Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Nina Sausgruber"'
Autor:
Jeanette Marjorie Wood, Joy Zhu, Kantharaj Ethirajulu, Han-Chong Toh, Boon-Cher Goh, Wei-Peng Yong, Hannes Hentze, Ramesh Jayaraman, Mohammed Khalid Pasha, Yung Kiang Loh, Nina Sausgruber, Veronica Novotny-Diermayr
SB939 is an oral histone deacetylase (HDAC) inhibitor currently in phase II clinical trials potently inhibiting class I, II, and IV HDACs with favorable pharmacokinetic properties, resulting in tumor tissue accumulation. To show target efficacy, a We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a33fd5835618140d404352e513debfa
https://doi.org/10.1158/1535-7163.c.6535455
https://doi.org/10.1158/1535-7163.c.6535455
Autor:
Jeanette Marjorie Wood, Joy Zhu, Kantharaj Ethirajulu, Han-Chong Toh, Boon-Cher Goh, Wei-Peng Yong, Hannes Hentze, Ramesh Jayaraman, Mohammed Khalid Pasha, Yung Kiang Loh, Nina Sausgruber, Veronica Novotny-Diermayr
Supplementary Methods, Figures 1-2, Tables 1-2 from Pharmacodynamic Evaluation of the Target Efficacy of SB939, an Oral HDAC Inhibitor with Selectivity for Tumor Tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c67afc5b454d6b303b05ea9c843a6757
https://doi.org/10.1158/1535-7163.22496979
https://doi.org/10.1158/1535-7163.22496979
Autor:
Jeanette Marjorie Wood, Kantharaj Ethirajulu, Haishan Wang, Stefan Hart, Hannes Hentze, Kee Chuan Goh, Zahid Bonday, Yung Kiang Loh, Ai Leng Liang, Sven Pettersson, Gediminas Greicius, Pauline Yeo, Nina Sausgruber, Xiaofeng Wu, Chang Yong Hu, Kanda Sangthongpitag, Veronica Novotny-Diermayr
Supplementary Figures and Materials and Metholds from SB939, a Novel Potent and Orally Active Histone Deacetylase Inhibitor with High Tumor Exposure and Efficacy in Mouse Models of Colorectal Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b51e86e9b7513857bdd252443925fa
https://doi.org/10.1158/1535-7163.22485351.v1
https://doi.org/10.1158/1535-7163.22485351.v1
Autor:
Jeanette Marjorie Wood, Kantharaj Ethirajulu, Haishan Wang, Stefan Hart, Hannes Hentze, Kee Chuan Goh, Zahid Bonday, Yung Kiang Loh, Ai Leng Liang, Sven Pettersson, Gediminas Greicius, Pauline Yeo, Nina Sausgruber, Xiaofeng Wu, Chang Yong Hu, Kanda Sangthongpitag, Veronica Novotny-Diermayr
Supplementary Table 2 from SB939, a Novel Potent and Orally Active Histone Deacetylase Inhibitor with High Tumor Exposure and Efficacy in Mouse Models of Colorectal Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45515ad58f3fa654f42c307ee91c362b
https://doi.org/10.1158/1535-7163.22485345
https://doi.org/10.1158/1535-7163.22485345
Autor:
Jeanette Marjorie Wood, Kantharaj Ethirajulu, Haishan Wang, Stefan Hart, Hannes Hentze, Kee Chuan Goh, Zahid Bonday, Yung Kiang Loh, Ai Leng Liang, Sven Pettersson, Gediminas Greicius, Pauline Yeo, Nina Sausgruber, Xiaofeng Wu, Chang Yong Hu, Kanda Sangthongpitag, Veronica Novotny-Diermayr
Supplementary Table 1 from SB939, a Novel Potent and Orally Active Histone Deacetylase Inhibitor with High Tumor Exposure and Efficacy in Mouse Models of Colorectal Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea26232b2120ba418d9671855d8e245c
https://doi.org/10.1158/1535-7163.22485348.v1
https://doi.org/10.1158/1535-7163.22485348.v1
Autor:
Jeanette Marjorie Wood, Kantharaj Ethirajulu, Haishan Wang, Stefan Hart, Hannes Hentze, Kee Chuan Goh, Zahid Bonday, Yung Kiang Loh, Ai Leng Liang, Sven Pettersson, Gediminas Greicius, Pauline Yeo, Nina Sausgruber, Xiaofeng Wu, Chang Yong Hu, Kanda Sangthongpitag, Veronica Novotny-Diermayr
Supplementary Table 3 from SB939, a Novel Potent and Orally Active Histone Deacetylase Inhibitor with High Tumor Exposure and Efficacy in Mouse Models of Colorectal Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab078191ad592debcca47d0ad3279d38
https://doi.org/10.1158/1535-7163.22485342.v1
https://doi.org/10.1158/1535-7163.22485342.v1
Autor:
Jeanette Marjorie Wood, Kantharaj Ethirajulu, Haishan Wang, Stefan Hart, Hannes Hentze, Kee Chuan Goh, Zahid Bonday, Yung Kiang Loh, Ai Leng Liang, Sven Pettersson, Gediminas Greicius, Pauline Yeo, Nina Sausgruber, Xiaofeng Wu, Chang Yong Hu, Kanda Sangthongpitag, Veronica Novotny-Diermayr
Although clinical responses in liquid tumors and certain lymphomas have been reported, the clinical efficacy of histone deacetylase inhibitors in solid tumors has been limited. This may be in part due to the poor pharmacokinetic of these drugs, resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bfd470f6ae571ff56fa8b9560145061
https://doi.org/10.1158/1535-7163.c.6531900
https://doi.org/10.1158/1535-7163.c.6531900
Autor:
Mohamed Bentires-Alj, Debora Bonenfant, Hans Voshol, Sophie Sarret, Stephan Duss, Nicola Aceto, Nina Sausgruber, Abdullah Alajati
PDF file, 104K, List of peptides differentially phosphorylated in MCF10A-Delta-HER2 cells compared to WT-HER2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::709ddb447a8799bd5591f6df567344a2
https://doi.org/10.1158/0008-5472.22397700.v1
https://doi.org/10.1158/0008-5472.22397700.v1
Autor:
Mohamed Bentires-Alj, Debora Bonenfant, Hans Voshol, Sophie Sarret, Stephan Duss, Nicola Aceto, Nina Sausgruber, Abdullah Alajati
PDF file, 246K, Quantification of WT-HER2 or Delta-HER2 and their effect on wound healing (S1); Low level expression of Delta-HER2 induces P-ERK and P-AKT, increases migration and induces mammary tumors (S2); Effect of WT-HER2 and Delta-HER2 expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e9e762a05dca7d1a9fe2eae5c2f2a30
https://doi.org/10.1158/0008-5472.22397703.v1
https://doi.org/10.1158/0008-5472.22397703.v1
Autor:
Mohamed Bentires-Alj, Debora Bonenfant, Hans Voshol, Sophie Sarret, Stephan Duss, Nicola Aceto, Nina Sausgruber, Abdullah Alajati
PDF file, 66K, WT-HER2 or Delta-HER2 revealed a specific set of genes that were upregulated in MCF10A-Delta-HER2 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a96d52d0c84e67f96f56bc81fbe1fa09
https://doi.org/10.1158/0008-5472.22397697
https://doi.org/10.1158/0008-5472.22397697