Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Nina Offermann"'
Autor:
Theodore S. Kapellos, Kevin Baßler, Wataru Fujii, Christina Nalkurthi, Anna C. Schaar, Lorenzo Bonaguro, Tal Pecht, Izabela Galvao, Shobhit Agrawal, Adem Saglam, Erica Dudkin, Amit Frishberg, Elena de Domenico, Arik Horne, Chantal Donovan, Richard Y. Kim, David Gallego-Ortega, Tessa E. Gillett, Meshal Ansari, Jonas Schulte-Schrepping, Nina Offermann, Ignazio Antignano, Burcu Sivri, Wenying Lu, Mathew S. Eapen, Martina van Uelft, Collins Osei-Sarpong, Maarten van den Berge, Hylke C. Donker, Harry J.M. Groen, Sukhwinder S. Sohal, Johanna Klein, Tina Schreiber, Andreas Feißt, Ali Önder Yildirim, Herbert B. Schiller, Martijn C. Nawijn, Matthias Becker, Kristian Händler, Marc Beyer, Melania Capasso, Thomas Ulas, Jan Hasenauer, Carmen Pizarro, Fabian J. Theis, Philip M. Hansbro, Dirk Skowasch, Joachim L. Schultze
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112525- (2023)
Summary: Systemic inflammation is established as part of late-stage severe lung disease, but molecular, functional, and phenotypic changes in peripheral immune cells in early disease stages remain ill defined. Chronic obstructive pulmonary disease (C
Externí odkaz:
https://doaj.org/article/de07677bc6c241f3a6d5cd66f2c12fd0
Autor:
Isabelle Arnoux, Michael Willam, Nadine Griesche, Jennifer Krummeich, Hirofumi Watari, Nina Offermann, Stephanie Weber, Partha Narayan Dey, Changwei Chen, Olivia Monteiro, Sven Buettner, Katharina Meyer, Daniele Bano, Konstantin Radyushkin, Rosamund Langston, Jeremy J Lambert, Erich Wanker, Axel Methner, Sybille Krauss, Susann Schweiger, Albrecht Stroh
Publikováno v:
eLife, Vol 7 (2018)
Catching primal functional changes in early, ‘very far from disease onset’ (VFDO) stages of Huntington’s disease is likely to be the key to a successful therapy. Focusing on VFDO stages, we assessed neuronal microcircuits in premanifest Hdh150
Externí odkaz:
https://doaj.org/article/031434054df44d4c9f2caf98fe3f48e2
Publikováno v:
Cellular and molecular life sciences 80(5), 126 (2023). doi:10.1007/s00018-023-04775-y
Microglia are the tissue-resident macrophage population of the brain, specialized in supporting the CNS environment and protecting it from endogenous and exogenous insults. Nonetheless, their function declines with age, in ways that remain to be full
Autor:
Julia P. Gerber, Jenny Russ, Vijay Chandrasekar, Nina Offermann, Hang-Mao Lee, Sarah Spear, Nicola Guzzi, Simona Maida, Sundararaghavan Pattabiraman, Ruoyu Zhang, Amir H. Kayvanjoo, Preeta Datta, Jagath Kasturiarachchi, Teresa Sposito, Natalia Izotova, Kristian Händler, Peter D. Adams, Teresa Marafioti, Tariq Enver, Jörg Wenzel, Marc Beyer, Elvira Mass, Cristian Bellodi, Joachim L. Schultze, Melania Capasso, Rachael Nimmo, Paolo Salomoni
Publikováno v:
Nature cell biology 23(12), 1224-1239 (2021). doi:10.1038/s41556-021-00774-y
Nature Cell Biology
Nature Cell Biology
Defective silencing of retrotransposable elements has been linked to inflammageing, cancer and autoimmune diseases. However, the underlying mechanisms are only partially understood. Here we implicate the histone H3.3 chaperone Daxx, a retrotransposab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee13b2bcc75258f28371f3d227cfcfb
https://pub.dzne.de/record/163640
https://pub.dzne.de/record/163640
Autor:
