Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nina Rosenqvist"'
Publikováno v:
Cell Transplantation, Vol 14 (2005)
The use of ex vivo gene therapy in the central nervous system has so far suffered from transgene downregulation. Condensation of the transgenic sequences has been proposed to be a mechanism involved in this silencing. In this study we inhibited eithe
Externí odkaz:
https://doaj.org/article/d589f943154d422d90e14576b31b6c51
Autor:
Anne-Marie Jacobsen, Nico C. van de Merbel, Dorte K. Ditlevsen, Ketil Tvermosegaard, Frank Schalk, Wietske Lambert, Christoffer Bundgaard, Jan T. Pedersen, Nina Rosenqvist
Publikováno v:
Journal of the American Society for Mass Spectrometry. 34:441-451
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::704601712633ffcd09e93dae917f910d
https://doi.org/10.1021/jasms.2c00324
https://doi.org/10.1021/jasms.2c00324
Autor:
Lone Helboe, Nina Rosenqvist, Christiane Volbracht, Lars Ø. Pedersen, Jan T. Pedersen, Søren Christensen, Jan Egebjerg, Claus T. Christoffersen, Benny Bang-Andersen, Thomas G. Beach, Geidy E. Serrano, Jeppe Falsig
Publikováno v:
Journal of Alzheimer's Disease. 88:207-228
Background: Deposits of hyperphosphorylated tau fibrils are hallmarks of a broad spectrum of tauopathies, including Alzheimer’s disease (AD). Objective: To investigate heterogeneity of tau pathology across brain extracts from a broad selection of d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90b02055038581d809760d2e5e312230
https://doi.org/10.3233/jad-220125
https://doi.org/10.3233/jad-220125
Publikováno v:
Journal of Neuroscience Research. 84:58-67
In this study we have developed and validated a novel approach of transgene regulation in the brain. By using lentiviral vectors that incorporate promoters of genes that are up-regulated during different pathological states, we were able to regulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50da7839338422018c94bf813f2b8631
https://doi.org/10.1002/jnr.20872
https://doi.org/10.1002/jnr.20872
Autor:
Christofer Samuelsson, Nina Rosenqvist, Jens Johansen, Caroline Hård af Segerstad, Cecilia Lundberg
Publikováno v:
The Journal of Gene Medicine. 4:248-257
Background Ex vivo gene therapy in the central nervous system (CNS) holds great promise for diseases such as the neurodegenerative disorders. However, achieving stable, long-term transgene expression in grafted cells has proven problematic. This stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d35eb3d722b9249352bf35393307a40
https://doi.org/10.1002/jgm.268
https://doi.org/10.1002/jgm.268
Publikováno v:
BMC Biotechnology, Vol 9, Iss 1, p 13 (2009)
BMC Biotechnology
BMC Biotechnology
Background Lentiviral vectors hold great promise as gene transfer vectors in gene therapeutic settings. However, problems related to the risk of insertional mutagenesis, transgene silencing and positional effects have stalled the use of such vectors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffe0620c7d442e084487f09d4cb2d08d
http://www.biomedcentral.com/1472-6750/9/13
http://www.biomedcentral.com/1472-6750/9/13
Publikováno v:
Experimental cell research. 298(2)
Transplantation of genetically manipulated cells to the central nervous system holds great promise for the treatment of several severe neurological disorders. The success of this strategy relies on sufficient levels of transgene expression after tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ccf620614d78604d603a96b2f95ab76
https://pubmed.ncbi.nlm.nih.gov/15265707
https://pubmed.ncbi.nlm.nih.gov/15265707
Publikováno v:
International review of neurobiology. 55
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::be2b52ccdbaf49ed3cb41355840f35ca
https://pubmed.ncbi.nlm.nih.gov/12968533
https://pubmed.ncbi.nlm.nih.gov/12968533
Publisher Summary This chapter describes the different types of lentiviral vectors and discusses their use for gene transfer to the central nervous system (CNS). The lentiviral family consists of several viruses, both primate and nonprimate. The most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad8d161653426e84d8e7362b0baa5914
https://doi.org/10.1016/s0074-7742(03)01004-3
https://doi.org/10.1016/s0074-7742(03)01004-3
Autor:
Nina, Rosenqvist, Caroline, Hård Af Segerstad, Christofer, Samuelsson, Jens, Johansen, Cecilia, Lundberg
Publikováno v:
The journal of gene medicine. 4(3)
Ex vivo gene therapy in the central nervous system (CNS) holds great promise for diseases such as the neurodegenerative disorders. However, achieving stable, long-term transgene expression in grafted cells has proven problematic. This study reports t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b4999ef04efb3df1aae51873ee456c0
https://pubmed.ncbi.nlm.nih.gov/12112642
https://pubmed.ncbi.nlm.nih.gov/12112642