Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Ningshu, Liu"'
Autor:
Ruicheng Wei, Wenli Zhang, Futang Yang, Qianhao Li, Qingyu Wang, Ningshu Liu, Jun Zhu, Yongqiang Shan
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Trastuzumab and pertuzumab combination has been approved for the treatment of patients with HER2-positive metastatic breast cancer. However, trastuzumab and pertuzumab combination did not show improvement in overall survival in pa
Externí odkaz:
https://doaj.org/article/8ea85c57cd15450fbf584a73612a1de6
Autor:
Zhi Qi, Zihan Xu, Liuzhen Zhang, Yongkang Zou, Jinping Li, Wenyu Yan, Cheng Li, Ningshu Liu, Hong Wu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Limited response to immune checkpoint inhibitors has been reported in patients with castration-resistant prostate cancer. Here the authors show that intermittent, but not continuous, treatment with an anti-PI3Kα/β/δ-inhibitor promotes anti-tumor i
Externí odkaz:
https://doaj.org/article/10d0bcbff27a44d084d7bcd464438339
Autor:
Richard Hill, Patricia A. Madureira, Bibiana Ferreira, Inês Baptista, Susana Machado, Laura Colaҫo, Marta dos Santos, Ningshu Liu, Ana Dopazo, Selma Ugurel, Angyal Adrienn, Endre Kiss-Toth, Murat Isbilen, Ali O. Gure, Wolfgang Link
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/09cb3cdd535740fb87f2aab84021359e
Autor:
Richard Hill, Patricia A. Madureira, Bibiana Ferreira, Inês Baptista, Susana Machado, Laura Colaço, Marta dos Santos, Ningshu Liu, Ana Dopazo, Selma Ugurel, Angyal Adrienn, Endre Kiss-Toth, Murat Isbilen, Ali O. Gure, Wolfgang Link
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Abstract Intrinsic and acquired resistance to chemotherapy is the fundamental reason for treatment failure for many cancer patients. The identification of molecular mechanisms involved in drug resistance or sensitization is imperative. Here we report
Externí odkaz:
https://doaj.org/article/176359cfd25c4c82970d73e492cb40ae
Autor:
Karl Ziegelbauer, Dominik Mumberg, William J. Scott, Scott M. Wilhelm, Martin Hentemann, Dean P. Wilkie, Paul R. Fracasso, Christoph A. Schatz, Andrea Haegebarth, Claudia Schneider, Cathy O. Bull, Bruce R. Rowley, Ningshu Liu
Supplementary Materials and Methods. Supplemental Table S1. Combination effects of BAY 80-6946 and lapatinib on caspase 9 activation in BT474 cells. Supplemental Table S2. Single dose i.v. pharmacokinetic parameter of BAY 80-6946 in female nude rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1474ccb7f22408bd87b65c4e0d64c418
https://doi.org/10.1158/1535-7163.22498903.v1
https://doi.org/10.1158/1535-7163.22498903.v1
Autor:
Neal Rosen, Sarat Chandarlapaty, Ningshu Liu, José Baselga, Elisa de Stanchina, Xuejun Jiang, Prashant Monian, Xiaodong Huang, Claudia Schneider, Vanessa Rodrik-Outmezguine, Zhan Yao, Weiyi Toy, Alice Can Ran Qin, Marie Will
The effects of selective phosphoinositide 3-kinase (PI3K) and AKT inhibitors were compared in human tumor cell lines in which the pathway is dysregulated. Both caused inhibition of AKT, relief of feedback inhibition of receptor tyrosine kinases, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91cb145c784d87d6d9bae733b069e129
https://doi.org/10.1158/2159-8290.c.6546140.v1
https://doi.org/10.1158/2159-8290.c.6546140.v1
Autor:
Neal Rosen, Sarat Chandarlapaty, Ningshu Liu, José Baselga, Elisa de Stanchina, Xuejun Jiang, Prashant Monian, Xiaodong Huang, Claudia Schneider, Vanessa Rodrik-Outmezguine, Zhan Yao, Weiyi Toy, Alice Can Ran Qin, Marie Will
PDF file 93K, This file contains detailed description of experimental procedures as well as reagents utilized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70381ca067d022a4465da17df9906051
https://doi.org/10.1158/2159-8290.22530248
https://doi.org/10.1158/2159-8290.22530248
Autor:
Hong Wu, Ningshu Liu, Tanu Shenoy, Marcus Ruscetti, Liuzhen Zhang, Weilong Guo, Zhi Qi, Yongkang Zou
Figure S1. Effects of BAY1082439 on cell apoptosis and cell cycle; Figure S2. BAY1082439 is well tolerated in vivo; Figure S3. BAY1082439 treatment impedes prostate tumor invasion; Figure S4. BAY1082439 treatment inhibit CRPC growth in castrated CP m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03ec0d180dcf79cb3760387d0df322db
https://doi.org/10.1158/1535-7163.22504362
https://doi.org/10.1158/1535-7163.22504362
Autor:
Neal Rosen, Sarat Chandarlapaty, Ningshu Liu, José Baselga, Elisa de Stanchina, Xuejun Jiang, Prashant Monian, Xiaodong Huang, Claudia Schneider, Vanessa Rodrik-Outmezguine, Zhan Yao, Weiyi Toy, Alice Can Ran Qin, Marie Will
PDF file 40K, Supplementary Figure S6. Induction of apoptosis by PI3K inhibition in HER2-amplified cells. Related to main Figure 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aeddd3a726f9efcced02e8eb21b7348
https://doi.org/10.1158/2159-8290.22530254.v1
https://doi.org/10.1158/2159-8290.22530254.v1
Autor:
Hong Wu, Ningshu Liu, Tanu Shenoy, Marcus Ruscetti, Liuzhen Zhang, Weilong Guo, Zhi Qi, Yongkang Zou
Targeting the PI3K pathway is a promising strategy for treating prostate cancers with PTEN-loss. However, current anti-PI3K therapies fail to show long lasting in vivo effects. We find that not only the PI3Kα- and PI3kβ-isoforms, but also PI3Kδ, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f4bb1d8c431596137b09588702b9d0a
https://doi.org/10.1158/1535-7163.c.6537711
https://doi.org/10.1158/1535-7163.c.6537711