Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nina N, Hosmane"'
Autor:
Erik C Hansen, Monica Ransom, Jay R Hesselberth, Nina N Hosmane, Adam A Capoferri, Katherine M Bruner, Ross A Pollack, Hao Zhang, Michael Bradley Drummond, Janet M Siliciano, Robert Siliciano, James T Stivers
Publikováno v:
eLife, Vol 5 (2016)
We report that a major subpopulation of monocyte-derived macrophages (MDMs) contains high levels of dUTP, which is incorporated into HIV-1 DNA during reverse transcription (U/A pairs), resulting in pre-integration restriction and post-integration mut
Externí odkaz:
https://doaj.org/article/db3a368d8fbf4bbfb556874b4bc89f4b
Autor:
Daniel I. S. Rosenbloom, Robert F. Siliciano, Kyungyoon J. Kwon, Brandon F. Keele, Adam A. Capoferri, Janet D. Siliciano, Katherine M. Bruner, Ya Chi Ho, Subul A. Beg, Nina N. Hosmane
Publikováno v:
The Journal of Experimental Medicine
The latent reservoir for HIV-1 in resting CD4+ T cells prevents cure with antiretroviral therapy. Hosmane et al. provide evidence supporting the hypothesis that a larger fraction of cells in the reservoir is generated by cell proliferation than by di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f40a8d33dc387e7419ff7d5be6c705
http://europepmc.org/articles/PMC5379987
http://europepmc.org/articles/PMC5379987
Autor:
Robert F. Siliciano, Adam A. Capoferri, Evelyn E. Gurule, Kyungyoon J. Kwon, Subul A. Beg, Alison L. Hill, Janet D. Siliciano, Zheng Wang, Timothy P. Brennan, Nina N. Hosmane, Mithra Kumar, Ya Chi Ho, Jeffrey M. Gerold, Stuart C. Ray
The latent reservoir for HIV-1 in resting CD4+ T cells is a major barrier to cure. Several lines of evidence suggest that the latent reservoir is maintained through cellular proliferation. Analysis of this proliferative process is complicated by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5057b0d7f11442972c0265798ed06c7
https://europepmc.org/articles/PMC5856552/
https://europepmc.org/articles/PMC5856552/
Autor:
Liang, Shan, Kai, Deng, Hongbo, Gao, Sifei, Xing, Adam A, Capoferri, Christine M, Durand, S Alireza, Rabi, Gregory M, Laird, Michelle, Kim, Nina N, Hosmane, Hung-Chih, Yang, Hao, Zhang, Joseph B, Margolick, Linghua, Li, Weiping, Cai, Ruian, Ke, Richard A, Flavell, Janet D, Siliciano, Robert F, Siliciano
Publikováno v:
Immunity. 47(4)
The latent reservoir for HIV-1 in resting memory CD4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cf54d60958a7f5fb01dcda435877a59e
https://pubmed.ncbi.nlm.nih.gov/29045893
https://pubmed.ncbi.nlm.nih.gov/29045893
Autor:
Adam A. Capoferri, Robert F. Siliciano, Nina N. Hosmane, Michelle Kim, Hung-Chih Yang, C. Korin Bullen, Janet D. Siliciano
Publikováno v:
Nature Protocols. 9:2755-2770
A mechanistic understanding of HIV-1 latency depends on a model system that recapitulates the in vivo condition of latently infected, resting CD4(+) T lymphocytes. Latency seems to be established after activated CD4(+) T cells, the principal targets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f69d78d1f43b2a9fe6201895d3f49355
https://doi.org/10.1038/nprot.2014.188
https://doi.org/10.1038/nprot.2014.188
Autor:
Robert F. Siliciano, Erik Verschueren, Ryan J. Conrad, Jonathan K.L. Chan, Nevan J. Krogan, Emilie Besnard, Warner C. Greene, Jonathan S. Weissman, Michael C. Bassik, Martin Kampmann, J. Peter Svensson, Shweta Hakre, Melanie Ott, Andrea Gramatica, Hyung W. Lim, Nina N. Hosmane, Emilie Battivelli, Eric Verdin, Alyssa R. Martin
Publikováno v:
Cell host & microbe, vol 20, iss 6
A population of CD4T lymphocytes harboring latent HIV genomes can persist in patients on antiretroviral therapy, posing a barrier to HIV eradication. To examine cellular complexes controlling HIV latency, we conducted a genome-wide screen with a pool
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f5a766ce7745fc5572ac44cd9d8f78
https://europepmc.org/articles/PMC5354304/
https://europepmc.org/articles/PMC5354304/
Autor:
Liang Shan, Sarah B. Laskey, Daniel I. S. Rosenbloom, Jeffrey C. Wang, Nina N. Hosmane, Janet D. Siliciano, Jun Lai, Ya Chi Ho, Joel N. Blankson, Robert F. Siliciano
Publikováno v:
Cell. 155:540-551
SummaryAntiretroviral therapy fails to cure HIV-1 infection because latent proviruses persist in resting CD4+ T cells. T cell activation reverses latency, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::494a5e48e9b915cb67a38ec03a07f49e
https://doi.org/10.1016/j.cell.2013.09.020
https://doi.org/10.1016/j.cell.2013.09.020
Autor:
Jay R. Hesselberth, Janet M. Siliciano, Robert F. Siliciano, Hao Zhang, James T. Stivers, Katherine M. Bruner, Monica Ransom, Adam A. Capoferri, Erik C Hansen, M.B. Drummond, Ross A. Pollack, Nina N. Hosmane
Publikováno v:
eLife, Vol 5 (2016)
eLife
eLife
We report that a major subpopulation of monocyte-derived macrophages (MDMs) contains high levels of dUTP, which is incorporated into HIV-1 DNA during reverse transcription (U/A pairs), resulting in pre-integration restriction and post-integration mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ea88b52727ac6ba47b3da79cf8a025
https://doi.org/10.7554/elife.18447
https://doi.org/10.7554/elife.18447
Autor:
Robert F. Siliciano, James T. Stivers, Janet M. Siliciano, Jay R. Hesselberth, Nina N. Hosmane, Adam A. Capoferri, Ross A. Pollack, Erik C Hansen, Monica Ransom, Hao Zhang, M.B. Drummond, Katherine M. Bruner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d34ab008342496b06edc5f86a12cad8
https://doi.org/10.7554/elife.18447.030
https://doi.org/10.7554/elife.18447.030
Autor:
Robert F. Siliciano, Nina N. Hosmane, Linghua Li, S. Alireza Rabi, Liang Shan, Gregory M. Laird, Janet D. Siliciano, Hongbo Gao, Joseph B. Margolick, Sifei Xing, Christine M. Durand, Richard A. Flavell, Hao Zhang, Ruian Ke, Kai Deng, Hung-Chih Yang, Weiping Cai, Adam A. Capoferri, Michelle Kim
Publikováno v:
Immunity. 47:766-775.e3
The latent reservoir for HIV-1 in resting memory CD4+ T cells is the major barrier to curing HIV-1 infection. Studies of HIV-1 latency have focused on regulation of viral gene expression in cells in which latent infection is established. However, it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50fa9d15a2f9832e5b67357ceeda1f31
https://doi.org/10.1016/j.immuni.2017.09.014
https://doi.org/10.1016/j.immuni.2017.09.014