Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Nina F. Øbro"'
Autor:
Heather E. Machado, Nina F. Øbro, Nicholas Williams, Shengjiang Tan, Ahmed Z. Boukerrou, Megan Davies, Miriam Belmonte, Emily Mitchell, E. Joanna Baxter, Nicole Mende, Anna Clay, Philip Ancliff, Jutta Köglmeier, Sally B. Killick, Austin Kulasekararaj, Stefan Meyer, Elisa Laurenti, Peter J. Campbell, David G. Kent, Jyoti Nangalia, Alan J. Warren
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Clonal tracking of cells using somatic mutations permits exploration of clonal dynamics in human disease. Here, we perform whole genome sequencing of 323 haematopoietic colonies from 10 individuals with the inherited ribosomopathy Shwachman-
Externí odkaz:
https://doaj.org/article/83d4535580c848179ab239f1596e4673
Publikováno v:
HemaSphere, Vol 4, Iss 6, p e491 (2020)
Externí odkaz:
https://doaj.org/article/c5737080b50540ae84fd208812a0a92a
Autor:
Nina F. Øbro, Jacob Grinfeld, Miriam Belmonte, Melissa Irvine, Mairi S. Shepherd, Tata Nageswara Rao, Axel Karow, Lisa M. Riedel, Oliva B. Harris, E. Joanna Baxter, Jyoti Nangalia, Anna Godfrey, Claire N. Harrison, Juan Li, Radek C. Skoda, Peter J. Campbell, Anthony R. Green, David G. Kent
Publikováno v:
HemaSphere, Vol 4, Iss 3, p e371 (2020)
Abstract. Myeloproliferative neoplasms (MPNs) are characterized by deregulation of mature blood cell production and increased risk of myelofibrosis (MF) and leukemic transformation. Numerous driver mutations have been identified but substantial disea
Externí odkaz:
https://doaj.org/article/43e4a632d24a477996c58eecfcde097c
Autor:
Nina F. Øbro, Lars P. Ryder, Hans O. Madsen, Mette K. Andersen, Birgitte Lausen, Henrik Hasle, Kjeld Schmiegelow, Hanne V. Marquart
Publikováno v:
Haematologica, Vol 97, Iss 1 (2012)
Reduction in minimal residual disease, measured by real-time quantitative PCR or flow cytometry, predicts prognosis in childhood B-cell precursor acute lymphoblastic leukemia. We explored whether cells reported as minimal residual disease by flow cyt
Externí odkaz:
https://doaj.org/article/9e969df292fa429f8a51d1f92167da47
Autor:
Christopher J.A. Duncan, Morten K. Skouboe, Sophie Howarth, Anne K. Hollensen, Rui Chen, Malene L. Børresen, Benjamin J. Thompson, Jarmila Stremenova Spegarova, Catherine F. Hatton, Frederik F. Stæger, Mette K. Andersen, John Whittaker, Søren R. Paludan, Sofie E. Jørgensen, Martin K. Thomsen, Jacob G. Mikkelsen, Carsten Heilmann, Daniela Buhas, Nina F. Øbro, Jakob T. Bay, Hanne V. Marquart, M. Teresa de la Morena, Joseph A. Klejka, Matthew Hirschfeld, Line Borgwardt, Isabel Forss, Tania Masmas, Anja Poulsen, Francisco Noya, Guy Rouleau, Torben Hansen, Sirui Zhou, Anders Albrechtsen, Reza Alizadehfar, Eric J. Allenspach, Sophie Hambleton, Trine H. Mogensen
Publikováno v:
Duncan, C J A, Skouboe, M K, Howarth, S, Hollensen, A K, Chen, R, Børresen, M L, Thompson, B J, Spegarova, J S, Hatton, C F, Stæger, F F, Andersen, M K, Whittaker, J, Paludan, S R, Jørgensen, S E, Thomsen, M K, Mikkelsen, J G, Heilmann, C, Buhas, D, Øbro, N F, Bay, J T, Marquart, H V, Morena, M T D L, Klejka, J A, Hirschfeld, M, Borgwardt, L, Forss, I, Masmas, T, Poulsen, A, Noya, F, Rouleau, G, Hansen, T, Zhou, S, Albrechtsen, A, Alizadehfar, R, Allenspach, E J, Hambleton, S & Mogensen, T H 2022, ' Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic ', Journal of Experimental Medicine, vol. 219, no. 6, e20212427 . https://doi.org/10.1084/jem.20212427
Duncan, C J A, Skouboe, M K, Howarth, S, Hollensen, A K, Chen, R, Børresen, M L, Thompson, B J, Stremenova Spegarova, J, Hatton, C F, Stæger, F F, Andersen, M K, Whittaker, J, Paludan, S R, Jørgensen, S E, Thomsen, M K, Mikkelsen, J G, Heilmann, C, Buhas, D, Øbro, N F, Bay, J T, Marquart, H V, de la Morena, M T, Klejka, J A, Hirschfeld, M, Borgwardt, L, Forss, I, Masmas, T, Poulsen, A, Noya, F, Rouleau, G, Hansen, T, Zhou, S, Albrechtsen, A, Alizadehfar, R, Allenspach, E J, Hambleton, S & Mogensen, T H 2022, ' Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic ', The Journal of Experimental Medicine, vol. 219, no. 6, e20212427 . https://doi.org/10.1084/jem.20212427
