Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Nina V Fuchs"'
Autor:
Julia Fekadu-Siebald, Nina V Fuchs, Stella Zahn, Marcel G E Rommel, Franziska Schenk, Sabine Huenecke, Melanie Bremm, Hermann Kreyenberg, Zyrafete Kuci, Eva-Maria Jacobsen, Manfred Hoenig, Klaus Schwarz, Peter Bader, Ute Modlich, Renate König, Shahrzad Bakhtiar
Publikováno v:
Stem Cell Research, Vol 81, Iss , Pp 103598- (2024)
Leukocyte Adhesion Deficiency Type I (LAD I) is a rare inborn error of immunity caused by mutations in the ITGB2 gene coding for β2-integrin CD18 on the surface of leukocytes. Affected patients display severe clinical manifestations with life threat
Externí odkaz:
https://doaj.org/article/bd97289784814a2da913e1a94f44be78
Publikováno v:
Viruses, Vol 16, Iss 8, p 1340 (2024)
The intrinsically disordered polyglutamine-binding protein 1 (PQBP1) has been linked to various cellular processes including transcription, alternative splicing, translation and innate immunity. Mutations in PQBP1 are causative for neurodevelopmental
Externí odkaz:
https://doaj.org/article/1ae9d9e22ea94f8f912a6066b2ff12a5
Autor:
Chaohui Lin, Edmund Osei Kuffour, Nina V. Fuchs, Christoph G.W. Gertzen, Jesko Kaiser, Maximilian Hirschenberger, Xiao Tang, Haifeng C. Xu, Oliver Michel, Ronny Tao, Alexandra Haase, Ulrich Martin, Thomas Kurz, Ingo Drexler, Boris Görg, Philipp A. Lang, Tom Luedde, Konstantin M.J. Sparrer, Holger Gohlke, Renate König, Carsten Münk
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113277- (2023)
Summary: Sensing of human immunodeficiency virus type 1 (HIV-1) DNA is mediated by the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling axis. Signal transduction and regulation of this cascade is achieved by post-translat
Externí odkaz:
https://doaj.org/article/a3e194c999a94c19ad46494fc14d84d4
Autor:
Gerald G. Schumann, Nina V. Fuchs, Pablo Tristán-Ramos, Attila Sebe, Zoltán Ivics, Sara R. Heras
Publikováno v:
Mobile DNA, Vol 10, Iss 1, Pp 1-23 (2019)
Abstract Human stem cells harbor significant potential for basic and clinical translational research as well as regenerative medicine. Currently ~ 3000 adult and ~ 30 pluripotent stem cell-based, interventional clinical trials are ongoing worldwide,
Externí odkaz:
https://doaj.org/article/754709407bfe48578aa76e7b6d842beb
Autor:
Júlia Canet-Pons, Nesli-Ece Sen, Aleksandar Arsović, Luis-Enrique Almaguer-Mederos, Melanie V. Halbach, Jana Key, Claudia Döring, Anja Kerksiek, Gina Picchiarelli, Raphaelle Cassel, Frédérique René, Stéphane Dieterlé, Nina V. Fuchs, Renate König, Luc Dupuis, Dieter Lütjohann, Suzana Gispert, Georg Auburger
Publikováno v:
Neurobiology of Disease, Vol 152, Iss , Pp 105289- (2021)
Large polyglutamine expansions in Ataxin-2 (ATXN2) cause multi-system nervous atrophy in Spinocerebellar Ataxia type 2 (SCA2). Intermediate size expansions carry a risk for selective motor neuron degeneration, known as Amyotrophic Lateral Sclerosis (
Externí odkaz:
https://doaj.org/article/52a024677ac64e5d9a2e23fc61696b54
Autor:
Nina V. Fuchs, Maximilian Schieck, Michaela Neuenkirch, Christiane Tondera, Heike Schmitz, Lena Wendeburg, Doris Steinemann, Christiane Elpers, Frank Rutsch, Renate König
Publikováno v:
Stem Cell Research, Vol 43, Iss , Pp - (2020)
Aicardi-Goutières syndrome (AGS) is a hereditary early onset encephalopathy. AGS patients display variable clinical manifestations including intracranial calcification, cerebral atrophy, white matter abnormalities and characteristic leukocytosis as
Externí odkaz:
https://doaj.org/article/045c20fd937f4828a9c70550046d4de4
Autor:
Nina V. Fuchs, Maximilian Schieck, Michaela Neuenkirch, Christiane Tondera, Heike Schmitz, Doris Steinemann, Gudrun Göhring, Renate König
Publikováno v:
Stem Cell Research, Vol 42, Iss , Pp - (2020)
Induced pluripotent stem cells (iPSCs) are a useful tool to investigate pathomechanistic and cellular processes due to their differentiation potential into different somatic cell types in vitro. Here, we have generated iPSCs from an apparently health
Externí odkaz:
https://doaj.org/article/1a60c09a227a4d4798d9a05bddcecc2c
Autor:
Kerstin Schott, Nina V. Fuchs, Rita Derua, Bijan Mahboubi, Esther Schnellbächer, Janna Seifried, Christiane Tondera, Heike Schmitz, Caitlin Shepard, Alberto Brandariz-Nuñez, Felipe Diaz-Griffero, Andreas Reuter, Baek Kim, Veerle Janssens, Renate König
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
SAMHD1 is a critical restriction factor for HIV-1 and its antiviral activity is regulated by T592 phosphorylation. Here, Schott et al. show that the phosphatase PP2A-B55α dephosphorylates SAMHD1 during mitotic exit, rendering it antivirally active i
Externí odkaz:
https://doaj.org/article/3b8f796c4d5d4e31b78e854d8aab59b2
Autor:
Nina V. Fuchs, Maximilian Schieck, Michaela Neuenkirch, Christiane Tondera, Heike Schmitz, Vincent des Portes, David Germanaud, Doris Steinemann, Gudrun Göhring, Renate König
Publikováno v:
Stem Cell Research, Vol 41, Iss , Pp - (2019)
The Renpenning syndrome spectrum is a rare X-linked mental retardation syndrome characterized by intellectual disability, microcephaly, low stature, lean body and hypogonadism. Mutations in the polyglutamine tract binding protein 1 (PQBP1) locus are
Externí odkaz:
https://doaj.org/article/357b2ee2ab3e46e3991df1b14c7876f6
Autor:
Sabine Klawitter, Nina V. Fuchs, Kyle R. Upton, Martin Muñoz-Lopez, Ruchi Shukla, Jichang Wang, Marta Garcia-Cañadas, Cesar Lopez-Ruiz, Daniel J. Gerhardt, Attila Sebe, Ivana Grabundzija, Sylvia Merkert, Patricia Gerdes, J. Andres Pulgarin, Anja Bock, Ulrike Held, Anett Witthuhn, Alexandra Haase, Balázs Sarkadi, Johannes Löwer, Ernst J. Wolvetang, Ulrich Martin, Zoltán Ivics, Zsuzsanna Izsvák, Jose L. Garcia-Perez, Geoffrey J. Faulkner, Gerald G. Schumann
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Genetic and epigenetic abnormalities have been found to result from reprogramming of differentiated cells into human induced pluripotent stem cells (hiPSCs). Here, Klawitter et al.identify endogenous L1, Alu and SVA mobilization during reprogramming,
Externí odkaz:
https://doaj.org/article/c3ef18eb5c21445d985ad18b9ff23d87