Julia P. Gerber, Jenny Russ, Vijay Chandrasekar, Nina Offermann, Hang-Mao Lee, Sarah Spear, Nicola Guzzi, Simona Maida, Sundararaghavan Pattabiraman, Ruoyu Zhang, Amir H. Kayvanjoo, Preeta Datta, Jagath Kasturiarachchi, Teresa Sposito, Natalia Izotova, Kristian Händler, Peter D. Adams, Teresa Marafioti, Tariq Enver, Jörg Wenzel, Marc Beyer, Elvira Mass, Cristian Bellodi, Joachim L. Schultze, Melania Capasso, Rachael Nimmo, Paolo Salomoni
Publikováno v:
Nature cell biology 24(1), 123 (2022). doi:10.1038/s41556-021-00833-4
Autor:
Ashraf Al-Amoudi, Kira Piotrowitz, Christian Lamberz, Kristina Hofmann, Nina Offermann, Anja Scheller, Diana But, Lars Kuerschner
Publikováno v:
Glia. 65:231-249
Although the brain controls all main metabolic pathways in the whole organism, its lipid metabolism is partially separated from the rest of the body. Circulating lipids and other metabolites are taken up into brain areas like the hypothalamus and are
Autor:
Michael T. Heneka, Lily Keane, Ignazio Antignano, Ai Nagano, Jun Wang, Claude Chelala, Sean-Patrick Riechers, Patrick Neil McCormick, Raphael Zollinger, Paolo Salomoni, Yvonne Biederbick, Anaelle A Dumas, Dario Tejera, Melania Capasso, Frederike Graelmann, Maria Eugenia Bernis, Nina Offermann, Julia Esser, Annett Halle, Jenny Russ
Publikováno v:
J Clin Invest
The journal of clinical investigation 131(1), e132727 (2021). doi:10.1172/JCI132727
The journal of clinical investigation 131(1), e132727 (2021). doi:10.1172/JCI132727
Microglia maintain homeostasis in the brain. However, with age, they become primed and respond more strongly to inflammatory stimuli. We show here that microglia from aged mice had upregulated mTOR complex 1 signaling controlling translation, as well
Autor:
Hirofumi Watari, Sybille Krauss, Katharina Meyer, Sven Buettner, Isabelle Arnoux, Axel Methner, Rosamund F. Langston, Nina Offermann, Daniele Bano, Konstantin Radyushkin, Jennifer Krummeich, Partha Narayan Dey, Erich E. Wanker, Jeremy J. Lambert, Stephanie Weber, Susann Schweiger, Olivia Monteiro, Nadine Griesche, Changwei Chen, Albrecht Stroh, Michael Willam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d264c210d5b7c6d3b9fe835ae7698487
https://doi.org/10.7554/elife.38744.032
https://doi.org/10.7554/elife.38744.032
Autor:
Jennifer Krummeich, Jeremy J. Lambert, Axel Methner, Sven Buettner, Isabelle Arnoux, Hirofumi Watari, Nina Offermann, Daniele Bano, Sybille Krauss, Michael Willam, Albrecht Stroh, Konstantin Radyushkin, Erich E. Wanker, Susann Schweiger, Olivia Monteiro, Stephanie Weber, Rosamund F. Langston, Partha Narayan Dey, Nadine Griesche, Changwei Chen, Katharina Meyer
Publikováno v:
eLife 7, e38744 (2018). doi:10.7554/eLife.38744
eLife, Vol 7 (2018)
eLife, Vol 7 (2018)
Catching primal functional changes in early, ‘very far from disease onset’ (VFDO) stages of Huntington’s disease is likely to be the key to a successful therapy. Focusing on VFDO stages, we assessed neuronal microcircuits in premanifest Hdh150
Autor:
Jenny Desantis, Anna Bochicchio, Nina Offermann, Judith Schilling, Frank Matthes, Erich E. Wanker, Stephanie Weber, Paolo Carloni, Sybille Krauss, Giulia Rossetti, Oriana Tabarrini, Kenji Schorpp, Kamyar Hadian, Serena Massari
Publikováno v:
ACS chemical neuroscience 9(6), 1399-1408 (2018). doi:10.1021/acschemneuro.8b00027
Expanded CAG trinucleotide repeats in Huntington's disease (HD) are causative for neurotoxicity. The mutant CAG repeat RNA encodes neurotoxic polyglutamine proteins and can lead to a toxic gain of function by aberrantly recruiting RNA-binding protein