Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Ninan Abraham"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Interleukin-7 (IL-7) is a cytokine known for its importance in T cell development and survival. How IL-7 shapes CD8 T cell responses during an acute viral infection is less understood. We had previously shown that IL-7 signaling deficient mi
Externí odkaz:
https://doaj.org/article/40004d580a92456d980acf42484e3609
Autor:
Etienne S. Melese, Elizabeth Franks, Rachel A. Cederberg, Bryant T. Harbourne, Rocky Shi, Brennan J. Wadsworth, Jenna L. Collier, Elizabeth C. Halvorsen, Fraser Johnson, Jennifer Luu, Min Hee Oh, Vivian Lam, Gerald Krystal, Shelley B. Hoover, Mark Raffeld, R. Mark Simpson, Arun M. Unni, Wan L. Lam, Stephen Lam, Ninan Abraham, Kevin L. Bennewith, William W. Lockwood
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Current immunotherapies for lung cancer are only effective in a subset of patients. Identifying tumor-derived factors that facilitate immunosuppression offers the opportunity to develop novel strategies to supplement and improve current therapeutics.
Externí odkaz:
https://doaj.org/article/2c2a00203bef4e89885342925d64134f
Autor:
Abdalla Sheikh, Ninan Abraham
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Innate lymphoid cells (ILCs) are a group of immune cells that are important for defense against pathogens, tissue repair, and lymphoid organogenesis. They share similar characteristics with various subsets of helper T cells but lack specific antigen
Externí odkaz:
https://doaj.org/article/c548d818cc494362be3f53eff7f6ce8a
Autor:
Kevin W Ng, Erin A Marshall, Katey SS Enfield, Spencer D Martin, Katy Milne, Michelle E Pewarchuk, Ninan Abraham, Wan L Lam
Publikováno v:
OncoImmunology, Vol 7, Iss 12 (2018)
T follicular helper cells (Tfh) play crucial roles in the development of humoral immunity. In the B cell-rich germinal center of lymphoid organs, they select for high-affinity B cells and aid in their maturation. While Tfh have known roles in B cell
Externí odkaz:
https://doaj.org/article/1693684fd5994a61a6437b2678b2d8ea
Autor:
Maryam Ghaedi, Catherine A. Steer, Itziar Martinez-Gonzalez, Timotheus Y.F. Halim, Ninan Abraham, Fumio Takei
Publikováno v:
Cell Reports, Vol 15, Iss 3, Pp 471-480 (2016)
All lymphocytes are thought to develop from common lymphoid progenitors (CLPs). However, lymphoid-primed multipotent progenitors (LMPPs) are more efficient than CLPs in differentiating into T cells and group 2 innate lymphoid cells (ILC2s). Here, we
Externí odkaz:
https://doaj.org/article/3bcc3aa0acce4789bcc6a9bb4c397fc1
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
Current influenza vaccines generate humoral immunity, targeting highly variable epitopes and thus fail to achieve long-term protection. T cells recognize and respond to several highly conserved epitopes across influenza serotypes. A strategy of raisi
Externí odkaz:
https://doaj.org/article/e6dc1d16c03a4aab8dbce410a4b5aa20
Autor:
Daniel T Patton, Adam W Plumb, Stephen A Redpath, Lisa C Osborne, Georgia Perona-Wright, Ninan Abraham
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88771 (2014)
IL-7 is a critical cytokine for lymphocyte development. Recent work has highlighted critical roles for IL-7 signaling in mature T cell homeostasis and function, but its role in B cells is less well characterized. Using a knock-in mouse possessing a T
Externí odkaz:
https://doaj.org/article/afb03060576e48a69e4e59db6b7c68a1
Autor:
Adam W Plumb, Daniel T Patton, Jung Hee Seo, Emma-Kate Loveday, François Jean, Steven F Ziegler, Ninan Abraham
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50199 (2012)
The immune response to viral infection is ideally rapid and specific, resulting in viral clearance and establishment of immune memory. Some viruses such as HIV can evade such responses leading to chronic infection, while others like Influenza A can e
Externí odkaz:
https://doaj.org/article/42273a0b5e1941dd95445c45a5753f34
Publikováno v:
Journal of Leukocyte Biology. 112:1105-1113
Interleukin-7 is a cytokine with well-established roles in lymphocyte development and more recently, an expanded role in immune function. IL-7Rα is highly expressed by innate lymphoid cells (ILCs), but how IL-7 directs the development or function of
Autor:
C. Satheesh Kumar, Emil Ninan Abraham
Publikováno v:
Calcutta Statistical Association Bulletin. 74:7-26
Here we propose a zero-truncated version of the alternative hyper-Poisson distribution of Kumar and Nair[ 1 ] and study some of its statistical properties. We derive some of its essential properties such as mean, variance, probability generating func