Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Nina F Gnädig"'
Autor:
Barbara H Stokes, Satish K Dhingra, Kelly Rubiano, Sachel Mok, Judith Straimer, Nina F Gnädig, Ioanna Deni, Kyra A Schindler, Jade R Bath, Kurt E Ward, Josefine Striepen, Tomas Yeo, Leila S Ross, Eric Legrand, Frédéric Ariey, Clark H Cunningham, Issa M Souleymane, Adama Gansané, Romaric Nzoumbou-Boko, Claudette Ndayikunda, Abdunoor M Kabanywanyi, Aline Uwimana, Samuel J Smith, Olimatou Kolley, Mathieu Ndounga, Marian Warsame, Rithea Leang, François Nosten, Timothy JC Anderson, Philip J Rosenthal, Didier Ménard, David A Fidock
Publikováno v:
eLife, Vol 10 (2021)
The emergence of mutant K13-mediated artemisinin (ART) resistance in Plasmodium falciparum malaria parasites has led to widespread treatment failures across Southeast Asia. In Africa, K13-propeller genotyping confirms the emergence of the R561H mutat
Externí odkaz:
https://doaj.org/article/3358baaa1cad40f3a6991b0106481a5a
Autor:
Nina F Gnädig, Barbara H Stokes, Rachel L Edwards, Gavreel F Kalantarov, Kim C Heimsch, Michal Kuderjavy, Audrey Crane, Marcus C S Lee, Judith Straimer, Katja Becker, Ilya N Trakht, Audrey R Odom John, Sachel Mok, David A Fidock
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008482 (2020)
The emergence of artemisinin (ART) resistance in Plasmodium falciparum intra-erythrocytic parasites has led to increasing treatment failure rates with first-line ART-based combination therapies in Southeast Asia. Decreased parasite susceptibility is
Externí odkaz:
https://doaj.org/article/63f0cf7a413247b28ca9b575fa65febb
Autor:
Stanislaw J Gabryszewski, Satish K Dhingra, Jill M Combrinck, Ian A Lewis, Paul S Callaghan, Matthew R Hassett, Amila Siriwardana, Philipp P Henrich, Andrew H Lee, Nina F Gnädig, Lise Musset, Manuel Llinás, Timothy J Egan, Paul D Roepe, David A Fidock
Publikováno v:
PLoS Pathogens, Vol 12, Iss 11, p e1005976 (2016)
Southeast Asia is an epicenter of multidrug-resistant Plasmodium falciparum strains. Selective pressures on the subcontinent have recurrently produced several allelic variants of parasite drug resistance genes, including the P. falciparum chloroquine
Externí odkaz:
https://doaj.org/article/bab670c229784bbdbbf53c730e617d2b
Autor:
Amélie Le Bihan, Ruben de Kanter, Iñigo Angulo-Barturen, Christoph Binkert, Christoph Boss, Reto Brun, Ralf Brunner, Stephan Buchmann, Jeremy Burrows, Koen J Dechering, Michael Delves, Sonja Ewerling, Santiago Ferrer, Christoph Fischli, Francisco Javier Gamo-Benito, Nina F Gnädig, Bibia Heidmann, María Belén Jiménez-Díaz, Didier Leroy, Maria Santos Martínez, Solange Meyer, Joerg J Moehrle, Caroline L Ng, Rintis Noviyanti, Andrea Ruecker, Laura María Sanz, Robert W Sauerwein, Christian Scheurer, Sarah Schleiferboeck, Robert Sinden, Christopher Snyder, Judith Straimer, Grennady Wirjanata, Jutta Marfurt, Ric N Price, Thomas Weller, Walter Fischli, David A Fidock, Martine Clozel, Sergio Wittlin
Publikováno v:
PLoS Medicine, Vol 13, Iss 10, p e1002138 (2016)
BackgroundArtemisinin resistance observed in Southeast Asia threatens the continued use of artemisinin-based combination therapy in endemic countries. Additionally, the diversity of chemical mode of action in the global portfolio of marketed antimala
Externí odkaz:
https://doaj.org/article/c760742987d34859b710bc8b89e29d3c
Autor:
Antonio V Bordería, Ofer Isakov, Gonzalo Moratorio, Rasmus Henningsson, Sonia Agüera-González, Lindsey Organtini, Nina F Gnädig, Hervé Blanc, Andrés Alcover, Susan Hafenstein, Magnus Fontes, Noam Shomron, Marco Vignuzzi
Publikováno v:
