Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Nina Schömel"'
Autor:
Marthe-Susanna Wegner, Lisa Gruber, Nina Schömel, Ellen M. Olzomer, Kyle L. Hoehn, Stephanie J. Alexopoulos, Nerea Ferreirós, Robert Gurke, Gerd Geisslinger, Frances L. Byrne, Sandra Trautmann, Dominique Thomas
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
The only enzyme in the glycosphingolipid (GSL) metabolic pathway, which produces glucosylceramide (GlcCer) de novo is UDP-glucose ceramide glucosyltransferase (UGCG). UGCG is linked to pro-cancerous processes such as multidrug resistance development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aca4fc4589d9dee71b1a92019ee23d7c
http://link.springer.com/article/10.1038/s41598-020-65182-y
http://link.springer.com/article/10.1038/s41598-020-65182-y
Autor:
Bernhard Brüne, Catherine Olesch, Sandra Trautmann, Nerea Ferreirós, Frances L. Byrne, Nina Schömel, Kyle L. Hoehn, Ellen M. Olzomer, Gerd Geisslinger, Andreas Weigert, Marthe-Susanna Wegner, Robert Gurke
Publikováno v:
Cellular and Molecular Life Sciences
Hepatocellular carcinoma (HCC) is one of the most difficult cancer types to treat. Liver cancer is often diagnosed at late stages and therapeutic treatment is frequently accompanied by development of multidrug resistance. This leads to poor outcomes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31bb2231a02d728248e31134a2cabc1c
https://publica.fraunhofer.de/handle/publica/415440
https://publica.fraunhofer.de/handle/publica/415440
Publikováno v:
Progress in lipid research. 79
A growing number of studies describe a connection between glycosphingolipids (GSLs) and glutamine metabolism, glucose metabolism and mitochondrial dysfunction in cancer cells. Since deregulated cell energy metabolism is one of cancer cells hallmarks,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a432e511e1fa9df8ef235eb52e9d1b
https://pubmed.ncbi.nlm.nih.gov/32592726
https://pubmed.ncbi.nlm.nih.gov/32592726
Autor:
Sabine Grösch, Bing Peng, Peter Mattjus, Gerd Geisslinger, Lisa Gruber, Sandra Trautmann, Marthe-Susanna Wegner, Martin Wegner, Matti A. Kjellberg, Manuel Kaulich, Stephanie Beatrice Örtel, Jennifer Kurz, Robert Ahrends, Nina Schömel
Publikováno v:
Cellular and Molecular Life Sciences. 75:3393-3410
The UDP-glucose ceramide glucosyltransferase (UGCG) is a key enzyme in the synthesis of glycosylated sphingolipids, since this enzyme generates the precursor for all complex glycosphingolipids (GSL), the GlcCer. The UGCG has been associated with seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa2cb134c7c928dc9215d2e2dfd2fa4a
https://doi.org/10.1007/s00018-018-2799-7
https://doi.org/10.1007/s00018-018-2799-7
Autor:
Marthe-Susanna Wegner, Ellen M. Olzomer, Nina Schömel, Sabine Grösch, Lisa Gruber, Gerd Geisslinger, Frances L. Byrne, Divya P. Shah, Nigel Turner, Sarah E. Hancock, Kyle L. Hoehn
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports
UDP-glucose ceramide glucosyltransferase (UGCG) is the key enzyme in glycosphingolipid (GSL) metabolism by being the only enzyme that generates glucosylceramide (GlcCer) de novo. Increased UGCG synthesis is associated with pro-cancerous processes suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d3e32d25c6c4bb3c7f664e2f8a270a
https://doi.org/10.1038/s41598-019-52169-7
https://doi.org/10.1038/s41598-019-52169-7
Autor:
Sebastian Brachtendorf, Sabine Grösch, Gerd Geisslinger, Yannick Schreiber, Marthe-Susanna Wegner, Sandra Trautmann, Catherine Olesch, Lisa Gruber, Dominik C. Fuhrmann, Bernhard Brüne, Nina Schömel
Publikováno v:
The international journal of biochemistrycell biology. 112
The G protein-coupled estrogen receptor 1 (GPER1) is involved in the regulation of physiological processes such as cellular growth and proliferation, but also in pathophysiological processes such as tumor development. The role of GPER1 in breast canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3cd9b99cc8fd57527493f48f92e7156
https://pubmed.ncbi.nlm.nih.gov/31082617
https://pubmed.ncbi.nlm.nih.gov/31082617
Autor:
Peter Mattjus, Lisa Gruber, Nerea Ferreirós, Marthe-Susanna Wegner, Gerd Geisslinger, Nina Schömel, Lisa Hahnefeld, Caroline Fischer, Robert Gurke, Martina Beretta
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 127:105834
Identifying co-expression of lipid species is challenging, but indispensable to identify novel therapeutic targets for breast cancer treatment. Lipid metabolism is often dysregulated in cancer cells, and changes in lipid metabolism affect cellular pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5394bdc40838f924b126a9f79bb054a6
https://doi.org/10.1016/j.biocel.2020.105834
https://doi.org/10.1016/j.biocel.2020.105834
Autor:
Gerhild van Echten-Deckert, Ralf Frederik Claas, Agnes Rudowski, Dieter Lütjohann, Nathalie Mabrouki, Nina Schömel, Dagmar Meyer zu Heringdorf, Josef Pfeilschifter, Hans Vienken, Katja Grabau
Publikováno v:
Scientific Reports
Sphingosine-1-phosphate (S1P) lyase irreversibly cleaves S1P, thereby catalysing the ultimate step of sphingolipid degradation. We show here that embryonic fibroblasts from S1P lyase-deficient mice (Sgpl1−/−-MEFs), in which S1P and sphingosine ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aedcb251ada430b8a6fcb46a3852d11
https://doi.org/10.1038/srep43575
https://doi.org/10.1038/srep43575
Autor:
Hans Vienken, Nathalie Mabrouki, Katja Grabau, Ralf Frederik Claas, Agnes Rudowski, Nina Schömel, Josef Pfeilschifter, Dieter Lütjohann, Gerhild van Echten-Deckert, Dagmar Meyer zu Heringdorf
Publikováno v:
Scientific Reports.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=issn20452322::0ab2fc38e567e1d1b796730d9d7a94fe