Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Nina Y. Yuan"'
Publikováno v:
Cells, Vol 11, Iss 13, p 2123 (2022)
Background: Combination antiretroviral therapy (cART) has transformed HIV infection from a terminal disease to a manageable chronic health condition, extending patients’ life expectancy to that of the general population. However, the incidence of H
Externí odkaz:
https://doaj.org/article/a3c6960dce754f2285ab155e96273b6a
Autor:
Nina Y Yuan, Marcus Kaul
Publikováno v:
J Neuroimmune Pharmacol
HIV-associated neurocognitive disorders (HAND) persist despite the successful introduction of combination antiretroviral therapy (cART). While insufficient concentration of certain antiretrovirals (ARV) may lead to incomplete viral suppression in the
Autor:
Michael M. Poe, James M. Cook, Douglas C. Stafford, Leggy A. Arnold, Amanda N. Nieman, Nicolas M Zahn, Michael Rajesh Stephen, Ted William Harris, Guanguan Li, Revathi Kodali, Gene T. Yocum, Rajwana Jahan, Charles W. Emala, Benjamin D. Hartzler, Olivia B. Yu, Margaret L. Guthrie, Nina Y. Yuan, Douglas A. Steeber, Gloria S. Forkuo
Publikováno v:
Molecular Pharmaceutics. 14:2088-2098
We describe pharmacokinetic and pharmacodynamic properties of two novel oral drug candidates for asthma. Phenolic α4β3γ2 GABAAR selective compound 1 and acidic α5β3γ2 selective GABAAR positive allosteric modulator compound 2 relaxed airway smoo
Autor:
Margaret L. Guthrie, Nicolas M Zahn, Douglas C. Stafford, Rajwana Jahan, Leggy A. Arnold, James M. Cook, Charles W. Emala, Revathi Kodali, Olivia B. Yu, Nina Y. Yuan, Guanguan Li, Michael Rajesh Stephen, Gloria S. Forkuo, Gene T. Yocum, Michael M. Poe, Amanda N. Nieman
Publikováno v:
European Journal of Medicinal Chemistry. 126:550-560
We describe the synthesis of analogs of XHE-III-74, a selective α4β3γ2 GABAAR ligand, shown to relax airway smooth muscle ex vivo and reduce airway hyperresponsiveness in a murine asthma model. To improve properties of this compound as an asthma t
Autor:
Michael M. Poe, Nina Y. Yuan, Christopher M. Witzigmann, Leggy A. Arnold, Douglas C. Stafford, James M. Cook
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 82:109-114
Introduction Automated patch clamp is a recent but widely used technology to assess pre-clinical drug safety. With the availability of human neurons derived from pluripotent stem cells, this technology can be extended to determine CNS effects of drug
Autor:
Michael M. Poe, Revathi Kodali, Gene T. Yocum, Margaret L. Guthrie, Marco Treven, Charles W. Emala, Benjamin D. Hartzler, Rajwana Jahan, Olivia B. Yu, Leggy A. Arnold, Guanguan Li, Michael Rajesh Stephen, James M. Cook, Nina Y. Yuan, Douglas C. Stafford, Gloria S. Forkuo, Nicolas M Zahn, Amanda N. Nieman, Margot Ernst
Publikováno v:
Molecular Pharmaceutics. 13:2026-2038
Recent studies have demonstrated that subtype-selective GABAA receptor modulators are able to relax precontracted human airway smooth muscle ex vivo and reduce airway hyper-responsiveness in mice upon aerosol administration. Our goal in this study wa
Autor:
Daniel D. Bikle, Belaynesh Feleke, Adam Yasgar, Ajit Jadhav, Anton Simeonov, Chinedum Kevin, Ganesha Rai, Preetpal S. Sidhu, Premchendar Nandhikonda, David G. Maloney, Nina Y. Yuan, Alan J. Pawlak, Athena M. Baranowski, Megan M. McCallum, Paul Webb, Stephen D. Ayers, Kelly A. Teske, Leggy A. Arnold
Publikováno v:
Biochemistry, vol 52, iss 24
A high-throughput screening campaign was conducted to identify small molecules with the ability to inhibit the interaction between the vitamin D receptor (VDR) and steroid receptor coactivator 2. These inhibitors represent novel molecular probes for
Autor:
Nina Y, Yuan, Michael M, Poe, Christopher, Witzigmann, James M, Cook, Douglas, Stafford, Leggy A, Arnold
Publikováno v:
Journal of pharmacological and toxicological methods. 82
Automated patch clamp is a recent but widely used technology to assess pre-clinical drug safety. With the availability of human neurons derived from pluripotent stem cells, this technology can be extended to determine CNS effects of drug candidates,
Autor:
Leggy A. Arnold, Dana Pearson, Wen Z. Lynt, Premchendar Nandhikonda, Daniel D. Bikle, Nina Y. Yuan, R. Kiplin Guy, Tahniyath Ara, Athena M. Baranowski, Megan M. McCallum
Publikováno v:
Journal of Medicinal Chemistry. 55:4640-4651
The vitamin D receptor (VDR) is a nuclear hormone receptor that regulates cell proliferation, cell differentiation, and calcium homeostasis. The receptor is activated by vitamin D analogues that induce the disruption of VDR-corepressor binding and pr
Autor:
Joshua Preston, Robin Goy, Jonathan W. Bogart, Preetpal S. Sidhu, James M. Cook, Belaynesh Feleke, Daniel D. Bikle, Rakesh K. Singh, Nina Y. Yuan, Nicholas R. Silvaggi, Kelly A. Teske, Leggy A. Arnold, Premchendar Nandhikonda, Lanlan Han
Publikováno v:
Nuclear Receptor Research, Vol 1, Pp 1-8 (2014)
Herein, we described the development of two virtual screens to identify new vitamin D receptor (VDR) antagonists among nuclear receptor (NR) ligands. Therefore, a database of 14330 nuclear receptor ligands and their NR affinities was assembled using