Prevention of Diet-Induced Obesity Effects on Body Weight and Gut Microbiota in Mice Treated Chronically with Δ9-Tetrahydrocannabinol.

Autor: Nina L Cluny, Catherine M Keenan, Raylene A Reimer, Bernard Le Foll, Keith A Sharkey

Publikováno v: PLoS ONE, Vol 10, Iss 12, p e0144270 (2015)

Acute administration of cannabinoid CB1 receptor agonists, or the ingestion of cannabis, induces short-term hyperphagia. However, the incidence of obesity is lower in frequent cannabis users compared to non-users. Gut microbiota affects host metaboli

Externí odkaz: https://doaj.org/article/f72042317a744917959e441a0c1d4132

Colitis-Induced Microbial Perturbation Promotes Postinflammatory Visceral Hypersensitivity

Autor: Nicolas Esquerre, Dominique Bihan, Alana Schick, Yasmin Nasser, Manon Defaye, Fernando A. Vicentini, Lilian Basso, Keith A. Sharkey, Christophe Altier, Simon A. Hirota, Ian A. Lewis, Nina L. Cluny, Humberto Jijon, Markus B. Geuking

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 2, Pp 225-244 (2020)

Background & Aims Despite achieving endoscopic remission, more than 20% of inflammatory bowel disease patients experience chronic abdominal pain. These patients have increased rectal transient receptor potential vanilloid-1 receptor (TRPV1) expressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed1dcda8afaf3b78c0b7073da88d285f
http://europepmc.org/articles/PMC7301239

Brain TNF drives post-inflammation depression-like behavior and persistent pain in experimental arthritis

Autor: Mark G. Swain, William Antonio Gonçalves, Derek M. McKay, Wagdi Almishri, Lateece Griffin, Keith A. Sharkey, Simon A. Hirota, Alexander J. Mathews, Nina L. Cluny, Benjamin H. Lee, Fernando Lopes, Vanessa Pinho, Fernando A. Vicentini, Quentin J. Pittman

Publikováno v: Brain, behavior, and immunity. 89

Patients with rheumatoid arthritis experience chronic pain, depression and fatigue, even when inflammation of the joints is well controlled. To study the relationship between arthritis, depression, and sustained pain when articular inflammation is no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32bc14d47426526409b803e8300204fa
https://pubmed.ncbi.nlm.nih.gov/32592863

Altered Brain Excitability and Increased Anxiety in Mice With Experimental Colitis: Consideration of Hyperalgesia and Sex Differences

Autor: Kewir D. Nyuyki, Nina L. Cluny, Mark G. Swain, Keith A. Sharkey, Quentin J. Pittman

Publikováno v: Frontiers in Behavioral Neuroscience
Frontiers in Behavioral Neuroscience, Vol 12 (2018)

Crohn’s disease (CD) and ulcerative colitis (UC) are incurable lifelong inflammatory bowel diseases (IBD) with a rising worldwide incidence. IBD is characterized by diarrhea, rectal bleeding, severe cramping and weight loss. However, there is a gro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce9eead977d8c6fd53c166a5a55593c
http://europepmc.org/articles/PMC5893896

Interactive effects of oligofructose and obesity predisposition on gut hormones and microbiota in diet-induced obese rats

Autor: Catherine M. Keenan, Keith A. Sharkey, Lindsay K. Eller, Nina L. Cluny, Raylene A. Reimer

Publikováno v: Obesity. 23:769-778

Objective Oligofructose (OFS) is a prebiotic that reduces energy intake and fat mass via changes in gut satiety hormones and microbiota. The effects of OFS may vary depending on predisposition to obesity. The aim of this study was to examine the effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::792eb0bae03cda71e78a85c4e9b647af
https://doi.org/10.1002/oby.21017