Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ninad M Walavalkar"'
Autor:
Yunxian Liu, Ninad M Walavalkar, Mikhail G Dozmorov, Stephen S Rich, Mete Civelek, Michael J Guertin
Publikováno v:
PLoS Genetics, Vol 13, Iss 9, p e1006761 (2017)
Genome-wide association studies (GWAS) have discovered thousands loci associated with disease risk and quantitative traits, yet most of the variants responsible for risk remain uncharacterized. The majority of GWAS-identified loci are enriched for no
Externí odkaz:
https://doaj.org/article/eaa2d3ee0d064570bfd5fb317f55a212
Autor:
Arun B. Dutta, Daniel S. Lank, Róża K. Przanowska, Piotr Przanowski, Lixin Wang, Bao Nguyen, Ninad M. Walavalkar, Fabiana M. Duarte, Michael J. Guertin
Adipocytes contribute to metabolic disorders such as obesity, diabetes, and atherosclerosis. Prior characterizations of the transcriptional network driving adipogenesis have overlooked transiently acting transcription factors (TFs), genes, and regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::405a6dd13378ace555a676fd5641c5e4
https://doi.org/10.1101/2021.11.17.469040
https://doi.org/10.1101/2021.11.17.469040
Publikováno v:
Nucleic Acids Research
Coupling molecular biology to high throughput sequencing has revolutionized the study of biology. Molecular genomics techniques are continually refined to provide higher resolution mapping of nucleic acid interactions and structure. Sequence preferen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc012bb95e0d0a3aa8fadbc900d5b2be
Autor:
M. Jeannette Sperlazza, Deborah Pohlmann, Jeremy W. Prokop, Ninad M. Walavalkar, Fernando Gomez, Stephanie M. Bilinovich, Leslie Mark, Chelsea Hall, Benjamin Kornegay, David C. Williams, Edhriz Siraliev-Perez, Jason M. Cramer, April Hill
Publikováno v:
Scientific Reports
DNA cytosine methylation and methyl-cytosine binding domain (MBD) containing proteins are found throughout all vertebrate species studied to date. However, both the presence of DNA methylation and pattern of methylation varies among invertebrate spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e692ab74ba3d6ee87dc9ba86b64a5b4c
Autor:
J. Neel Scarsdale, Ninad M. Walavalkar, William A. Buchwald, Jason M. Cramer, David C. Williams
Publikováno v:
Nucleic Acids Research
Unlike other members of the methyl-cytosine binding domain (MBD) family, MBD4 serves as a potent DNA glycosylase in DNA mismatch repair specifically targeting mCpG/TpG mismatches arising from spontaneous deamination of methyl-cytosine. The protein co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6845b14822f9732d88fdde063497810a
https://doi.org/10.1093/nar/gku782
https://doi.org/10.1093/nar/gku782
Autor:
William A. Buchwald, Gordon D. Ginder, J. Neel Scarsdale, Jason M. Cramer, David C. Williams, Ninad M. Walavalkar
Publikováno v:
Journal of Biological Chemistry. 289:1294-1302
Although highly homologous to other methylcytosine-binding domain (MBD) proteins, MBD3 does not selectively bind methylated DNA, and thus the functional role of MBD3 remains in question. To explore the structural basis of its binding properties and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d87e761777d147b5ec21c163cd1bf2
https://doi.org/10.1074/jbc.m113.512236
https://doi.org/10.1074/jbc.m113.512236
Autor:
Stephanie M. Bilinovich, Darrell L. Peterson, Maria E. Teves, David C. Williams, Hong Liu, Ling Zhang, Ninad M. Walavalkar, William A. Buchwald, Wei Li, Zhibing Zhang, Jerome F. Strauss
Publikováno v:
Scientific Reports
The product of the meiosis-expressed gene 1 (MEIG1) is found in the cell bodies of spermatocytes and recruited to the manchette, a structure unique to elongating spermatids, by Parkin co-regulated gene (PACRG). This complex is essential for targeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b8f3bdfd3e4b1ebcac902b95af68057
Autor:
Leander M. Sinanan, Ninad M. Walavalkar, Megha Desai, David C. Williams, Gordon D. Ginder, Heather D. Webb, J. Neel Scarsdale
Publikováno v:
Nucleic Acids Research
The MBD2-NuRD (Nucleosome Remodeling and Deacetylase) complex is an epigenetic reader of DNA methylation that regulates genes involved in normal development and neoplastic diseases. To delineate the architecture and functional interactions of the MBD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f611e76c011e93d11ada63c9f1320b
https://pubmed.ncbi.nlm.nih.gov/25753662
https://pubmed.ncbi.nlm.nih.gov/25753662
Autor:
Stephen S. Rich, Mete Civelek, Ninad M. Walavalkar, Yunxian Liu, Mikhail G. Dozmorov, Michael J. Guertin
Publikováno v:
PLoS Genetics, Vol 13, Iss 9, p e1006761 (2017)
Genome-wide association studies (GWAS) have discovered thousands loci associated with disease risk and quantitative traits, yet most of the variants responsible for risk remain uncharacterized. The majority of GWAS-identified loci are enriched for no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dcffa4198b9c8815a6277bad5d7bdef
https://doi.org/10.1371/journal.pgen.1006761
https://doi.org/10.1371/journal.pgen.1006761
Publikováno v:
The Journal of biological chemistry. 288(5)
The methyl-cytosine binding domain 2 (MBD2)-nucleosome remodeling and deacetylase (NuRD) complex recognizes methylated DNA and silences expression of associated genes through histone deacetylase and nucleosome remodeling functions. Our previous struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe4991379fc45d0901cdc57b9f3825d
https://pubmed.ncbi.nlm.nih.gov/23239876
https://pubmed.ncbi.nlm.nih.gov/23239876