic fatigue as the most debilitating symptom, which manifests in part as prolonged recovery after exercise. Clinical features of DM1 result from pathogenic gain-of-function activity of transc
Externí odkaz:
https://doaj.org/article/2bc669e95e604b4681f6fcb9a87c38ce
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 6, Iss 6, Pp 1106-1112 (2019)
Abstract In muscular dystrophies, identification of pathogenic pseudoexons involves sequencing of the target gene cDNA derived from muscle mRNA. Here we use a urine “liquid biopsy,” droplet digital PCR, and sequencing of PCR products to identify
Externí odkaz:
https://doaj.org/article/5b3c315c0d7e4b44a337cc07a461c6aa
Autor:
Ningyan Hu, Layal Antoury, Timothy M. Baran, Soumya Mitra, C. Frank Bennett, Frank Rigo, Thomas H. Foster, Thurman M. Wheeler
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Myotonic dystrophy type 1 (DM1) is associated with aberrant transcript splicing. Here, the authors develop a transgenic mouse model expressing a bi-chromatic reporter system that allows non-invasive monitoring of splicing of a transcript altered in D
Externí odkaz:
https://doaj.org/article/b1565fb81d1d487aac6b620c6b16e1b3
Autor:
Layal Antoury, Ningyan Hu, Leonora Balaj, Sudeshna Das, Sofia Georghiou, Basil Darras, Tim Clark, Xandra O. Breakefield, Thurman M. Wheeler
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Patients with myotonic dystrophy need to undergo invasive muscle biopsies to monitor disease progression and response to therapy. Here, the authors show that extracellular RNAs in human urine can be used as biomarkers to differentiate patients from u
Externí odkaz:
https://doaj.org/article/a34cd40d232146518807809a9a2dd9f6
Autor:
Preeti Kumari, Ningyan Hu, Alex Sizemore, Lauren Sullivan, Brigham Mckee, Parker Conquest, Thurman Wheeler
Publikováno v:
Tuesday, April 25.
Publikováno v:
Electroanalysis. 35
Autor:
Eunjoo Kim, Layal Antoury, Thurman M. Wheeler, Paloma Gonzalez-Perez, Seward B. Rutkove, Jia Li, Ningyan Hu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 23, Iss, Pp 393-405 (2021)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
Patients with myotonic dystrophy type 1 (DM1) identify chronic fatigue as the most debilitating symptom, which manifests in part as prolonged recovery after exercise. Clinical features of DM1 result from pathogenic gain-of-function activity of transc
Autor:
Lijin Zou, Youlai Zhang, Ying He, Hui Yu, Fan Yang, Jian Huang, Fangjuan Li, Qianglong Sheng, Yeming Zhang, Yajun Li, Fei Chen, Guangqian Zhou, Xuenong Zou, Qingqing Wang, Hong-ye Zhou, Ningyan Hu, Yuanlin Zeng, Hong-jiang Wei, Yin Yu, Gang Wang
BackgroundRapid closure of open wound, either temporarily or perpetually, is recognized as the standard of care in patients with thermal burns. Human cadaveric allograft and simple genetically modified porcine xenografts are not able to provide enoug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7603fabf0f1214ea344842f171e4654b
https://doi.org/10.1101/2021.12.30.21267448
https://doi.org/10.1101/2021.12.30.21267448
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 6, Iss 6, Pp 1106-1112 (2019)
Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology
In muscular dystrophies, identification of pathogenic pseudoexons involves sequencing of the target gene cDNA derived from muscle mRNA. Here we use a urine “liquid biopsy,” droplet digital PCR, and sequencing of PCR products to identify a novel c