Zobrazeno 1 - 10 of 51 pro vyhledávání: '"Ningguo Gao"'
1
Akademický článek
A zebrafish model of congenital disorders of glycosylation with phosphomannose isomerase deficiency reveals an early opportunity for corrective mannose supplementation
Autor: Jaime Chu, Alexander Mir, Ningguo Gao, Sabrina Rosa, Christopher Monson, Vandana Sharma, Richard Steet, Hudson H. Freeze, Mark A. Lehrman, Kirsten C. Sadler
Publikováno v: Disease Models & Mechanisms, Vol 6, Iss 1, Pp 95-105 (2013)
SUMMARY Individuals with congenital disorders of glycosylation (CDG) have recessive mutations in genes required for protein N-glycosylation, resulting in multi-systemic disease. Despite the well-characterized biochemical consequences in these individ
Externí odkaz: https://doaj.org/article/294b374090034630ba6dfa33c2843e27
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2
Akademický článek
Antiangiogenic activity of 2-deoxy-D-glucose.
Autor: Jaime R Merchan, Krisztina Kovács, Jaclyn W Railsback, Metin Kurtoglu, Yuqi Jing, Yolanda Piña, Ningguo Gao, Timothy G Murray, Mark A Lehrman, Theodore J Lampidis
Publikováno v: PLoS ONE, Vol 5, Iss 10, p e13699 (2010)
During tumor angiogenesis, endothelial cells (ECs) are engaged in a number of energy consuming biological processes, such as proliferation, migration, and capillary formation. Since glucose uptake and metabolism are increased to meet this energy need
Externí odkaz: https://doaj.org/article/1a87ae1e5f1b4f9ea8df589895b9e1e0
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3
Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells
Autor: Jennifer E. Golden, Natalie Rinis, Timothy A. Lewis, Lance Wells, Cecilia Lopez-Sambrooks, Jonathan Charest, Reid Gilmore, Ningguo Gao, Carol Khodier, Mark A. Lehrman, Peng Zhao, Joseph N. Contessa, Daniel P. Flaherty, Shiteshu Shrimal
Publikováno v: Nature Chemical Biology. 12:1023-1030
Asparagine (N)-linked glycosylation is a protein modification critical for glycoprotein folding, stability, and cellular localization. To identify small molecules that inhibit new targets in this biosynthetic pathway, we initiated a cell-based high-t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::586c40d40f27b87f5c7be3cf2d3513a9
https://doi.org/10.1038/nchembio.2194
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4
trappc11is required for protein glycosylation in zebrafish and humans
Autor: Charles DeRossi, Daniela Stanga, Dhara Kadakia, Mark A. Lehrman, Ruhina Rafiq, Ningguo Gao, Shikha Nayar, Ana M. Vacaru, Dru Imrie, Hudson H. Freeze, Michael Sacher, Kirsten C. Sadler, Anastasia Baryshnikova, Ayca Cinaroglu, Miroslav P. Milev, Jaime Chu
Publikováno v: Molecular Biology of the Cell
The trappc11 mutation in zebrafish causes a stressed UPR, leading to fatty liver disease. This phenotype is not due to a trafficking defect but instead results from N-glycosylation defects. Hypoglycosylation and lipid accumulation are also found in p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a0fcb100c17ddc0ad70d2ddfdbd3fe
https://doi.org/10.1091/mbc.e15-08-0557
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5
Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation
Autor: Tomomi Sakai, John P. Atkinson, Sixin Jiang, Herbert C. Morse, Ningguo Gao, Mark A. Lehrman, Nan Yan, Quan Zhen Li, Takuya Miyazaki, Charles S. Fermaintt, Maroof Hasan
Publikováno v: Immunity. 43:463-474
SummaryTREX1 is an endoplasmic reticulum (ER)-associated negative regulator of innate immunity. TREX1 mutations are associated with autoimmune and autoinflammatory diseases. Biallelic mutations abrogating DNase activity cause autoimmunity by allowing
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54aab123f3b0a35ddae06449c3f30425
https://doi.org/10.1016/j.immuni.2015.07.022
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6
Spliced X-Box Binding Protein 1 Couples the Unfolded Protein Response to Hexosamine Biosynthetic Pathway
