Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Nina N Nupponen"'
Autor:
Juho Miettinen, Philipp Sergeev, Sadiksha Adhikari, Maiju-Emilia Huppunen, Minna Suvela, Ana Slipicevic, Nina N Nupponen, Klara Acs, Fredrik Lehmann, Caroline Heckman
Publikováno v:
HemaSphere, Vol 7, p e9358540 (2023)
Externí odkaz:
https://doaj.org/article/b5e07e40eb0946358c2f67ca8dcfbc15
Autor:
Ken Flanagan, Romika Kumari, Juho J. Miettinen, Staci L. Haney, Michelle L. Varney, Jacob T. Williams, Muntasir M. Majumder, Minna Suvela, Ana Slipicevic, Fredrik Lehmann, Nina N. Nupponen, Sarah A. Holstein, Caroline A. Heckman
Publikováno v:
HemaSphere, Vol 6, Iss 3, p e687 (2022)
Immunoglobulin light-chain (AL) amyloidosis is a rare disease caused by clonal plasma cell secretion of misfolded light chains that assemble as toxic amyloid fibrils, depositing in vital organs including the heart and kidneys, causing organ dysfuncti
Externí odkaz:
https://doaj.org/article/9b8d9fd8a74e40a7942a0ec1bf52d4d7
Autor:
Arjen Gebraad, Roope Ohlsbom, Juho J. Miettinen, Promise Emeh, Toni-Karri Pakarinen, Mikko Manninen, Antti Eskelinen, Kirsi Kuismanen, Ana Slipicevic, Fredrik Lehmann, Nina N. Nupponen, Caroline A. Heckman, Susanna Miettinen
Publikováno v:
Cells, Vol 11, Iss 9, p 1574 (2022)
Mesenchymal stem/stromal cells (MSCs) are self-renewing and multipotent progenitors, which constitute the main cellular compartment of the bone marrow stroma. Because MSCs have an important role in the pathogenesis of multiple myeloma, it is essentia
Externí odkaz:
https://doaj.org/article/d9cff7016b3741deb6937edcdb9319eb
Autor:
Muntasir Mamun Majumder, Romika Kumari, Nina N. Nupponen, Raija Silvennoinen, Pekka Anttila, Juha Lievonen, Fredrik Lehmann, Caroline A. Heckman
Publikováno v:
British Journal of Cancer
Background Esterase enzymes differ in substrate specificity and biological function and may display dysregulated expression in cancer. This study evaluated the biological significance of esterase expression in multiple myeloma (MM). Methods For gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e4f662a4221b060de0878d33e861a86
https://doi.org/10.1038/s41416-020-01237-1
https://doi.org/10.1038/s41416-020-01237-1
Autor:
Ana Slipicevic, Caroline A. Heckman, Sadiksha Adhikari, Nina N. Nupponen, Philipp Sergeev, Minna Suvela, Fredrik Lehmann, Maiju-Emilia Huppunen, Juho J. Miettinen
Publikováno v:
Blood. 138:1194-1194
Introduction Melphalan flufenamide (melflufen), is a novel peptide-drug conjugate that targets aminopeptidases and selectively delivers alkylating agents in tumors. Melflufen was recently FDA approved for the treatment of relapsed/refractory multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03565780b1ab53edb2750ac7b4e8689c
https://doi.org/10.1182/blood-2021-147191
https://doi.org/10.1182/blood-2021-147191
Autor:
Nina N. Nupponen, Kenneth C. Anderson, Paul G. Richardson, Joachim Gullbo, Dharminder Chauhan, Fredrik Lehmann, Arghya Ray, Ting Du, Jakob Lindberg
Publikováno v:
Blood. 138:4357-4357
Introduction Melphalan flufenamide (Melflufen; Oncopeptides AB) is a novel enzyme-activated analogue of melphalan that enables a more rapid and higher intracellular accumulation of melphalan in tumor cells than is achievable by direct exposure to equ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f82e4a5d8db88f6af666453afa5d0524
https://doi.org/10.1182/blood-2021-153705
https://doi.org/10.1182/blood-2021-153705
Autor:
Caroline A. Heckman, Thorsten Stühmer, Juho J. Miettinen, Maria-Victoria Mateos, Johan Aschan, Paul G. Richardson, Nina N. Nupponen, Ralf C. Bargou, Paula Rodriguez Otero, Maiju-Emilia Huppunen, Fredrik Lehmann, Ana Slipicevic, Umair Munawar
Publikováno v:
Cancer Research. 80:1843-1843
Introduction Multiple myeloma (MM) is an incurable plasma cell malignancy characterized by clonal evolution and heterogeneous genetic abnormalities. Deletion of the short arm of chromosome 17 (del17p) harboring TP53 is a high-risk abnormality associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8748a794b6aa27564015a16b1ef738f7
https://doi.org/10.1158/1538-7445.am2020-1843
https://doi.org/10.1158/1538-7445.am2020-1843
Autor:
Raija Silvennoinen, Caroline A. Heckman, Pekka Anttila, Juha Lievonen, Romika Kumari, Fredrik Lehmann, Mamun Majumder, Nina N. Nupponen
Publikováno v:
Cancer Research. 80:190-190
Introduction: The esterase enzyme family is a subclass of the hydrolase enzyme superfamily that functions to split ester bonds. Several esterases have been identified, which differ in substrate specificity and biological function, and the expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69e9a1be15c8c0ce6f7e59fb908939a5
https://doi.org/10.1158/1538-7445.am2020-190
https://doi.org/10.1158/1538-7445.am2020-190
Autor:
Caroline A. Heckman, Minna Suvela, Muntasir Mamun Majumder, Fredrik Lehmann, Sarah A. Holstein, Ana Slipicevic, Ken Flanagan, Juho J. Miettinen, Romika Kumari, Michelle L. Varney, Nina N. Nupponen
Publikováno v:
Blood. 134:3100-3100
Background: Immunoglobulin light-chain (AL) amyloidosis is a rare disease caused by plasma cell secretion of misfolded light chains that assemble as amyloid fibrils and deposit on vital organs including the heart and kidneys, causing organ dysfunctio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09cba085e93f61e7fbfbe69577b8f664
https://doi.org/10.1182/blood-2019-125952
https://doi.org/10.1182/blood-2019-125952
Autor:
Mirja Ruutu, Nina N. Nupponen, Greetta Joensuu, Akseli Hemminki, Timo Joensuu, Sari Pesonen, Juhani Collan
Publikováno v:
Acta Oncologica. 51:130-133
Prostate cancer recurrence after therapy with curative intent is often first detected as an increase in prostate-specific antigen (PsA) (“rising PsA syndrome”) which may occur years in advance of clinical recurrence, and may present on opportunit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::725d10a630677f298839ce282a9627da
https://doi.org/10.3109/0284186x.2011.617387
https://doi.org/10.3109/0284186x.2011.617387