Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Nina G. Dolinnaya"'
Autor:
Viktoriia Yu. Savitskaya, Nina G. Dolinnaya, Vadim V. Strekalovskikh, Elizaveta S. Peskovatskova, Viktoriia G. Snyga, Vadim S. Trefilov, Mayya V. Monakhova, Elena A. Kubareva
Publikováno v:
Medical Sciences, Vol 11, Iss 4, p 76 (2023)
Neisseria meningitidis (N. meningitidis) serogroup B (MenB) is the leading cause of invasive meningococcal disease worldwide. The pathogen has a wide range of virulence factors, which are potential vaccine components. Studying the genetic variability
Externí odkaz:
https://doaj.org/article/716bc0085bec41a4b5d9f325e81e5d3c
Autor:
Alexander V. Sergeev, Andrei G. Loiko, Adelya I. Genatullina, Alexander S. Petrov, Elena A. Kubareva, Nina G. Dolinnaya, Elizaveta S. Gromova
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 45 (2023)
The methylation of cytosines at CpG sites in DNA, carried out de novo by DNA methyltransferase Dnmt3a, is a basic epigenetic modification involved in gene regulation and genome stability. Aberrant CpG methylation in gene promoters leads to oncogenesi
Externí odkaz:
https://doaj.org/article/d0f8d4fe09894ec6bf4ced09adabb6f7
Autor:
Vera V. Panova, Nina G. Dolinnaya, Kirill A. Novoselov, Viktoriia Yu. Savitskaya, Ivan S. Chernykh, Elena A. Kubareva, Andrei V. Alexeevski, Maria I. Zvereva
Publikováno v:
Life, Vol 13, Iss 7, p 1478 (2023)
Somatic mutations in the promoter region of the human telomerase reverse transcriptase (hTERT) gene have been identified in many types of cancer. The hTERT promoter is known to be enriched with sequences that enable the formation of G-quadruplex (G4)
Externí odkaz:
https://doaj.org/article/e6384f376c0c4bdfa718f9cf6bcde5e0
Autor:
Viktoriia Yu. Savitskaya, Vadim V. Strekalovskikh, Viktoriia G. Snyga, Mayya V. Monakhova, Alexander M. Arutyunyan, Nina G. Dolinnaya, Elena A. Kubareva
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6167 (2023)
The human pathogen Neisseria gonorrhoeae uses a homologous recombination to undergo antigenic variation and avoid an immune response. The surface protein pilin (PilE) is one of the targets for antigenic variation that can be regulated by N. gonorrhoe
Externí odkaz:
https://doaj.org/article/648604459bf847b89b394fff83678ccf
Autor:
Anzhela V. Pavlova, Nina G. Dolinnaya, Maria I. Zvereva, Elena A. Kubareva, Mayya V. Monakhova
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1061 (2023)
G-quadruplexes (G4s), the most widely studied alternative DNA structures, are implicated in the regulation of the key cellular processes. In recent years, their involvement in DNA repair machinery has become the subject of intense research. Here, we
Externí odkaz:
https://doaj.org/article/94f06d6ad4704050bf6b3cadd6d4e9d0
Impact of G-Quadruplex Structures on Methylation of Model Substrates by DNA Methyltransferase Dnmt3a
Autor:
Andrei G. Loiko, Alexander V. Sergeev, Adelya I. Genatullina, Mayya V. Monakhova, Elena A. Kubareva, Nina G. Dolinnaya, Elizaveta S. Gromova
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10226 (2022)
In mammals, de novo methylation of cytosines in DNA CpG sites is performed by DNA methyltransferase Dnmt3a. Changes in the methylation status of CpG islands are critical for gene regulation and for the progression of some cancers. Recently, the poten
Externí odkaz:
https://doaj.org/article/87c1cb17538547ab8ab49d40424593c1
Autor:
Anzhela V. Pavlova, Victoria Yu. Savitskaya, Nina G. Dolinnaya, Mayya V. Monakhova, Anastasia V. Litvinova, Elena A. Kubareva, Maria I. Zvereva
Publikováno v:
Biomedicines, Vol 10, Iss 8, p 1871 (2022)
G-quadruplexes (G4s) are a unique class of noncanonical DNAs that play a key role in cellular processes and neoplastic transformation. Herein, we focused on the promoter region of human TERT oncogene, whose product is responsible for the immortality
Externí odkaz:
https://doaj.org/article/ea5ae07ea1ef4a8f97a2c329e048a38f
Autor:
Roman G. Zenkov, Kirill I. Kirsanov, Anna M. Ogloblina, Olga A. Vlasova, Denis S. Naberezhnov, Natalia Y. Karpechenko, Timur I. Fetisov, Ekaterina A. Lesovaya, Gennady A. Belitsky, Nina G. Dolinnaya, Marianna G. Yakubovskaya
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 9209 (2022)
Guanine-rich DNA sequences tending to adopt noncanonical G-quadruplex (G4) structures are over-represented in promoter regions of oncogenes. Ligands recognizing G4 were shown to stabilize these DNA structures and drive their formation regulating expr
Externí odkaz:
https://doaj.org/article/05a632071b7f4dbd854e17254fbf3481
Autor:
Anzhela V. Pavlova, Elena A. Kubareva, Mayya V. Monakhova, Maria I. Zvereva, Nina G. Dolinnaya
Publikováno v:
Biomolecules, Vol 11, Iss 9, p 1284 (2021)
DNA G-quadruplexes (G4s) are known to be an integral part of the complex regulatory systems in both normal and pathological cells. At the same time, the ability of G4s to impede DNA replication plays a critical role in genome integrity. This review s
Externí odkaz:
https://doaj.org/article/31581047bcb8426c8ab987ec712e2f66
Autor:
Ekaterina A. Golenkina, Svetlana I. Galkina, Nina G. Dolinnaya, Evgenii A. Arifulin, Yulia M. Romanova, Galina F. Sud’ina
Publikováno v:
Pathogens, Vol 10, Iss 5, p 530 (2021)
Mimicking bacterial DNA, synthetic CpG-containing oligodeoxyribonucleotides (CpG-ODNs) have a powerful immunomodulatory potential. Their practical application is mainly associated with the production of vaccines, where they are used as adjuvants, as
Externí odkaz:
https://doaj.org/article/64165e0383a040f2b3825202cc29ced1