Zobrazeno 1 - 10
of 1 267
pro vyhledávání: '"Ning SHEN"'
Autor:
Ningyuan You, Chang Liu, Yuxin Gu, Rong Wang, Hanying Jia, Tianyun Zhang, Song Jiang, Jinsong Shi, Ming Chen, Min-Xin Guan, Siqi Sun, Shanshan Pei, Zhihong Liu, Ning Shen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract We present SpliceTransformer (SpTransformer), a deep-learning framework that predicts tissue-specific RNA splicing alterations linked to human diseases based on genomic sequence. SpTransformer outperforms all previous methods on splicing pre
Externí odkaz:
https://doaj.org/article/94d9c9e7fee1441fbb93d3011b9920e8
Autor:
Zhimei Lv, Ziyang Wang, Jinxiu Hu, Hong Su, Bing Liu, Yating Lang, Qun Yu, Yue Liu, Xiaoting Fan, Meilin Yang, Ning Shen, Dongdong Zhang, Xia Zhang, Rong Wang
Publikováno v:
Cell Death and Disease, Vol 15, Iss 9, Pp 1-15 (2024)
Abstract Mitochondrial dysfunction is a significant contributor to podocyte injury in diabetic kidney disease (DKD). While previous studies have shown that PVT1 might play a vital role in DKD, the precise molecular mechanisms are largely unknown. By
Externí odkaz:
https://doaj.org/article/68b52497c0bb48a5bf428c0312c15336
Autor:
Kejing Wu, Xingyu Lin, Yujie Lu, Rui Dong, Hongnian Jiang, Sarah L. Svensson, Jiajia Zheng, Ning Shen, Andrew Camilli, Yanjie Chao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Hypervirulent Klebsiella pneumoniae (HvKP) is an emerging bacterial pathogen causing invasive infection in immune-competent humans. The hypervirulence is strongly linked to the overproduction of hypermucoviscous capsule, but the underlying r
Externí odkaz:
https://doaj.org/article/ecd183053d9746b4b726f6f492c2f2d7
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
We identified a novel ceftazidime/avibactam (CAZ/AVI) resistance mechanism in endemic sequence type 11 hypervirulent and carbapenem-resistant Klebsiella pneumoniae isolated from a patient who had not been exposed CAZ/AVI. Overexpression of blaSHV-12
Externí odkaz:
https://doaj.org/article/476cadb15ba94923bf97ce6364a37089
Autor:
Ping Zhou, Bing Liu, Ning Shen, Xiaoting Fan, Shangwei Lu, Zhijuan Kong, Ying Gao, Zhimei Lv, Rong Wang
Publikováno v:
Renal Failure, Vol 46, Iss 1 (2024)
Background Immune checkpoint inhibitor-associated acute kidney injury (ICI-AKI) is the most common renal complication and has attracted increasing amounts of attention. However, studies on this topic in Chinese cancer patients are very limited. There
Externí odkaz:
https://doaj.org/article/dd4236719df04bf49189b973b43c3c0d
Autor:
Ning Shen, Shangwei Lu, Zhijuan Kong, Ying Gao, Jinxiu Hu, Shuxuan Si, Junlin Wang, Jie Li, Wei Han, Rong Wang, Zhimei Lv
Publikováno v:
Diabetology & Metabolic Syndrome, Vol 16, Iss 1, Pp 1-9 (2024)
Abstract Diabetic nephropathy (DN) is a critical inflammatory condition linked to diabetes, affecting millions worldwide. This study employs Mendelian randomization (MR) to explore the causal relationship between immune cell signatures and DN, analyz
Externí odkaz:
https://doaj.org/article/437906aa70a64c57af478de2425a24a3
Autor:
Xiaoting Fan, Meilin Yang, Yating Lang, Shangwei Lu, Zhijuan Kong, Ying Gao, Ning Shen, Dongdong Zhang, Zhimei Lv
Publikováno v:
Cell Death and Disease, Vol 15, Iss 6, Pp 1-12 (2024)
Abstract Diabetic kidney disease, known as a glomerular disease, arises from a metabolic disorder impairing renal cell function. Mitochondria, crucial organelles, play a key role in substance metabolism via oxidative phosphorylation to generate ATP.
Externí odkaz:
https://doaj.org/article/94b2795002ff45d6ac15b4b2ee815d3b
Autor:
Haishuai Wang, Hezi Jing, Jianjun Yang, Chao Liu, Liwei Hu, Guangyu Tao, Ziping Zhao, Ning Shen
Publikováno v:
npj Mental Health Research, Vol 3, Iss 1, Pp 1-8 (2024)
Abstract The application of deep learning models to precision medical diagnosis often requires the aggregation of large amounts of medical data to effectively train high-quality models. However, data privacy protection mechanisms make it difficult to
Externí odkaz:
https://doaj.org/article/7d5ef5fe268c45e7a84b6d73c295a4ea
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
BackgroundNeutrophil plays a pivotal role in the management of Klebsiella pneumoniae infection. Delineate the clinical characteristics and prognostic utility of neutrophil in severe patients with K. pneumoniae infection are crucial for clinical manag
Externí odkaz:
https://doaj.org/article/796ec5dc74ff468ca928de496e72887d
Autor:
Mengmeng Li, Jinsong Wang, Yanfeng Dong, Yanting Zeng, Ning Shen, Wenjie Liu, Zhu Tong, Hong Chen
Publikováno v:
Ecological Indicators, Vol 166, Iss , Pp 112190- (2024)
In cities, green infrastructure (GI) is a vital natural life support system that is intimately linked to the daily lives of citizens. High levels of Urban Green Infrastructure (UGI) can help mitigate a series of ecological problems faced by cities, w
Externí odkaz:
https://doaj.org/article/fbab4be4c8c445ac8e17ec7498ba0493