Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ninche Alston"'
Autor:
Gerardo G Mackenzie, Lauren E Bartels, Gang Xie, Ioannis Papayannis, Ninche Alston, Kvetoslava Vrankova, Nengtai Ouyang, Basil Rigas
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 10, Pp 1184-1195 (2013)
Pancreatic cancer has one of the poorest prognoses among all cancers partly because of its persistent resistance to chemotherapy. The currently limited treatment options for pancreatic cancer underscore the need for more efficient agents. Because act
Externí odkaz:
https://doaj.org/article/0612c5737e624398b867588793fe633e
Autor:
Gerardo G Mackenzie, Liqun Huang, Ninche Alston, Nengtai Ouyang, Kvetoslava Vrankova, George Mattheolabakis, Panayiotis P Constantinides, Basil Rigas
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e61532 (2013)
New agents are needed to treat pancreatic cancer, one of the most lethal human malignancies. We synthesized phospho-valproic acid, a novel valproic acid derivative, (P-V; MDC-1112) and evaluated its efficacy in the control of pancreatic cancer. P-V i
Externí odkaz:
https://doaj.org/article/5b8c44d22d1845ad9f8891e3cd659fed
Autor:
Basil Rigas, Timothy Wiedmann, Gang Xie, Nengtai Ouyang, Liqun Huang, Gerardo G. Mackenzie, Ninche Alston, Chi C. Wong, Ka Wing Cheng
PDF file - 883K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::157869e68c06019d5f87b3d24721f786
https://doi.org/10.1158/1535-7163.22500456
https://doi.org/10.1158/1535-7163.22500456
Autor:
Basil Rigas, Timothy Wiedmann, Gang Xie, Nengtai Ouyang, Liqun Huang, Gerardo G. Mackenzie, Ninche Alston, Chi C. Wong, Ka Wing Cheng
Phospho-sulindac is a sulindac derivative with promising anticancer activity in lung cancer, but its limited metabolic stability presents a major challenge for systemic therapy. We reasoned that inhalation delivery of phospho-sulindac might overcome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b4c32100c236fed9746ecb80127bdb0
https://doi.org/10.1158/1535-7163.c.6536460.v1
https://doi.org/10.1158/1535-7163.c.6536460.v1
Autor:
Liqun Huang, Ioannis Papayannis, Ka-Wing Cheng, Nengtai Ouyang, George Mattheolabakis, Chi Chun Wong, Ninche Alston, Ting Nie, Basil Rigas
Publikováno v:
International Journal of Pharmaceutics. 477:236-243
Phospho-non-steroidal anti-inflammatory drugs (phospho-NSAIDs) are a novel class of NSAID derivatives with potent antitumor activity. However, phospho-NSAIDs have limited stability in vivo due to their rapid hydrolysis by carboxylesterases at their c
Autor:
Kvetoslava Vrankova, Lauren E Bartels, Gang Xie, Ninche Alston, Gerardo G. Mackenzie, Ioannis Papayannis, Basil Rigas, Nengtai Ouyang
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 10, Pp 1184-1195 (2013)
Pancreatic cancer has one of the poorest prognoses among all cancers partly because of its persistent resistance to chemotherapy. The currently limited treatment options for pancreatic cancer underscore the need for more efficient agents. Because act
Autor:
Liqun Huang, Nengtai Ouyang, Basil Rigas, Gang Xie, Ka-Wing Cheng, Timothy S. Wiedmann, Ninche Alston, Gerardo G. Mackenzie, Chi Chun Wong
Publikováno v:
Molecular Cancer Therapeutics. 12:1417-1428
Phospho-sulindac is a sulindac derivative with promising anticancer activity in lung cancer, but its limited metabolic stability presents a major challenge for systemic therapy. We reasoned that inhalation delivery of phospho-sulindac might overcome
Autor:
Ninche Alston, Chi Chun Wong, Gerardo G. Mackenzie, Liqun Huang, Nengtai Ouyang, Ioannis Papayannis, Ting Nie, Basil Rigas, Dingying Zhou
Publikováno v:
Carcinogenesis. 34:943-951
We have synthesized a novel derivative of indomethacin, phospho-tyrosol-indomethacin (PTI; MPI-621), and evaluated its anticancer efficacy in vitro and in vivo. PTI inhibited the growth of human colon, breast and lung cancer cell lines 6–30-fold mo
Publikováno v:
British Journal of Pharmacology. 166:991-1001
BACKGROUND AND PURPOSE Phospho-ibuprofen (P-I; MDC-917) inhibits the growth of colon cancer in mice. Here, we investigated the use of nanocarriers to improve its pharmacokinetics (PKs) and anti tumour efficacy. EXPERIMENTAL APPROACH The cellular upta
Autor:
Yu Sun, Onika T. Murray, Basil Rigas, Ninche Alston, Gerardo G. Mackenzie, Levy Kopelovich, Gang Xie, Nengtai Ouyang, Panayiotis P. Constantinides, Ting Nie, Caihua Zhu, Liqun Huang
Publikováno v:
British Journal of Pharmacology. 165:2152-2166
BACKGROUND AND PURPOSE Phospho-sulindac (PS; OXT-328) prevents colon cancer in mice, especially when combined with difluoromethylornithine (DFMO). Here, we explored its metabolism and pharmacokinetics. EXPERIMENTAL APPROACH PS metabolism was studied