Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Ningqiang Gong"'
Autor:
Xuexiang Han, Junchao Xu, Ying Xu, Mohamad-Gabriel Alameh, Lulu Xue, Ningqiang Gong, Rakan El-Mayta, Rohan Palanki, Claude C. Warzecha, Gan Zhao, Andrew E. Vaughan, James M. Wilson, Drew Weissman, Michael J. Mitchell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The ionizable lipidoid is a key component of lipid nanoparticles (LNPs). Degradable lipidoids containing extended alkyl branches have received tremendous attention, yet their optimization and investigation are underappreciated. Here, we devi
Externí odkaz:
https://doaj.org/article/5c7c469fc7ef44afbf32232dfd7a12e4
Autor:
Lulu Xue, Alex G. Hamilton, Gan Zhao, Zebin Xiao, Rakan El-Mayta, Xuexiang Han, Ningqiang Gong, Xinhong Xiong, Junchao Xu, Christian G. Figueroa-Espada, Sarah J. Shepherd, Alvin J. Mukalel, Mohamad-Gabriel Alameh, Jiaxi Cui, Karin Wang, Andrew E. Vaughan, Drew Weissman, Michael J. Mitchell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Lipid nanoparticles for delivering mRNA therapeutics hold immense promise for the treatment of a wide range of lung-associated diseases. However, the lack of effective methodologies capable of identifying the pulmonary delivery profile of ch
Externí odkaz:
https://doaj.org/article/5610f990ab3349ad8170012a73e2cbb4
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/f0b98b406ce74f1389d2cb9a059c3d29
Autor:
Kamila Butowska, Xuexiang Han, Ningqiang Gong, Rakan El-Mayta, Rebecca M. Haley, Lulu Xue, Wenqun Zhong, Wei Guo, Karin Wang, Michael J. Mitchell
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 4, Pp 1429-1437 (2023)
Evasion of apoptosis is a hallmark of cancer, attributed in part to overexpression of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2). In a variety of cancer types, including lymphoma, Bcl-2 is overexpressed. Therapeutic targeting of Bcl-2 has d
Externí odkaz:
https://doaj.org/article/ed334e7eb9604a24bf63a6a47cd80494
Autor:
Xiaolei Chen, Ruijie Deng, Dongdong Su, Xiaochen Ma, Xu Han, Shizheng Wang, Yuqing Xia, Zifu Yang, Ningqiang Gong, Yanwei Jia, Xueyun Gao, Xiaojun Ren
Publikováno v:
Exploration, Vol 3, Iss 5, Pp n/a-n/a (2023)
Abstract Gliomas are histologically and genetically heterogeneous tumors. However, classical histopathological typing often ignores the high heterogeneity of tumors and thus cannot meet the requirements of precise pathological diagnosis. Here, proxim
Externí odkaz:
https://doaj.org/article/5c15e10989c74c2fb1ae92743d2b7d86
Autor:
Xuexiang Han, Ningqiang Gong, Lulu Xue, Margaret M. Billingsley, Rakan El-Mayta, Sarah J. Shepherd, Mohamad-Gabriel Alameh, Drew Weissman, Michael J. Mitchell
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Gene delivery to fibroblasts for liver fibrosis treatment remains challenging. Here the authors develop a combinatorial library of ligand-tethered lipidoids via a modular synthetic method and adopt a 2-round screening strategy to identify lipidoids f
Externí odkaz:
https://doaj.org/article/81996ac972bd4186941bbb28373c56ae
Autor:
Yongchao Wang, Ningqiang Gong, Chi Ma, Yuxuan Zhang, Hong Tan, Guangchao Qing, Jimei Zhang, Yufei Wang, Jinjin Wang, Shizhu Chen, Xianlei Li, Qiankun Ni, Yuan Yuan, Yaling Gan, Junge Chen, Fangzhou Li, Jinchao Zhang, Caiwen Ou, Yongxiang Zhao, Xiaoxuan Liu, Xing-Jie Liang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Immunological adjuvants are a crucial component of cancer vaccines. Here the authors design a light-activable immunological adjuvant, based on hypoxia-responsive amphiphilic dendrimer nanoparticles loaded with a photodynamic agent, promoting anti-tum
Externí odkaz:
https://doaj.org/article/9406f8b05e734a97845b344a34803f0b
Autor:
Guangchao Qing, Xianxian Zhao, Ningqiang Gong, Jing Chen, Xianlei Li, Yaling Gan, Yongchao Wang, Zhen Zhang, Yuxuan Zhang, Weisheng Guo, Yang Luo, Xing-Jie Liang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Antibiotic resistance is a major global health challenge. Here, the authors report on a thermoresponsive delivery system for combined photothermal and antibiotic delivery with fluorescent tracking abilities and demonstrate application against antibio
Externí odkaz:
https://doaj.org/article/e07913e02ed249c4b04fd42124a95546
Autor:
Rebecca M. Haley, Alexander Chan, Margaret M. Billingsley, Ningqiang Gong, Marshall S. Padilla, Emily H. Kim, Hejia Wang, Dingzi Yin, Kirk J. Wangensteen, Andrew Tsourkas, Michael J. Mitchell
Publikováno v:
ACS Applied Materials & Interfaces. 15:21877-21892
Autor:
Patel, Savan K., Billingsley, Margaret M., Mukalel, Alvin J., Thatte, Ajay S., Hamilton, Alex G., Ningqiang Gong, El-Mayta, Rakan, Safford, Hannah C., Merolle, Maria, Mitchell, Michael J.
Publikováno v:
Theranostics; 2024, Vol. 14 Issue 1, p1-16, 16p