Zobrazeno 1 - 10 of 55 pro vyhledávání: '"Nina Orfali"'
1
Akademický článek
VEXAS syndrome as a cause for multifocal, relapsing head and neck inflammation
Autor: Aoife Heeney, Rachael Wu, Conall Fitzgerald, Nina Orfali, Nadim Akasheh, Conor Magee
Publikováno v: Clinical Case Reports, Vol 12, Iss 7, Pp n/a-n/a (2024)
Key Clinical Message VEXAS syndrome (vacuoles, E1 enzyme, X‐linked, autoinflammatory, somatic) is a novel autoinflammatory syndrome. We describe a case of VEXAS syndrome with upper airway and oral cavity involvement which are not well described in
Externí odkaz: https://doaj.org/article/dd91d21fe9be447096c185398dfc33dc
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2
Akademický článek
Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA‐induced differentiation of leukemic cells
Autor: Nina Orfali, Deborah Shan‐Krauer, Tracey R. O’Donovan, Nigel P. Mongan, Lorraine J. Gudas, Mary R. Cahill, Mario P. Tschan, Sharon L. McKenna
Publikováno v: Molecular Oncology, Vol 14, Iss 6, Pp 1297-1309 (2020)
Ubiquitin/ISG15‐conjugating enzyme E2L6 (UBE2L6) is a critical enzyme in ISGylation, a post‐translational protein modification that conjugates the ubiquitin‐like modifier, interferon‐stimulated gene 15 (ISG15), to target substrates. Previous
Externí odkaz: https://doaj.org/article/d6f2dd270c9a47d8aa678254a9db298c
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3
Akademický článek
All-Trans-Retinoic Acid Combined With Valproic Acid Can Promote Differentiation in Myeloid Leukemia Cells by an Autophagy Dependent Mechanism
Autor: Dalyia N. Benjamin, Tracey R. O’Donovan, Kristian B. Laursen, Nina Orfali, Mary R. Cahill, Nigel P. Mongan, Lorraine J. Gudas, Sharon L. McKenna
Publikováno v: Frontiers in Oncology, Vol 12 (2022)
Acute myeloid leukemia (AML) is an aggressive blood cancer with an overall survival of 30%. One form of AML, acute promyelocytic leukemia (APL) has become more than 90% curable with differentiation therapy, consisting of all-trans-retinoic acid (ATRA
Externí odkaz: https://doaj.org/article/ae6989dc6889441b8fad712bc28c5e5e
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