PLoS Pathogens, Vol 11, Iss 5, p e1004838 (2015)
Understanding how a pathogen colonizes and adapts to a new host environment is a primary aim in studying emerging infectious diseases. Adaptive mutations arise among the thousands of variants generated during RNA virus infection, and identifying thes
Externí odkaz:
https://doaj.org/article/12bf3c4d8949455489cae1b59f70dc80
Autor:
Laura I Levi, Nina F Gnädig, Stéphanie Beaucourt, Malia J McPherson, Bruno Baron, Jamie J Arnold, Marco Vignuzzi
Publikováno v:
PLoS Pathogens, Vol 6, Iss 10, p e1001163 (2010)
In a screen for RNA mutagen resistance, we isolated a high fidelity RNA dependent RNA polymerase (RdRp) variant of Coxsackie virus B3 (CVB3). Curiously, this variant A372V is also resistant to amiloride. We hypothesize that amiloride has a previously
Externí odkaz:
https://doaj.org/article/b8763665235e41dca5c8d5331893504c
Autor:
Sachel Mok, David A. Fidock, Barbara H. Stokes, Nina F. Gnädig, Chanaki Amaratunga, Zbynek Bozdech, Erik L. Allman, Andrew R. Bottrill, Jaishree Tripathi, Lev Solyakov, Tomas Yeo, Leila S. Ross, Manuel Llinás, Rick M. Fairhurst, Andrew B. Tobin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
The emergence and spread of artemisinin resistance, driven by mutations in Plasmodium falciparum K13, has compromised antimalarial efficacy and threatens the global malaria elimination campaign. By applying systems-based quantitative transcriptomics,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe06626fa6cba8e7742fa6fc309c6721
https://doaj.org/article/bc2f468af6fd4c64bd1c2706fa3f4ce6
https://doaj.org/article/bc2f468af6fd4c64bd1c2706fa3f4ce6
Autor:
Jennifer A. Yang, Bing Yu Zou, Frances Rocamora, Edgar Vigil, Prianka Kumar, Nina F. Gnädig, Alan F. Cowman, David A. Fidock, Roy Williams, Trevor Johnson, Madeline R. Luth, Danushka S. Marapana, Dylan Hutson, Marcus C. S. Lee, Tilla S. Worgall, Jianbo Huang, Gregory M. Goldgof, Gregory LaMonte, T. R. Santha Kumar, Jennifer K. Thompson, Timothy J. Egan, Roxanne Mohunlal, Sabine Ottilie, Dionicio Siegel, Elizabeth A. Winzeler, Andrea L. Cheung
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
A promising new compound class for treating human malaria is the imidazolopiperazines (IZP) class. IZP compounds KAF156 (Ganaplacide) and GNF179 are effective against Plasmodium symptomatic asexual blood-stage infections, and are able to prevent tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b18290350407667761814a3f37b90a3
https://doaj.org/article/30325ebc8f1440eb95a7ef787cbdca69
https://doaj.org/article/30325ebc8f1440eb95a7ef787cbdca69
Autor:
Nina F. Gnädig, Françoise Benoit-Vical, Romain Coppée, Jérôme Clain, David A. Fidock, Karamoko Niaré, Jean-Michel Augereau, Barbara H. Stokes, Lucie Paloque
Publikováno v:
Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy, 2022, 66 (1), pp.e01320-21. ⟨10.1128/AAC.01320-21⟩
Antimicrobial Agents and Chemotherapy, 2022, 66 (1), pp.e01320-21. ⟨10.1128/AAC.01320-21⟩
International audience; Partial artemisinin resistance, defined in patients as a delayed parasite clearance following artemisinin-based treatment, is conferred by non-synonymous mutations in the Kelch beta-propeller domain of the Plasmodium falciparu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa70ff64915a7d8f74890e13f65a4174
https://doi.org/10.1128/aac.01320-21
https://doi.org/10.1128/aac.01320-21
Autor:
Sachel Mok, Adama Gansané, Rithea Leang, Clark H. Cunningham, Romaric Nzoumbou-Boko, David A. Fidock, Aline Uwimana, Ioanna Deni, Nina F. Gnädig, Barbara H. Stokes, Marian Warsame, Kelly Rubiano, Leila S. