Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Ning Yu Wang"'
Autor:
Li Liu, Ting Hong Ye, Yuan Ping Han, Hang Song, Yong Kui Zhang, Yong Xia, Ning Yu Wang, Ying Xiong, Xue Jiao Song, Yong Xia Zhu, De Liang Li, Jun Zeng, Kai Ran, Cui Ting Peng, Yu Quan Wei, Luo Ting Yu
Publikováno v:
Cellular Physiology and Biochemistry, Vol 33, Iss 3, Pp 633-645 (2014)
Background: AZD4547, a small-molecule inhibitor targeting the tyrosine kinase of Fibroblast Growth Factor Receptors (FGFRs), is currently under phase II clinical study for human subjects having breast cancer, while the underlying mechanism remains el
Externí odkaz:
https://doaj.org/article/66ec7cf45342446c81dfbe745defe145
Autor:
Xiao-ting Li, Ning-yu Wang, Yan-jun Wang, Zhi-qing Xu, Jin-feng Liu, Yun-fei Bai, Jin-sheng Dai, Jing-yi Zhao
Publikováno v:
Neural Regeneration Research, Vol 11, Iss 5, Pp 787-794 (2016)
The γ-aminobutyric acid neurons (GABAergic neurons) in the inferior colliculus are classified into various patterns based on their intrinsic electrical properties to a constant current injection. Although this classification is associated with physi
Externí odkaz:
https://doaj.org/article/b43f46931a714727af297e24f8294979
Autor:
Cui-Ting Peng, Li Liu, Chang-Cheng Li, Li-Hui He, Tao Li, Ya-Lin Shen, Chao Gao, Ning-Yu Wang, Yong Xia, Yi-Bo Zhu, Ying-Jie Song, Qian Lei, Luo-Ting Yu, Rui Bao
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
PepP is a virulence-associated gene in Pseudomonas aeruginosa, making it an attractive target for anti-P. aeruginosa drug development. The encoded protein, aminopeptidases P (Pa-PepP), is a type of X-prolyl peptidase that possesses diverse biological
Externí odkaz:
https://doaj.org/article/407c72f661b64c989ff685b46822c66c
Autor:
Zhi-Tong Fan, Zi-Hui Zhao, Mridula Sharma, Joaquin T. Valderrama, Qian-Jie Fu, Jia-Xing Liu, Xin Fu, Huan Li, Xue-Lei Zhao, Xin-Yu Guo, Luo-Yi Fu, Ning-Yu Wang, Juan Zhang
Publikováno v:
Frontiers in Neuroscience. 16
Acoustic change complex (ACC) is a cortical auditory-evoked potential induced by a change of continuous sound stimulation. This study aimed to explore: (1) whether the change of horizontal sound location can elicit ACC; (2) the relationship between t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb1a0586738c2f9108adc5ec14231a6
https://doi.org/10.3389/fnins.2022.908989
https://doi.org/10.3389/fnins.2022.908989
Publikováno v:
Pharmaceutical Chemistry Journal. 55:36-45
Cell-based screening of a privileged small molecule library led to the discovery of 9-sulfonyl-9(H)-purine as new scaffold for hepatitis C virus (HCV) inhibitors. Structure–activity relationship study with respect to the 2-, 6- and 9-positions in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5739b3ac0a532b3caf7d3a093e0087bf
https://doi.org/10.1007/s11094-021-02369-1
https://doi.org/10.1007/s11094-021-02369-1
Autor:
Yongxia Zhu, Rong Hu, Tinghong Ye, Xiuli Wu, Wei Wei, Hualong He, Luoting Yu, Xi Hu, Qi-Wei Wang, Zhihao Liu, Ning-Yu Wang, Xingping Su, Shu-Yan Zhou, Qiangsheng Zhang
Publikováno v:
Journal of Medicinal Chemistry. 64:2829-2848
EZH2 mediates both PRC2-dependent gene silencing via catalyzing H3K27me3 and PRC2-independent transcriptional activation in various cancers. Given its oncogenic role in cancers, EZH2 has constituted a compelling target for anticancer therapy. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f022e38cdc5a2c6fcf0ef98210608254
https://doi.org/10.1021/acs.jmedchem.0c02234
https://doi.org/10.1021/acs.jmedchem.0c02234
Autor:
Jia-Qi Chen, Kai-Dong Chen, Zai-Bin Cheng, Chunwang He, Qiu-Hai Lu, Xiao-Yu Zhong, Jia-Peng Liu, Ning-Yu Wang, Wen-Jun Huang
Publikováno v:
Structural and Multidisciplinary Optimization. 63:881-896
For decades, the slide drilling system (SDS) has played a critical role in the area of directional drilling. Drilling in the sliding mode is much more time-consuming than drilling in the rotating mode for a SDS. Therefore, it generally takes more tim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e307ae6dff333a88d29cd4585e2b991d
https://doi.org/10.1007/s00158-020-02732-y
https://doi.org/10.1007/s00158-020-02732-y
Autor:
Ying-Yue Yang, Wan-Li Wang, Xia-Tong Hu, Xin Chen, Yang Ni, Yan-Hua Lei, Qi-Yuan Qiu, Long-Yue Tao, Tian-Wen Luo, Ning-Yu Wang
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::321120f2ccef70f09d7e0d8b2c5a713e
https://doi.org/10.2139/ssrn.4219000
https://doi.org/10.2139/ssrn.4219000
Autor:
Yongxia Zhu, Qiangsheng Zhang, Luoting Yu, Ning-Yu Wang, Zhihao Liu, Lu Li, Qiang Feng, Lidan Zhang, Guoquan Wan, Xi Hu
Publikováno v:
Chemical communications (Cambridge, England). 57(24)
By targeting the unique Cys663 of EZH2, SKLB-0335 displays high paralog-selectivity on EZH2. Biochemical studies show that SKLB-0335 can covalently bind to EZH2 at its S-adenosylmethionine (SAM) pocket and inhibit H3K27Me3. SKLB-0335 could be an effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eeb8ddb60800e1536b228a5a42d2df2
https://pubmed.ncbi.nlm.nih.gov/33623946
https://pubmed.ncbi.nlm.nih.gov/33623946
Autor:
Zhanzhan Feng, Jun Zeng, Wei Wei, Wang Xiang, Kai Ran, Xiang Hu, Ning-Yu Wang, Xiaojie He, Luoting Yu, Zhihao Liu, Guoquan Wan
Publikováno v:
European journal of medicinal chemistry. 220
Aberrant signaling of fibroblast growth factor receptors (FGFRs) has been identified as a driver of tumorigenesis and the development of many solid tumors, making FGFRs a compelling target for anticancer therapy. Herein, we describe the design and sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e460ca2aa5f19da678c177287508284
https://pubmed.ncbi.nlm.nih.gov/33940465
https://pubmed.ncbi.nlm.nih.gov/33940465