Zobrazeno 1 - 10
of 221
pro vyhledávání: '"Nina Isoherranen"'
Autor:
Ogochukwu U. Amaeze, Nina Isoherranen
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 11, Pp 2163-2176 (2023)
Abstract Pregnancy can increase the risk of latent tuberculosis infection (LTBI) progression to tuberculosis (TB) disease. Isoniazid (INH) is the preferred preventative treatment for LTBI in pregnancy. INH is mainly cleared by N‐acetyltransferase 2
Externí odkaz:
https://doaj.org/article/a5882e6e05c44aa7a97309f50c2691c1
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 1, Pp n/a-n/a (2024)
Abstract Kidney function‐adjusted drug dosing is currently based solely on the estimated glomerular filtration rate (GFR), however, kidney drug handling is accomplished by a combination of filtration, tubular secretion, and re‐absorption. Mechani
Externí odkaz:
https://doaj.org/article/fd27fa7ae8e745ce9d6ffbee8b8c327d
Autor:
Nelly R. Mugo, Victor Mudhune, Renee Heffron, Katherine K. Thomas, Eleanor McLellan-Lemal, Betty Njoroge, Sue Peacock, Siobhán M. O’Connor, Beatrice Nyagol, Eunice Ouma, Renee Ridzon, Jeffrey Wiener, Nina Isoherranen, David W. Erikson, Louise A. Ouattara, Nazita Yousefieh, Terry A. Jacot, Richard E. Haaland, Susan A. Morrison, Harald S. Haugen, Andrea R. Thurman, Shannon A. Allen, Jared M. Baeten, Taraz Samandari, Gustavo F. Doncel
Publikováno v:
Frontiers in Reproductive Health, Vol 5 (2023)
IntroductionGlobally, many young women face the overlapping burden of HIV infection and unintended pregnancy. Protection against both may benefit from safe and effective multipurpose prevention technologies.MethodsHealthy women ages 18–34 years, no
Externí odkaz:
https://doaj.org/article/5c0798227a72433685820cec538beb32
Autor:
Katya B. Rubinow, Guo Zhong, Lindsay C. Czuba, Judy Y. Chen, Estell Williams, Zoe Parr, Saurabh Khandelwal, Daniel Kim, Jeffrey LaFrance, Nina Isoherranen
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 6, Pp 1460-1471 (2022)
Abstract The prevalence of obesity continues to rise, underscoring the need to better understand the pathways mediating adipose tissue (AT) expansion. All‐trans‐retinoic acid (atRA), a bioactive vitamin A metabolite, regulates adipogenesis and en
Externí odkaz:
https://doaj.org/article/6a1c98368b2343359512d3cad592a6e2
Autor:
Luke F. Enthoven, Yuanyuan Shi, Emily Fay, Agnes Kim, Sue Moreni, Jennie Mao, Nina Isoherranen, Rheem A. Totah, Mary F. Hebert
Publikováno v:
Metabolites, Vol 13, Iss 9, p 1026 (2023)
Changes in the maternal metabolome, and specifically the maternal lipidome, that occur during pregnancy are relatively unknown. The objective of this investigation was to evaluate the effects of pregnancy on sphingolipid levels using metabolomics ana
Externí odkaz:
https://doaj.org/article/2b152150a8d04e66854961a42dd97875
Autor:
Hyunyoung Jeong, Abigail T. Armstrong, Nina Isoherranen, Lindsay Czuba, Amy Yang, Katelynn Zumpf, Jody Ciolino, Elizabeth Torres, Catherine S. Stika, Katherine L. Wisner
Publikováno v:
PLoS ONE, Vol 18, Iss 2 (2023)
Retinoids and vitamin A are essential for multiple biological functions, including vision and immune responses, as well as the development of an embryo during pregnancy. Despite its importance, alterations in retinoid homeostasis during normal human
Externí odkaz:
https://doaj.org/article/1caa64759478444cb9285f24e77d30ba
Autor:
Tomoki Imaoka, Weize Huang, Sara Shum, Dale W. Hailey, Shih-Yu Chang, Alenka Chapron, Catherine K. Yeung, Jonathan Himmelfarb, Nina Isoherranen, Edward J. Kelly
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Opioid overdose, dependence, and addiction are a major public health crisis. Patients with chronic kidney disease (CKD) are at high risk of opioid overdose, therefore novel methods that provide accurate prediction of renal clearance (CLr) an
Externí odkaz:
https://doaj.org/article/db5ac2fbd58248ce8a1251ee6b9e7c7a
Autor:
Daphney Jean, Kunal Naik, Lauren Milligan, Stephen Hall, Shiew Mei Huang, Nina Isoherranen, Colleen Kuemmel, Paul Seo, Million A. Tegenge, Yaning Wang, Yuching Yang, Xinyuan Zhang, Liang Zhao, Ping Zhao, Jessica Benjamin, Kimberly Bergman, Joseph Grillo, Rajanikanth Madabushi, Fang Wu, Hao Zhu, Issam Zineh
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 11, Pp 1271-1275 (2021)
Externí odkaz:
https://doaj.org/article/857bb5cce86240bba8f4309aa783564a
Autor:
Hongbing Wang, Paul C. Brown, Edwin C.Y. Chow, Lorna Ewart, Stephen S. Ferguson, Suzanne Fitzpatrick, Benjamin S. Freedman, Grace L. Guo, William Hedrich, Scott Heyward, James Hickman, Nina Isoherranen, Albert P. Li, Qi Liu, Shannon M. Mumenthaler, James Polli, William R. Proctor, Alexandre Ribeiro, Jian‐Ying Wang, Ronald L. Wange, Shiew‐Mei Huang
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 5, Pp 1659-1680 (2021)
Abstract Nonclinical testing has served as a foundation for evaluating potential risks and effectiveness of investigational new drugs in humans. However, the current two‐dimensional (2D) in vitro cell culture systems cannot accurately depict and si
Externí odkaz:
https://doaj.org/article/523a044f71fe468699fe3793345748a3
Autor:
Lindsay C. Czuba, Xia Wu, Weize Huang, Nicole Hollingshead, Jessica B. Roberto, Heidi L. Kenerson, Raymond S. Yeung, Ian N. Crispe, Nina Isoherranen
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 3, Pp 976-989 (2021)
Abstract All‐trans‐retinoic acid (atRA), the active metabolite of vitamin A, has antifibrogenic properties in vitro and in animal models. Liver vitamin A homeostasis is maintained by cell‐specific enzymatic activities including storage in hepat
Externí odkaz:
https://doaj.org/article/34b049063fdf462bbd6d0416bfd3488f