FGF21, a liver hormone that inhibits alcohol intake in mice, increases in human circulation after acute alcohol ingestion and sustained binge drinking at Oktoberfest

Autor: Susanna Søberg, Emilie S. Andersen, Niels B. Dalgaard, Ida Jarlhelt, Nina L. Hansen, Nina Hoffmann, Tina Vilsbøll, Anne Chenchar, Michal Jensen, Trisha J. Grevengoed, Sam A.J. Trammell, Filip K. Knop, Matthew P. Gillum

Publikováno v: Molecular Metabolism, Vol 11, Iss , Pp 96-103 (2018)

Objective: Excessive alcohol consumption is a leading cause of global morbidity and mortality. However, knowledge of the biological factors that influence ad libitum alcohol intake may be incomplete. Two large studies recently linked variants in the

Externí odkaz: https://doaj.org/article/be529766243b460f82294547288d04a1

GIP and GLP-1 Potentiate Sulfonylurea-Induced Insulin Secretion in Hepatocyte Nuclear Factor 1α Mutation Carriers

Autor: Kathrine Rose, Filip K. Knop, Nina L. Hansen, Torben Hansen, Sofie Hædersdal, Tina Vilsbøll, Alexander S. Christensen, Jens J. Holst, Heidi Storgaard

Publikováno v: Diabetes

Sulfonylureas (SUs) provide an efficacious first-line treatment in patients with hepatocyte nuclear factor 1α (HNF1A) diabetes, but SUs have limitations due to risk of hypoglycemia. Treatment based on the incretin hormones glucose-dependent insulino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb4da958f9030f238f2cd9e34f267b1
https://doi.org/10.2337/db20-0074

The role of GLP-1 in the postprandial effects of acarbose in type 2 diabetes

Autor: Signe Stensen, Tina Vilsbøll, Bolette Hartmann, Jens F. Rehfeld, Filip K. Knop, Niels B. Dalsgaard, Laura S. Hansen, Nina L. Hansen, Lærke S. Gasbjerg, Jens J. Holst

Publikováno v: European journal of endocrinology. 184(3)

Aims The alpha-glucosidase inhibitor acarbose is believed to reduce plasma glucose by delaying hydrolysis of carbohydrates. Acarbose-induced transfer of carbohydrates to the distal parts of the intestine increases circulating glucagon-like peptide 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e4930a210060a316d983977ba40c22
https://pubmed.ncbi.nlm.nih.gov/33449919

1145-P: Acarbose-Induced Glucagon-Like Peptide-1 Secretion Contributes to the Glucose-Lowering Effect of Acarbose

Autor: Filip K. Knop, Tina Vilsbøll, Laura S. Hansen, Jens J. Holst, Niels B. Dalsgaard, Signe Stensen, Lærke S. Gasbjerg, Nina L. Hansen, Bolette Hartmann

Publikováno v: Diabetes. 68

The glucose-lowering alpha-glucosidase inhibitor acarbose, is believed to act by delaying digestion and absorption of dietary carbohydrates. It has been shown that acarbose increases circulating glucagon-like peptide 1 (GLP-1). Using the GLP-1 recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b01f6c853bfde4549e61df5a118d3053
https://doi.org/10.2337/db19-1145-p

Glucagon-Like Peptide 2 Inhibits Postprandial Gallbladder Emptying in Man: A Randomized, Double-Blinded, Crossover Study

Autor: David P. Sonne, Tina Vilsbøll, Bolette Hartmann, Alexander S. Christensen, Nina L. Hansen, Filip K. Knop, Christina Nexøe-Larsen, Andreas Brønden, Jens F. Rehfeld, Jens J. Holst, Nicolai J Wever Albretchsen

Publikováno v: Clinical and Translational Gastroenterology
Hansen, N L, Bronden, A, Nexoe-Larsen, C C, Christensen, A S, Sonne, D P, Rehfeld, J F, Wever Albretchsen, N J, Hartmann, B, Vilsbøll, T, Holst, J J & Knop, F K 2020, ' Glucagon-Like Peptide 2 Inhibits Postprandial Gallbladder Emptying in Man : A Randomized, Double-Blinded, Crossover Study ', Clinical and Translational Gastroenterology, vol. 11, no. 12, e00257 . https://doi.org/10.14309/ctg.0000000000000257

INTRODUCTION: A recent study in mice points to the gut-derived hormone glucagon-like peptide 2 (GLP-2) as an important regulator of gallbladder motility inducing gallbladder relaxation and refilling. In this study, we evaluated the effect of exogenou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732090212b6b567ce4e006c8c98bff8d
https://doi.org/10.14309/ctg.0000000000000257