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Akademický článek

Epithelial Dual Oxidase 2 Shapes the Mucosal Microbiome and Contributes to Inflammatory Susceptibility

Autor: Juan Camilo Castrillón-Betancur, Víctor Alonso López-Agudelo, Nina Sommer, Sven Cleeves, Joana Pimenta Bernardes, Saskia Weber-Stiehl, Philip Rosenstiel, Felix Sommer

Publikováno v: Antioxidants, Vol 12, Iss 10, p 1889 (2023)

Reactive oxygen species (ROS) are highly reactive molecules formed from diatomic oxygen. They act as cellular signals, exert antibiotic activity towards invading microorganisms, but can also damage host cells. Dual oxidase 2 (DUOX2) is the main ROS-p

Externí odkaz: https://doaj.org/article/65adb601ceef40f79fd950d301d7502b

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Phone use while parenting: An observational study to assess the association of maternal sensitivity and smartphone use in a playground setting

Autor: Sophie Kitzmann, Lara N. Wolfers, Sabine Sauer, Nina Sommer

Publikováno v: Computers in Human Behavior. 102:31-38

Smartphone use has become an “always-on” activity. Caring for children and being sensitive to their needs seems to conflict with this immersive and time-consuming activity. Building on John Bowlby's Attachment Theory, we focused on how mothers' s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e3aa4964661d10b807b71b2ebe0670c5
https://doi.org/10.1016/j.chb.2019.08.013

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Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis

Publikováno v: Cell Metab. 33, 2355-2366.e8 (2021)
Hinrichsen, F, Hamm, J, Westermann, M, Schröder, L, Shima, K, Mishra, N, Walker, A, Sommer, N, Klischies, K, Prasse, D, Zimmermann, J, Kaiser, S, Bordoni, D, Fazio, A, Marinos, G, Laue, G, Imm, S, Tremaroli, V, Basic, M, Häsler, R, Schmitz, R A, Krautwald, S, Wolf, A, Stecher, B, Schmitt-Kopplin, P, Kaleta, C, Rupp, J, Bäckhed, F, Rosenstiel, P & Sommer, F 2021, ' Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis ', Cell Metabolism, vol. 33, no. 12, pp. 2355-2366.e8 . https://doi.org/10.1016/j.cmet.2021.11.004

Hexokinases (HK) catalyze the first step of glycolysis limiting its pace. HK2 is highly expressed in gut epithelium, contributes to immune responses, and is upregulated during inflammation. We examined the microbial regulation of HK2 and its impact o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71ff874f57137415da69016c677d9213
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=63735

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Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis

SummaryHexokinases (HK) catalyze the first step of glycolysis and thereby limit its pace. HK2 is highly expressed in the gut epithelium, plays a role in immune responses and is upregulated in inflammation and ulcerative colitis 1–3. Here, we examin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c845abb2e4b39c598e8e2ce114d4b5f
https://doi.org/10.1101/2020.12.22.423953

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Mikrobielle Regulation von Hexokinase 2 koordiniert mitochondrialen Metabolismus und Zelltod bei akuter Colitis

Autor: Kenneth Klischies, Bärbel Stecher, Valentina Tremaroli, Nina Sommer, Fredrik Bäckhed, M Basic, Daniela Prasse, Lena Schröder, P Rosenstiel, Kensuke Shima, R Schmitz-Streit, Jacob Hamm, Jan Rupp, Felix Sommer, Neha Mishra, Robert Häsler, Finn Hinrichsen

Publikováno v: DGVS Digital: BEST OF DGVS.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90b2c451d0006f6973867015404db65c
https://doi.org/10.1055/s-0040-1716123

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Regulated proteolysis as an element of ER stress and autophagy: Implications for intestinal inflammation

Autor: Nina Sommer, Stephanie T. Stengel, Philip Rosenstiel, Berith Messner, Maren Falk-Paulsen

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1864:2183-2190

Endoplasmic reticulum (ER) stress and autophagy are tightly controlled cellular processes, which are responsible for maintaining protein homeostasis in a cell. Impairment of the interlinking pathways have been implicated in a number of human diseases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d38ff92d20d8b25cddce433e0daf0bf
https://doi.org/10.1016/j.bbamcr.2017.07.008

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Specific synbiotics in early life protect against diet-induced obesity in adult mice

Autor: Jan Knol, Fredrik Bäckhed, Tulika Arora, Eefje Engels, Kees van Limpt, Nina Sommer, Annemarie Oosting, Sebastian Tims, Mona Mischke, Annemarie M. Baars, Raish Oozeer

Publikováno v: Diabetes, Obesity & Metabolism
Diabetes, Obesity and Metabolism, 20(6), 1408-1418
Mischke, M, Arora, T, Tims, S, Engels, E, Sommer, N, van Limpt, K, Baars, A, Oozeer, R, Oosting, A, Bäckhed, F & Knol, J 2018, ' Specific synbiotics in early life protect against diet-induced obesity in adult mice ', Diabetes, Obesity and Metabolism, vol. 20, no. 6, pp. 1408-1418 . https://doi.org/10.1111/dom.13240
Diabetes, Obesity and Metabolism 20 (2018) 6

AIMS: The metabolic state of human adults is associated with their gut microbiome. The symbiosis between host and microbiome is initiated at birth, and early life microbiome perturbation can disturb health long-lastingly. Here, we determined how bene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::382d2d9d62d56bbebea96d0724e51ac1
https://pubmed.ncbi.nlm.nih.gov/29460474

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