Výsledky vyhledávání - "Nina Korzeniewski"

Akademický článek

Targeting the Proteasome in Advanced Renal Cell Carcinoma: Complexity and Limitations of Patient-Individualized Preclinical Drug Discovery

Autor: Jielin Li, Laura Pohl, Julia Schüler, Nina Korzeniewski, Philipp Reimold, Adam Kaczorowski, Weibin Hou, Stefanie Zschäbitz, Cathleen Nientiedt, Dirk Jäger, Markus Hohenfellner, Anette Duensing, Stefan Duensing

Publikováno v: Biomedicines, Vol 9, Iss 6, p 627 (2021)

Background: Systemic treatment options for metastatic renal cell carcinoma (RCC) have significantly expanded in recent years. However, patients refractory to tyrosine kinase and immune checkpoint inhibitors still have limited treatment options and pa

Externí odkaz: https://doaj.org/article/0740d2de24fd4f58a3d8aff6f0f9c863

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Akademický článek

Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)

It has been increasingly recognised that tumours are not made up of a homogeneous population of cells. Here, the authors show heterogeneous expression of five protein markers in renal cell cancer and demonstrate that the progression of the tumour doe

Externí odkaz: https://doaj.org/article/6b8b3ea588cd4746baa64e76cce15f72

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Akademický článek

Prognostic Significance and Functional Role of CEP57 in Prostate Cancer

Autor: Josef Mang, Nina Korzeniewski, Dimo Dietrich, Verena Sailer, Yanis Tolstov, Sam Searcy, Jost von Hardenberg, Sven Perner, Glen Kristiansen, Alexander Marx, Wilfried Roth, Esther Herpel, Carsten Grüllich, Valentin Popeneciu, Sascha Pahernik, Boris Hadaschik, Markus Hohenfellner, Stefan Duensing

Publikováno v: Translational Oncology, Vol 8, Iss 6, Pp 487-496 (2015)

We have recently shown that centrosomal protein 57 (CEP57) is overexpressed in a subset of human prostate cancers. CEP57 is involved in intracellular transport processes, and its overexpression causes mitotic defects as well as abnormal microtubule n

Externí odkaz: https://doaj.org/article/b04777fa3d1e4db79f8ebebf4641d25c

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Akademický článek

CAND1 Promotes PLK4-Mediated Centriole Overduplication and Is Frequently Disrupted in Prostate Cancer

Autor: Nina Korzeniewski, Markus Hohenfellner, Stefan Duensing

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 9, Pp 799-806 (2012)

Centrosomes play a crucial role in the maintenance of genome stability by orchestrating bipolar mitotic spindle formation. The centrosome normally duplicates precisely once before mitosis in a process that is extensively regulated by protein degradat

Externí odkaz: https://doaj.org/article/62f98d946c1e43fe98185a1048160450

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