Autophagy Drives Galectin-1 Secretion From Tumor-Associated Macrophages Facilitating Hepatocellular Carcinoma Progression

Autor: Goutham Venkata Naga Davuluri, Chien-Chin Chen, Yen-Cheng Chiu, Hung-Wen Tsai, Hung-Chih Chiu, Yuh-Ling Chen, Pei-Jane Tsai, Wan-Ting Kuo, Nina Tsao, Yee-Shin Lin, Chih-Peng Chang

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Galectin-1 (Gal-1) is a secretory lectin with pro-tumor activities and is associated strongly with hepatocellular carcinoma (HCC) development. Although Gal-1 is a well-known soluble pro-tumor factor in the tumor microenvironment (TME), the secretion

Externí odkaz: https://doaj.org/article/f024fb2936b9484f9b025b7b4d48754c

Application of the C3-binding motif of streptococcal pyrogenic exotoxin B to protect mice from invasive group a streptococcal infection.

Autor: Chih-Feng Kuo, Nina Tsao, Miao-Hui Cheng, Hsiu-Chen Yang, Yu-Chieh Wang, Ying-Pin Chen, Kai-Jen Lin

Publikováno v: PLoS ONE, Vol 10, Iss 1, p e0117268 (2015)

Group A streptococcus (GAS) is an important human pathogen that produces several extracellular exotoxins to facilitate invasion and infection. Streptococcal pyrogenic exotoxin B (SPE B) has been demonstrated to be an important virulence factor of GAS

Externí odkaz: https://doaj.org/article/bb95efa1c077499d8e9055c1dba0a86f

IL-33/ST2 Axis Plays a Protective Effect in Streptococcus pyogenes Infection through Strengthening of the Innate Immunity

Autor: Yu-Hsuan Tsai, Wei-Yu Chen, Chih-Feng Kuo, Ya-Chu Chang, Nina Tsao, Chih Peng Chang, Hai-Han Yu

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 10566, p 10566 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 19

Group A Streptococcus (GAS) causes invasive human diseases with the cytokine storm. Interleukin-33 (IL-33)/suppression of tumorigenicity 2 (ST2) axis is known to drive TH2 response, while its effect on GAS infection is unclear. We used an air pouch m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66bea046e4b2a93f401776f16f3c3875
https://www.mdpi.com/1422-0067/22/19/10566

Streptolysin S induces mitochondrial damage and macrophage death through inhibiting degradation of glycogen synthase kinase-3β in Streptococcus pyogenes infection

Autor: Chih Feng Kuo, Wei-Chen Lin, Yee Shin Lin, Nina Tsao, Miao Hui Cheng, Chiou Feng Lin

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)

Group A Streptococcus (GAS) infection is associated with a variety of human diseases. Previous studies indicate GAS infection leads to RAW264.7 cell death, but the mechanism is unclear. Here, analyzing the timing of reactive oxygen species (ROS) prod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ddd1385a86a272af863b0902b1a1eb
http://europepmc.org/articles/PMC6440947

Development of hematogenous pneumococcal meningitis in adult mice: the role of TNF-α

Autor: Ching Chuan Liu, W. W. Chang, Huan Yao Lei, Nina Tsao

Publikováno v: FEMS Immunology & Medical Microbiology. 32:133-140

Bacterial penetration across the blood-brain barrier (BBB) into the central nervous system is the first step in development of meningitis. The role of tumor necrosis factor-alpha (TNF-alpha) in the penetration process was examined with peripheral inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddcf8c1ffd92b6b03e9256c52128c6ad
https://doi.org/10.1111/j.1574-695x.2002.tb00545.x