Interleukin-33 Contributes Toward Loss of Tolerance by Promoting B-Cell-Activating Factor of the Tumor-Necrosis-Factor Family (BAFF)-Dependent Autoantibody Production

Autor: William A. Rose, Angela J. Okragly, Ningjie N. Hu, Montanea R. Daniels, Andrea P. Martin, Yi Ting Koh, Kristine Kikly, Robert J. Benschop

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Breaking tolerance is a key event leading to autoimmunity, but the exact mechanisms responsible for this remain uncertain. Here we show that the alarmin IL-33 is able to drive the generation of autoantibodies through induction of the B cell survival

Externí odkaz: https://doaj.org/article/d1228f9ab1f94cada93acf6e5a47d8bd

A humanized CD3ε-knock-in mouse model for pre-clinical testing of anti-human CD3 therapy.

Autor: Crespo J; Immunology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, United States of America., Koh YT; Immunology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, United States of America., Hu N; Immunology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, United States of America., Moore PA; MacroGenics, Rockville, MD, United States of America., Bonvini E; MacroGenics, Rockville, MD, United States of America., Glasebrook AL; Immunology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, United States of America., Martin AP; Immunology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, United States of America., Benschop RJ; Immunology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, United States of America.

Publikováno v: PloS one [PLoS One] 2021 Feb 17; Vol. 16 (2), pp. e0245917. Date of Electronic Publication: 2021 Feb 17 (Print Publication: 2021).

Antiretroviral Therapy Normalizes Autoantibody Profile of HIV Patients by Decreasing CD33⁺CD11b⁺HLA-DR⁺ Cells: A Cross-Sectional Study.

Autor: Meng Z; From the Oncology Bioinformatics Center, Minhang Hospital, Fudan University (ZM, LD); Shanghai, China; Department of Microbiology and Immunology and Center for AIDS Research, Indiana University School of Medicine, Indianapolis, Indiana, USA (ZM, DB, TA, NS, JL, QY); Zhejiang Provincial Key Laboratory for Technology and Application of Model Organisms, Wenzhou Medical University, University Park, Wenzhou, China (NH); Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN (MD, SG, QY); and Department of Surgery, Davis Heart and Lung Research Institute, Biomedical Sciences Graduate Program, Biophysics Graduate Program, The Ohio State University Wexner Medical Center, Columbus, OH, USA (RH)., Du L, Hu N, Byrd D, Amet T, Desai M, Shepherd N, Lan J, Han R, Yu Q

Publikováno v: Medicine [Medicine (Baltimore)] 2016 Apr; Vol. 95 (15), pp. e3285.

Provirus activation plus CD59 blockage triggers antibody-dependent complement-mediated lysis of latently HIV-1-infected cells.

Autor: Lan J; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202; Center for AIDS Research, Indiana University School of Medicine, Indianapolis, IN 46202;, Yang K; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202; Center for AIDS Research, Indiana University School of Medicine, Indianapolis, IN 46202; Zhejiang Provincial Key Laboratory for Technology and Application of Model Organisms, Wenzhou Medical College, Wenzhou 325035, China;, Byrd D; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202; Center for AIDS Research, Indiana University School of Medicine, Indianapolis, IN 46202;, Hu N; Zhejiang Provincial Key Laboratory for Technology and Application of Model Organisms, Wenzhou Medical College, Wenzhou 325035, China;, Amet T; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202; Center for AIDS Research, Indiana University School of Medicine, Indianapolis, IN 46202;, Shepherd N; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202; Center for AIDS Research, Indiana University School of Medicine, Indianapolis, IN 46202;, Desai M; Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202; and., Gao J; Zhejiang Provincial Key Laboratory for Technology and Application of Model Organisms, Wenzhou Medical College, Wenzhou 325035, China;, Gupta S; Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202; and., Sun Y; Department of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China., Yu Q; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202; Center for AIDS Research, Indiana University School of Medicine, Indianapolis, IN 46202; Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202; and andyu@iupui.edu.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2014 Oct 01; Vol. 193 (7), pp. 3577-89. Date of Electronic Publication: 2014 Aug 22.

HIV-1 coinfection profoundly alters intrahepatic chemokine but not inflammatory cytokine profiles in HCV-infected subjects.

Autor: Hu S; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America ; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China., Ghabril M; Division of Gastroenterology/Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America., Amet T; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America., Hu N; Zhejiang Provincial Key Laboratory for Technology & Application of Model Organisms, Wenzhou Medical College, Wenzhou, Zhejiang, China., Byrd D; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America., Yang K; Zhejiang Provincial Key Laboratory for Technology & Application of Model Organisms, Wenzhou Medical College, Wenzhou, Zhejiang, China., Vuppalanchi R; Division of Gastroenterology/Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America., Saxena R; Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America., Desai M; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America ; Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America., Lan J; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America., Johnson R; Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America., Gupta S; Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America., Chalasani N; Division of Gastroenterology/Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America., Yu Q; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America ; Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America ; Center for AIDS Research, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.

Publikováno v: PloS one [PLoS One] 2014 Feb 06; Vol. 9 (2), pp. e86964. Date of Electronic Publication: 2014 Feb 06 (Print Publication: 2014).