Autor: Anwarul Ferdous, Ningguo Gao, Alfredo Criollo, Wei Tan, Sergio Lavandero, Philipp E. Scherer, Thomas G. Gillette, Beverly A. Rothermel, Yingfeng Deng, Zully Pedrozo, Joseph A. Hill, Xiang Luo, Mark A. Lehrman, Zhao V. Wang, Nan Jiang, Cyndi R. Morales, Ann-Hwee Lee, Pradeep P.A. Mammen, Dan L. Li
Publikováno v: CELL (CAMBRIDGE)
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
SummaryThe hexosamine biosynthetic pathway (HBP) generates uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) for glycan synthesis and O-linked GlcNAc (O-GlcNAc) protein modifications. Despite the established role of the HBP in metabolism and multi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a69f01655455cca0b022190da3edc43c
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7
Glycoprotein Biosynthesis in a Eukaryote Lacking the Membrane Protein Rft1*
Autor: Peter Bütikofer, James D. Bangs, Mark A. Lehrman, Ningguo Gao, Remo S. Schmidt, Anant K. Menon, Jennifer Jelk, Aita Signorell, Alvaro Acosta-Serrano, Mauro Serricchio
Publikováno v: The Journal of Biological Chemistry
Jelk, Jennifer; Gao, Ningguo; Serricchio, Mauro; Signorell, Aita; Schmidt, Remo; Bangs, James D; Acosta-Serrano, Alvaro; Lehrman, Mark A; Bütikofer, Peter; Menon, Anant K (2013). Glycoprotein biosynthesis in a eukaryote lacking the membrane protein Rft1. Journal of biological chemistry, 288(28), pp. 20616-23. American Society for Biochemistry and Molecular Biology 10.1074/jbc.M113.479642
The Journal of biological chemistry
Background: The membrane protein Rft1 was proposed to flip Man5GlcNAc2-PP-dolichol (M5-DLO) to the ER lumen for N-glycoprotein biosynthesis. Results: Rft1-null Trypanosoma brucei has a normal steady-state level of mature dolichol-linked oligosacchari
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3f771bb8753b5cb655694201e17be40
http://europepmc.org/articles/PMC3711325
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8
A zebrafish model of congenital disorders of glycosylation with phosphomannose isomerase deficiency reveals an early opportunity for corrective mannose supplementation
Autor: Richard Steet, Sabrina Rosa, Ningguo Gao, Jaime Chu, Mark A. Lehrman, Vandana Sharma, Kirsten C. Sadler, Christopher Monson, Alexander Mir, Hudson H. Freeze
Publikováno v: Disease Models & Mechanisms, Vol 6, Iss 1, Pp 95-105 (2013)
Disease Models & Mechanisms
Summary Individuals with congenital disorders of glycosylation (CDG) have recessive mutations in genes required for protein N-glycosylation, resulting in multi-systemic disease. Despite the well-characterized biochemical consequences in these individ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f519f6606cfe0a8858b662f0249518d
http://dmm.biologists.org/content/6/1/95
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9
5-Thiomannosides Block the Biosynthesis of Dolichol-Linked Oligosaccharides and Mimic Class I Congenital Disorders of Glycosylation
Autor: Jayakanthan Kumarasamy, Mark A. Lehrman, B. Mario Pinto, Nabil G. Seidah, Ningguo Gao, Wesley F. Zandberg
Publikováno v: ChemBioChem. 13:392-401
In a cell-based assay for novel inhibitors, we have discovered that two glycosides of 5-thiomannose, each containing an interglycosidic nitrogen atom, prevented the correct zymogen processing of the prohormone proopiomelanocortinin (POMC) and the tra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d1f46447a5be9931341c85fe294629
https://doi.org/10.1002/cbic.201100647
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10
Nogo-B receptor is necessary for cellular dolichol biosynthesis and proteinN-glycosylation
Autor: William C. Sessa, Jeffrey S. Rush, Kenneth D. Harrison, Eon Joo Park, Andrew Kuo, Ningguo Gao, Charles J. Waechter, Mark A. Lehrman
Publikováno v: The EMBO Journal. 30:2490-2500
Dolichol monophosphate (Dol-P) functions as an obligate glycosyl carrier lipid in protein glycosylation reactions. Dol-P is synthesized by the successive condensation of isopentenyl diphosphate (IPP), with farnesyl diphosphate catalysed by a cis-isop
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5758a4b816a2d7c6080dff376966bf3
https://doi.org/10.1038/emboj.2011.147
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