Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Nina Hedemann"'
Autor:
Jan Schadeck, Hans-Heinrich Oberg, Matthias Peipp, Nina Hedemann, Wolfgang W. Schamel, Dirk Bauerschlag, Daniela Wesch
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Ovarian carcinomas have the highest lethality amongst gynecological tumors. A problem after primary resection is the recurrence of epithelial ovarian carcinomas which is often associated with chemotherapy resistance. To improve the clinical outcome,
Externí odkaz:
https://doaj.org/article/c89fa082aacd4922b79cf97421138025
Autor:
Amelie Limburg, Xueqian Qian, Bernice Brechtefeld, Nina Hedemann, Inken Flörkemeier, Christoph Rogmans, Leticia Oliveira-Ferrer, Nicolai Maass, Norbert Arnold, Dirk O. Bauerschlag, Jörg Paul Weimer
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1171 (2024)
Examinations of ovarian cancer cells require the ability to identify tumor cells. Array-based comparative genome hybridization (aCGH) on 30 ovarian carcinomas (OC) identified three genomic loci (8q24.23; 17p12; 18q22.3) over- or under-represented in
Externí odkaz:
https://doaj.org/article/8d8eff3e1e8741f2b322bb36731c4e4b
Autor:
Junxue Dong, David Holthaus, Christian Peters, Stefanie Koster, Marzieh Ehsani, Alvaro Quevedo-Olmos, Hilmar Berger, Michal Zarobkiewicz, Mandy Mangler, Rajendra Kumar Gurumurthy, Nina Hedemann, Cindrilla Chumduri, Dieter Kabelitz, Thomas F. Meyer
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Cervical cancer is a leading cause of death among women globally, primarily driven by high-risk papillomaviruses. However, the effectiveness of chemotherapy is limited, underscoring the potential of personalized immunotherapies. Patient-derived organ
Externí odkaz:
https://doaj.org/article/22cb8b5291094598b7ec152c0b00f6f2
Autor:
Svetlana Magadeeva, Xueqian Qian, Nadine Korff, Inken Flörkemeier, Nina Hedemann, Christoph Rogmans, Michael Forster, Norbert Arnold, Nicolai Maass, Dirk O. Bauerschlag, Jörg P. Weimer
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17467 (2023)
Ovarian cancer (OC) cells with homologous recombination deficiency (HRD) accumulate genomic scars (LST, TAI, and LOH) over a value of 42 in sum. PARP inhibitors can treat OC with HRD. The detection of HRD can be done directly by imaging these genomic
Externí odkaz:
https://doaj.org/article/fdc7e9c5dd0944aeba619a6ce87f533b
Autor:
Gerrit Hugendieck, Marcus Lettau, Svenja Andreas, Sabrina Neumann, Natalie Reinhardt, Philipp Arnold, Franziska Theilig, Lorenz Bastian, Christoph Rogmans, Jörg P. Weimer, Inken Flörkemeier, Daniela Wesch, Norbert Arnold, Nicolai Maass, Ottmar Janssen, Dirk Bauerschlag, Nina Hedemann
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 7, Pp n/a-n/a (2023)
Abstract Ovarian cancer (OvCa) is the gynaecological disorder with the poorest prognosis due to the fast development of chemoresistance. We sought to connect chemoresistance and cancer cell‐derived extracellular vesicles (EV). The mechanisms of how
Externí odkaz:
https://doaj.org/article/b608a4f57c4247b186f7a69bb4075f92
Autor:
Inken Flörkemeier, Tamara N. Steinhauer, Nina Hedemann, Magnus Ölander, Per Artursson, Bernd Clement, Dirk O. Bauerschlag
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 13 (2021)
Background: Ovarian cancer (OvCa) constitutes a rare and highly aggressive malignancy and is one of the most lethal of all gynaecologic neoplasms. Due to chemotherapy resistance and treatment limitations because of side effects, OvCa is still not suf
Externí odkaz:
https://doaj.org/article/8b89334405764c299bc1e0e335c0f7dc
Autor:
Christoph Rogmans, Julia Feuerborn, Leonie Treeck, Nils Tribian, Inken Flörkemeier, Norbert Arnold, Jörg Paul Weimer, Nicolai Maass, Peer Jansen, Wolfgang Lieb, Astrid Dempfle, Dirk O. Bauerschlag, Nina Hedemann
Publikováno v:
Cancers, Vol 14, Iss 23, p 5867 (2022)
Ovarian cancer is the third most common gynecological malignancy and has the highest mortality rate. Owing to unspecific symptoms, ovarian cancer is not detected until an advanced stage in about two-thirds of cases. Therefore, it is crucial to establ
Externí odkaz:
https://doaj.org/article/7d27bcd0b33b4e718bb5b49566379b58
Autor:
Inken Flörkemeier, Julia S. Hillmann, Jörg P. Weimer, Jonas Hildebrandt, Nina Hedemann, Christoph Rogmans, Astrid Dempfle, Norbert Arnold, Bernd Clement, Dirk O. Bauerschlag
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10503 (2022)
Although ovarian cancer is a rare disease, it constitutes the fifth leading cause of cancer death among women. It is of major importance to develop new therapeutic strategies to improve survival. Combining P8-D6, a novel dual topoisomerase inhibitor
Externí odkaz:
https://doaj.org/article/cbc4941eeda342ef9dba2e8142325f8d
Autor:
Miryam Müller, Claire Saunders, Anke Senftleben, Johannes P. W. Heidbuechel, Birgit Halwachs, Julia Bolik, Nina Hedemann, Christian Röder, Dirk Bauerschlag, Stefan Rose-John, Dirk Schmidt-Arras
Publikováno v:
Cells, Vol 11, Iss 17, p 2683 (2022)
Ectodomain shedding is an irreversible process to regulate inter- and intracellular signaling. Members of the a disintegrin and metalloprotease (ADAM) family are major mediators of ectodomain shedding. ADAM17 is involved in the processing of multiple
Externí odkaz:
https://doaj.org/article/a9ea442961a64afa94499ce585b8ac1d
Autor:
Inken Flörkemeier, Tamara N. Steinhauer, Nina Hedemann, Jörg Paul Weimer, Christoph Rogmans, Marion T. van Mackelenbergh, Nicolai Maass, Bernd Clement, Dirk O. Bauerschlag
Publikováno v:
Cancers, Vol 14, Iss 1, p 2 (2021)
Breast cancer constitutes the leading cause of cancer deaths among females. However, numerous shortcomings, including low bioavailability, resistance and significant side effects, are responsible for insufficient treatment. The ultimate goal, therefo
Externí odkaz:
https://doaj.org/article/f066b75d3e2d4f689baa009ea00ce786