Drug-biomarker co-development in oncology – 20 years and counting

Autor: Baolin Zhang, Nina N. Brahme, Julianne D. Twomey

Publikováno v: Drug Resistance Updates. 30:48-62

Predictive biomarkers for oncology are necessary to accurately identify patients who will benefit from anticancer treatment. Recently approved oncology drugs target discrete molecular aberrations or pathways in tumor cells and consequently are active

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f18b6253bf86f216ae4f51dee607f1
https://doi.org/10.1016/j.drup.2017.02.002

Kindlin Binds Migfilin Tandem LIM Domains and Regulates Migfilin Focal Adhesion Localization and Recruitment Dynamics

Autor: Srikala Raghavan, David S. Harburger, Madeline Parsons, Rachel M. Stewart, Karl Kemp-O'Brien, David A. Calderwood, Nina N. Brahme

Publikováno v: Journal of Biological Chemistry. 288:35604-35616

Focal adhesions (FAs), sites of tight adhesion to the extracellular matrix, are composed of clusters of transmembrane integrin adhesion receptors and intracellular proteins that link integrins to the actin cytoskeleton and signaling pathways. Two int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d217dd09fd2aee327d8eebed3c6e1f7
https://doi.org/10.1074/jbc.m113.483016

Cell Adhesion: A FERM Grasp of the Tail Sorts Out Integrins

Autor: Nina N. Brahme, David A. Calderwood

Publikováno v: Current Biology. 22:R692-R694

Integrins are heterodimeric αβ transmembrane receptors that play key roles in cellular physiology and pathology. Accumulating data indicate that the two NPxY motifs in the cytoplasmic domain of the β1 subunit synergistically promote integrin activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a70cacc59202c19d4007ac83bf0cea
https://doi.org/10.1016/j.cub.2012.07.049

A conserved lipid-binding loop in the kindlin FERM F1 domain is required for kindlin-mediated αIIbβ3 integrin coactivation

Autor: Benjamin T. Goult, Clotilde Huet-Calderwood, David A. Calderwood, Nina N. Brahme, Igor L. Barsukov, Mohamed Bouaouina, Neil Bate, David R. Critchley

Publikováno v: The Journal of biological chemistry. 287(10)

The activation of heterodimeric integrin adhesion receptors from low to high affinity states occurs in response to intracellular signals that act on the short cytoplasmic tails of integrin beta subunits. Binding of the talin FERM (four-point-one, ezr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::020853ec3ed73d9c88621797549b89ae
https://pubmed.ncbi.nlm.nih.gov/22235127

The Mannose in the Mirror: A Reflection on the Pharmacokinetic Impact of High Mannose Glycans of Monoclonal Antibodies in Biosimilar Development.

Autor: Welch J; US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Product Quality, Office of Biotechnology Products, Silver Spring, Maryland, USA., Ausin C; US Food and Drug Administration, Center for Drug Evaluation and Research, Office of New Drugs, Office of Therapeutic Biologics and Biosimilars, Silver Spring, Maryland, USA., Brahme N; US Food and Drug Administration, Center for Drug Evaluation and Research, Office of New Drugs, Office of Therapeutic Biologics and Biosimilars, Silver Spring, Maryland, USA., Lacana E; US Food and Drug Administration, Center for Drug Evaluation and Research, Office of New Drugs, Office of Therapeutic Biologics and Biosimilars, Silver Spring, Maryland, USA., Ricci S; US Food and Drug Administration, Center for Drug Evaluation and Research, Office of New Drugs, Office of Therapeutic Biologics and Biosimilars, Silver Spring, Maryland, USA., Schultz-DePalo M; US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Product Quality, Office of Biotechnology Products, Silver Spring, Maryland, USA.

Publikováno v: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2023 May; Vol. 113 (5), pp. 1003-1010. Date of Electronic Publication: 2022 Nov 21.