Studying the Fate of Tumor Extracellular Vesicles at High Spatiotemporal Resolution Using the Zebrafish Embryo

Autor: Jack Bauer, Benjamin Mary, Christine Carapito, Vincent Hyenne, Luc Mercier, Joanna Bons, François Delalande, Susana Garcia Silva, Frederik J. Verweij, Ana Amor López, Héctor Peinado, Jacky G. Goetz, Nina Fekonja, Mayeul Collot, Sébastien Harlepp, Farida Djouad, Andrey S. Klymchenko, Ignacio Busnelli, Olivier Lefebvre, Maria Jesus Garcia-Leon, Pedro Machado, Shima Ghoroghi, Guillaume van Niel, Gautier Follain

Publikováno v: Developmental Cell
Developmental Cell, Elsevier, 2019, 48 (4), pp.554-572.e7. ⟨10.1016/j.devcel.2019.01.014⟩

International audience; Tumor extracellular vesicles (EVs) mediate the communication between tumor and stromal cells mostly to the benefit of tumor progression. Notably, tumor EVs travel in the bloodstream, reach distant organs, and locally modify th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::687322edc9a405f51ac892ac9b3c93fc
https://hal.archives-ouvertes.fr/hal-02274251/document

An Arf6- and caveolae-dependent pathway links hemidesmosome remodeling and mechanoresponse

Autor: Julien Pontabry, Nina Fekonja, Naël Osmani, Michel Labouesse, Jacky G. Goetz, Elisabeth Georges-Labouesse, Daniel Riveline, Jordi Comelles

Publikováno v: Molecular Biology of the Cell
Molecular Biology of the Cell, American Society for Cell Biology, 2018, 29 (4), pp.435-451. ⟨10.1091/mbc.E17-06-0356⟩
Molecular Biology of the Cell, 2018, 29 (4), pp.435-451. ⟨10.1091/mbc.E17-06-0356⟩

International audience; Hemidesmosomes (HDs) are epithelial-specific cell-matrix adhesions that stably anchor the intracellular keratin network to the extracellular matrix. Although their main role is to protect the epithelial sheet from external mec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c5abaa6108226014ad52238f1144081
https://hal.archives-ouvertes.fr/hal-02398877

Hemodynamic Forces Tune the Arrest, Adhesion, and Extravasation of Circulating Tumor Cells

Autor: André Kemmling, Markus Glatzel, Klaus Pantel, Jacky G. Goetz, Nina Fekonja, Frank Winkler, Guillaume Dollé, Matthia A. Karreman, Claudia Hille, Susanne Siemonsen, Luc Mercier, Nicodème Paul, Gautier Follain, Vincent Chabannes, Yannick Schwab, Marìa Jesùs Garcia Leòn, Christophe Prud'Homme, François Der Hovsepian, Guillaume Allio, Gergely Solecki, Jens Fiehler, Raphael Carapito, Thibaut Metivet, Naël Osmani, Angélique Pichot, Tanja Schneider, Ana Sofia Azevedo, Siamak Bahram, Sébastien Harlepp, Bernhard Ruthensteiner, Olivier Lefebvre

Publikováno v: Developmental Cell
Developmental Cell, Elsevier, In press, ⟨10.1101/183046⟩
Developmental Cell, Elsevier, 2018, 45 (1), ⟨10.1016/j.devcel.2018.02.015⟩
Developmental Cell, Elsevier, 2018, 45 (1), pp.33-52.e12. ⟨10.1016/j.devcel.2018.02.015⟩

Metastatic seeding is driven by cell-intrinsic and environmental cues, yet the contribution of biomechanics is poorly known. We aim to elucidate the impact of blood flow on the arrest and the extravasation of circulating tumor cells (CTCs) in vivo. U

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b6d1c376616b5a94e9aba86399b836
https://doi.org/10.1016/j.devcel.2018.02.015

In vivo imaging of skeletal muscle in mice highlights muscle defects in a model of myotubular myopathy

Autor: Johann Böhm, Nina Fekonja, Marc Koch, Jocelyn Laporte, Guillaume Allio, Yves Lutz, Luc Mercier, Jacky G. Goetz

Publikováno v: IntraVital. 5:e1168553

Skeletal muscle structure and function are altered in different myopathies. However, the understanding of the molecular and cellular mechanisms mainly rely on in vitro and ex vivo investigations in mammalian models. In order to monitor in vivo the in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3700ff5f87c2b97745e22e1d9d7d5f50
https://doi.org/10.1080/21659087.2016.1168553