Duncan, C J A, Skouboe, M K, Howarth, S, Hollensen, A K, Chen, R, Børresen, M L, Thompson, B J, Stremenova Spegarova, J, Hatton, C F, Stæger, F F, Andersen, M K, Whittaker, J, Paludan, S R, Jørgensen, S E, Thomsen, M K, Mikkelsen, J G, Heilmann, C, Buhas, D, Øbro, N F, Bay, J T, Marquart, H V, de la Morena, M T, Klejka, J A, Hirschfeld, M, Borgwardt, L, Forss, I, Masmas, T, Poulsen, A, Noya, F, Rouleau, G, Hansen, T, Zhou, S, Albrechtsen, A, Alizadehfar, R, Allenspach, E J, Hambleton, S & Mogensen, T H 2022, ' Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic ', The Journal of Experimental Medicine, vol. 219, no. 6, e20212427 . https://doi.org/10.1084/jem.20212427
Type I interferons (IFN-I) play a critical role in human antiviral immunity, as demonstrated by the exceptionally rare deleterious variants of IFNAR1 or IFNAR2. We investigated five children from Greenland, Canada, and Alaska presenting with viral di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e0e93df69405efb9dfa8932bb4d0da2
https://curis.ku.dk/portal/da/publications/lifethreatening-viral-disease-in-a-novel-form-of-autosomal-recessive-ifnar2-deficiency-in-the-arctic(38e5d906-7ed0-4521-981d-02d7dbdab48d).html
https://curis.ku.dk/portal/da/publications/lifethreatening-viral-disease-in-a-novel-form-of-autosomal-recessive-ifnar2-deficiency-in-the-arctic(38e5d906-7ed0-4521-981d-02d7dbdab48d).html
Autor:
Francesco Maura, Michael Davies, Miriam Belmonte, Alex Cagan, Craig McDonald, Robert J. Osborne, Mairi Shepherd, Peter J. Campbell, Emily G. Mitchell, Daniel Leongamornlert, Andrew Green, K Kübler, Kourosh Saeb-Parsy, Elisa Laurenti, Heather E. Machado, Inigo Martincorena, David G. Kent, Mathijs A. Sanders, Gad Getz, Daniel J. Hodson, Nina F. Øbro, Krishnaa T. Mahbubani, Paz Polak
A lymphocyte suffers many threats to its genome, including programmed mutation during differentiation, antigen-driven proliferation and residency in diverse microenvironments. After developing protocols for single-cell lymphocyte expansions, we seque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd4b87c00090a2a777e88893f0c3c79b
https://doi.org/10.1101/2021.04.29.441939
https://doi.org/10.1101/2021.04.29.441939
Autor:
Michael R. Stratton, Krishnaa T. Mahubani, Raheleh Rahbari, Sigurgeir Olafsson, Kourosh Saeb-Parsy, Emily G. Mitchell, Eugene Jing Kwa, Alex Cagan, David G. Kent, Heather E. Machado, Robert J. Osborne, David T. Jones, Peter J. Campbell, Andrew Russell, Michael Spencer Chapman, Elisa Laurenti, Tim H. H. Coorens, Megan Davies, Yichen Wang, Steven Leonard, Henry Lee-Six, Nina F. Øbro, Adrian Baez-Ortega, Peter R. Ellis, Luke M. R. Harvey, Kieren Allinson, Stefanie V Lensing, Andrew R. J. Lawson, Moritz Gerstung, Federico Abascal, Raul E. Alcantara, Inigo Martincorena
Publikováno v:
Nature
Cell Res
Cell Res
Somatic mutations drive the development of cancer and may contribute to ageing and other diseases1,2. Despite their importance, the difficulty of detecting mutations that are only present in single cells or small clones has limited our knowledge of s
Publikováno v:
HemaSphere
HemaSphere, Vol 4, Iss 6, p e491 (2020)
HemaSphere, Vol 4, Iss 6, p e491 (2020)
Autor:
David G. Kent, Lisa M Riedel, E. Joanna Baxter, Tata Nageswara Rao, Oliva B Harris, Jyoti Nangalia, Jacob Grinfeld, Juan Li, Radek C. Skoda, Mairi Shepherd, Miriam Belmonte, Anthony R. Green, Anna L. Godfrey, Claire N. Harrison, Peter J. Campbell, Axel Karow, Melissa Irvine, Nina F. Øbro
Publikováno v:
HemaSphere
HemaSphere, Vol 4, Iss 3, p e371 (2020)
HemaSphere, Vol 4, Iss 3, p e371 (2020)
Myeloproliferative neoplasms (MPNs) are characterized by deregulation of mature blood cell production and increased risk of myelofibrosis (MF) and leukemic transformation. Numerous driver mutations have been identified but substantial disease heterog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c9ccdb45e00821fe0b99e8657f4fc8
Autor:
Elisa Laurenti, Anthony R. Green, Michael R. Stratton, Nina F. Øbro, Mairi Shepherd, Henry Lee-Six, Sebastian Grossmann, Kevin J. Dawson, Inigo Martincorena, David G. Kent, Robert J. Osborne, Peter J. Campbell, Brian J. P. Huntly, Laura O’Neill, Elizabeth Anderson, Miriam Belmonte
Publikováno v:
Nature
Haematopoietic stem cells drive blood production, but their population size and lifetime dynamics have not been quantified directly in humans. Here we identified 129,582 spontaneous, genome-wide somatic mutations in 140 single-cell-derived haematopoi