Zobrazeno 1 - 9
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pro vyhledávání: '"Nina Sheung"'
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 303:G904-G914
Adenosine is a potent modulator of liver fibrosis and inflammation. Adenosine has been shown to regulate such diverse activities as chemotaxis, contraction, and matrix production in hepatic stellate cells (HSC). Ecto-5′-nucleotidase/CD73 [EC 3.1.3.
Autor:
Jonathan A. Dranoff, Jean Sévigny, Nina Sheung, Julie Pelletier, Elwy M. Soliman, Gilles Kauffenstein, Michel Fausther, Joanna Lecka
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 302:G447-G459
Ectonucleotidases modulate purinergic signaling by hydrolyzing ATP to adenosine. Here we characterized the impact of the cellular distribution of hepatic ectonucleotidases, namely nucleoside triphosphate diphosphohydrolase (NTPDase)1/CD39, NTPDase2/C
Autor:
Dawidson Assis Gomes, Jin Yu, Jonathan A. Dranoff, Michele Angela Rodrigues, Michael H. Nathanson, Maria Jimina Amaya, Elwy M. Soliman, Nina Sheung
Publikováno v:
Cell Calcium. 45:284-292
Hepatic stellate cells (HSC) are important mediators of liver fibrosis. Hormones linked to downstream intracellular Ca(2+) signals upregulate HSC proliferation, but the mechanisms by which this occurs are unknown. Nuclear and cytosolic Ca(2+) signals
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 294:G748-G756
Bile ductular proliferation is markedly upregulated in biliary fibrosis and cirrhosis. However, the mechanisms regulating this upregulation in bile ductular proliferation have not been defined. Recently, we demonstrated that expression of the ectonuc
Autor:
Giulia Baldini, Nina Sheung, Neal K. Bhatia, DaShawn A. Hickman, Jonathan A. Dranoff, Susana Granell, Michel Fausther, Elise G. Lavoie
Publikováno v:
Physiological Reports
Liver myofibroblasts derived from hepatic stellate cells (HSC) are critical mediators of liver fibrosis. Release of tissue inhibitor of metalloproteinase-1 (TIMP-1) advances liver fibrosis by blocking fibrinolysis. The mechanisms responsible for the
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 296(3)
The inflammatory cytokine IL-6 is essential for cell survival after liver injury. Bile duct epithelia (BDE) markedly upregulate IL-6 release after liver injury, but the mechanisms regulating this have not been defined. Purinergic signals induce multi
Publikováno v:
Gastroenterology. 140:S-981
Publikováno v:
American Journal of Physiology: Gastrointestinal & Liver Physiology; Oct2012 Part2, Vol. 303 Issue 4, pG904-G914, 11p
Publikováno v:
American Journal of Physiology: Gastrointestinal & Liver Physiology; Mar2009, Vol. 296, pG563-G571, 9p, 1 Chart, 10 Graphs