Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Nina Tonnu"'
Autologous and Heterologous Cell Therapy for Hemophilia B toward Functional Restoration of Factor IX
Autor:
Suvasini Ramaswamy, Nina Tonnu, Tushar Menon, Benjamin M. Lewis, Kevin T. Green, Derek Wampler, Paul E. Monahan, Inder M. Verma
Publikováno v:
Cell Reports, Vol 23, Iss 5, Pp 1565-1580 (2018)
Summary: Hemophilia B is an ideal target for gene- and cell-based therapies because of its monogenic nature and broad therapeutic index. Here, we demonstrate the use of cell therapy as a potential long-term cure for hemophilia B in our FIX-deficient
Externí odkaz:
https://doaj.org/article/99d1db73e32248199a75fdbc19416971
Autor:
Ryoko Ando, Junko Ogawa, Yoko Iwata, Sachihiko Itoh, Ling Huang, Inder M. Verma, Atsushi Miyawaki, Chitra Gopinath, Gerald M. Pao, Nina Tonnu
The optical refractive index of cellular components is generally not a property considered amenable to manipulation in microscopy as this is an intrinsic physical property of materials. Here we show that by targeting cephalopod reflectin protein nano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::954a9d63d80707d4e4fdafe4c5017af3
https://doi.org/10.1101/2020.07.09.196436
https://doi.org/10.1101/2020.07.09.196436
Autologous and Heterologous Cell Therapy for Hemophilia B toward Functional Restoration of Factor IX
Autor:
Benjamin M. Lewis, Tushar Menon, Paul E. Monahan, Suvasini Ramaswamy, Nina Tonnu, Kevin Green, Derek Wampler, Inder M. Verma
Publikováno v:
Cell Reports, Vol 23, Iss 5, Pp 1565-1580 (2018)
Cell reports
Cell reports
SUMMARY Hemophilia B is an ideal target for gene- and cell-based therapies because of its monogenic nature and broad therapeutic index. Here, we demonstrate the use of cell therapy as a potential long-term cure for hemophilia B in our FIX-deficient m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f888da2642cf67e6e1e7d50979ad190
http://www.sciencedirect.com/science/article/pii/S2211124718304972
http://www.sciencedirect.com/science/article/pii/S2211124718304972
Autor:
Nina Tonnu, Jerel Vega, Suvasini Ramaswamy, Pad Chivukula, Pattraranee Limphong, Inder M. Verma, Priya Prakash Karmali, Kiyoshi Tachikawa
Safe and efficient delivery of messenger RNAs for protein replacement therapies offers great promise but remains challenging. In this report, we demonstrate systemic, in vivo, nonviral mRNA delivery through lipid nanoparticles (LNPs) to treat a Facto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a17ed3c56a491c15761d82d432f232fd
https://europepmc.org/articles/PMC5347596/
https://europepmc.org/articles/PMC5347596/
Autor:
Zhongsheng You, Quan Zhu, Linda Z. Shi, Andrew Basilio, Peng Wu, Tony Hunter, Nina Tonnu, Youwei Zhang, Inder M. Verma, Michael W. Berns
Publikováno v:
Molecular Cell. 36:954-969
In response to DNA double-strand breaks (DSBs), cells sense the DNA lesions and then activate the protein kinase ATM. Subsequent DSB resection produces RPA-coated ssDNA that is essential for activation of the DNA damage checkpoint and DNA repair by h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347898f781530b2a78527cbb2f3dfb26
https://doi.org/10.1016/j.molcel.2009.12.002
https://doi.org/10.1016/j.molcel.2009.12.002
Autor:
Inder M. Verma, Hoonkyo Suh, Nina Tonnu, Petra M. Nederlof, Fred H. Gage, Alexis M. Huynh, Gerald M. Pao, Quan Zhu
Publikováno v:
Nature
Mutations in the tumour suppressor gene BRCA1 lead to breast and/or ovarian cancer. Here we show that loss of Brca1 in mice results in transcriptional de-repression of the tandemly repeated satellite DNA. Brca1 deficiency is accompanied by a reductio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0609fed91f355603251c6576fb1083c4
https://pubmed.ncbi.nlm.nih.gov/21956483
https://pubmed.ncbi.nlm.nih.gov/21956483
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 100(3), 1298-1303. National Academy of Sciences
HIV-1 replication in simian cells is restricted at an early postentry step because of the presence of an inhibitory cellular factor. This block reduces the usefulness of HIV-1-based lentiviral vectors in primate animal models. Here, we demonstrate th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9ba8f4d8ca98f2754a715fe19b81797
https://pubmed.ncbi.nlm.nih.gov/12547912
https://pubmed.ncbi.nlm.nih.gov/12547912
Publikováno v:
Cancer Research. 68:LB-330
Introduction: BRCA1, as well as BRCA2, were identified as the hereditary breast and ovarian cancer susceptibility genes that can account for almost all of inherited cases of breast cancers. BRCA1 is a multifunctional nuclear protein with a RING domai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c302aded5c1733a19253a45dd24a37fd
https://doi.org/10.1158/1538-7445.am2008-lb-330
https://doi.org/10.1158/1538-7445.am2008-lb-330