Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Nina K Jain"'
Publikováno v:
eLife, Vol 12 (2024)
Recombinant adeno-associated viruses (rAAVs) are the predominant gene therapy vector. Several rAAV vectored therapies have achieved regulatory approval, but production of sufficient rAAV quantities remains difficult. The AAV Rep proteins, which are e
Externí odkaz:
https://doaj.org/article/fc3d27322d8842f3ac88f95d8b811992
Recombinant adeno-associated viruses (rAAVs) are the predominant gene therapy vector. Several rAAV vectored therapies have achieved regulatory approval, but production of sufficient rAAV quantities remains difficult. The AAV Rep proteins, which are e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb40df3d4efb4ab058e6bed537700adb
https://doi.org/10.1101/2023.01.31.526541
https://doi.org/10.1101/2023.01.31.526541
Publikováno v:
Human Mutation
Lysosomal acid lipase (LAL) deficiency is an autosomal recessive disorder caused by LIPA gene mutations that disrupt LAL activity. We performed in vitro functional testing of 149 LIPA variants to increase the understanding of the variant effects on L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d13b30ce9364aae8e3c6137c64cd8b
http://europepmc.org/articles/PMC6852163
http://europepmc.org/articles/PMC6852163
Autor:
Drew H, Bryant, Ali, Bashir, Sam, Sinai, Nina K, Jain, Pierce J, Ogden, Patrick F, Riley, George M, Church, Lucy J, Colwell, Eric D, Kelsic
Publikováno v:
Nature biotechnology. 39(6)
Modern experimental technologies can assay large numbers of biological sequences, but engineered protein libraries rarely exceed the sequence diversity of natural protein families. Machine learning (ML) models trained directly on experimental data wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::90a5ca7068d4366f7c5c461c737f4f69
https://pubmed.ncbi.nlm.nih.gov/33574611
https://pubmed.ncbi.nlm.nih.gov/33574611
Autor:
Fang Sun, Susan Barkowski-Clark, Rekha Patel, Tadas Panavas, Nina K. Jain, Richard Altman, Voegtli Walter C, Alinafe Mpanda, Jian Liu, Alyssa Neill, Jonathan Zmuda, Krista Johnson, Henry Chiou, Adriana Kita, Robert Ballinger, Ryan Schulz, Brian P. Huta, Chao Yan Liu
Publikováno v:
Protein expression and purification. 134
Chinese Hamster Ovary (CHO) cells are the principal mammalian host used for stable cell line generation and biotherapeutic protein production. Until recently, production of milligrams to grams of protein in CHO transient systems was challenging. As s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02d0f83991f3600f3760a4cf897f94fc
https://pubmed.ncbi.nlm.nih.gov/28342833
https://pubmed.ncbi.nlm.nih.gov/28342833
Publikováno v:
Molecular Pharmaceutics
Biomimetic in vitro intestinal models are becoming useful tools for studying host-microbial interactions. In the past, these models have typically been limited to simple cultures on 2-D scaffolds or Transwell inserts, but it is widely understood that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::261fc1a0ad1832bc4a86e32da1c9616a
http://europepmc.org/articles/PMC4096232
http://europepmc.org/articles/PMC4096232
Autor:
Nina K. Jain, John C. March, David J. Hackam, Jia Hongpeng, Jiajie Yu, Shahab Shaffiey, Cait M. Costello
Publikováno v:
Biotechnology and Bioengineering. 111:1222-1232
In vitro intestinal models can provide new insights into small intestinal function, including cellular growth and proliferation mechanisms, drug absorption capabilities, and host-microbial interactions. These models are typically formed with cells cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b872168a4929fdc68f5908c78d315d80
https://doi.org/10.1002/bit.25180
https://doi.org/10.1002/bit.25180
Novel NAGLU variants associated with MPS IIIB and in vitro analysis of residual enzymatic activities
Autor:
Nina K. Jain, Maria L. Escolar, Suresh Vijay, Chris Forbes, Rui-ru Ji, Andrew Hutchinson, Kiran C. Patki, Chester B. Whitley, Frits A. Wijburg, Roberto Giugliani, Gillian Bubb
Publikováno v:
Molecular Genetics and Metabolism. 120:S71
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea8cec67be2fd9315d9390d65abd41fb
https://doi.org/10.1016/j.ymgme.2016.11.167
https://doi.org/10.1016/j.ymgme.2016.11.167