Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Nina Hedemann"'
Autor:
Inken Flörkemeier, Lisa K. Antons, Jörg P. Weimer, Nina Hedemann, Christoph Rogmans, Sandra Krüger, Regina Scherließ, Astrid Dempfle, Norbert Arnold, Nicolai Maass, Dirk O. Bauerschlag
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract In vitro, spheroid models have become well established in cancer research because they can better mimic certain characteristics of in vivo tumours. However, interaction with the tumour microenvironment, such as cancer-associated fibroblasts,
Externí odkaz:
https://doaj.org/article/64babe67f1b14d97a499efdf4b30fa15
Inhibition of ADAM17 increases the cytotoxic effect of cisplatin in cervical spheroids and organoids
Autor:
David Holthaus, Christoph Rogmans, Ina Gursinski, Alvaro Quevedo-Olmos, Marzieh Ehsani, Mandy Mangler, Inken Flörkemeier, Jörg P. Weimer, Thomas F. Meyer, Nicolai Maass, Dirk O. Bauerschlag, Nina Hedemann
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionCervical cancer represents one of the main causes of female, cancer-related mortality worldwide. The majority of cancers are caused by human papillomaviruses such as HPV16 and HPV18. As chemotherapeutic resistance to first-line platinum t
Externí odkaz:
https://doaj.org/article/03b213b6b8984864bcfc1799a85cfa7e
Autor:
Amelie Limburg, Xueqian Qian, Bernice Brechtefeld, Nina Hedemann, Inken Flörkemeier, Christoph Rogmans, Leticia Oliveira-Ferrer, Nicolai Maass, Norbert Arnold, Dirk O. Bauerschlag, Jörg Paul Weimer
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1171 (2024)
Examinations of ovarian cancer cells require the ability to identify tumor cells. Array-based comparative genome hybridization (aCGH) on 30 ovarian carcinomas (OC) identified three genomic loci (8q24.23; 17p12; 18q22.3) over- or under-represented in
Externí odkaz:
https://doaj.org/article/8d8eff3e1e8741f2b322bb36731c4e4b
Autor:
Jan Schadeck, Hans-Heinrich Oberg, Matthias Peipp, Nina Hedemann, Wolfgang W. Schamel, Dirk Bauerschlag, Daniela Wesch
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Ovarian carcinomas have the highest lethality amongst gynecological tumors. A problem after primary resection is the recurrence of epithelial ovarian carcinomas which is often associated with chemotherapy resistance. To improve the clinical outcome,
Externí odkaz:
https://doaj.org/article/c89fa082aacd4922b79cf97421138025
Autor:
Junxue Dong, David Holthaus, Christian Peters, Stefanie Koster, Marzieh Ehsani, Alvaro Quevedo-Olmos, Hilmar Berger, Michal Zarobkiewicz, Mandy Mangler, Rajendra Kumar Gurumurthy, Nina Hedemann, Cindrilla Chumduri, Dieter Kabelitz, Thomas F. Meyer
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Cervical cancer is a leading cause of death among women globally, primarily driven by high-risk papillomaviruses. However, the effectiveness of chemotherapy is limited, underscoring the potential of personalized immunotherapies. Patient-derived organ
Externí odkaz:
https://doaj.org/article/22cb8b5291094598b7ec152c0b00f6f2
Autor:
Gerrit Hugendieck, Marcus Lettau, Svenja Andreas, Sabrina Neumann, Natalie Reinhardt, Philipp Arnold, Franziska Theilig, Lorenz Bastian, Christoph Rogmans, Jörg P. Weimer, Inken Flörkemeier, Daniela Wesch, Norbert Arnold, Nicolai Maass, Ottmar Janssen, Dirk Bauerschlag, Nina Hedemann
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 7, Pp n/a-n/a (2023)
Abstract Ovarian cancer (OvCa) is the gynaecological disorder with the poorest prognosis due to the fast development of chemoresistance. We sought to connect chemoresistance and cancer cell‐derived extracellular vesicles (EV). The mechanisms of how
Externí odkaz:
https://doaj.org/article/b608a4f57c4247b186f7a69bb4075f92
Autor:
Svetlana Magadeeva, Xueqian Qian, Nadine Korff, Inken Flörkemeier, Nina Hedemann, Christoph Rogmans, Michael Forster, Norbert Arnold, Nicolai Maass, Dirk O. Bauerschlag, Jörg P. Weimer
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17467 (2023)
Ovarian cancer (OC) cells with homologous recombination deficiency (HRD) accumulate genomic scars (LST, TAI, and LOH) over a value of 42 in sum. PARP inhibitors can treat OC with HRD. The detection of HRD can be done directly by imaging these genomic
Externí odkaz:
https://doaj.org/article/fdc7e9c5dd0944aeba619a6ce87f533b
Autor:
Nina Hedemann, Alexander Thomas, Nils Tribian, Lutz Kloke, Dirk Bauerschlag, Marion van Mackelenbergh
Publikováno v:
Cancer Research. 83:P2-15
Although multi-modal and ablative treatment strategies for breast cancer are becoming more popular, partial or full mastectomy is still a most common intervention. While proving to be effective in curing the cancer, it leaves the patient disfigured,
Autor:
Inken Flörkemeier, Tamara N. Steinhauer, Nina Hedemann, Magnus Ölander, Per Artursson, Bernd Clement, Dirk O. Bauerschlag
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 13 (2021)
Background: Ovarian cancer (OvCa) constitutes a rare and highly aggressive malignancy and is one of the most lethal of all gynaecologic neoplasms. Due to chemotherapy resistance and treatment limitations because of side effects, OvCa is still not suf
Externí odkaz:
https://doaj.org/article/8b89334405764c299bc1e0e335c0f7dc
Autor:
Inken Flörkemeier, Julia S. Hillmann, Jörg P. Weimer, Jonas Hildebrandt, Nina Hedemann, Christoph Rogmans, Astrid Dempfle, Norbert Arnold, Bernd Clement, Dirk O. Bauerschlag
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10503 (2022)
Although ovarian cancer is a rare disease, it constitutes the fifth leading cause of cancer death among women. It is of major importance to develop new therapeutic strategies to improve survival. Combining P8-D6, a novel dual topoisomerase inhibitor
Externí odkaz:
https://doaj.org/article/cbc4941eeda342ef9dba2e8142325f8d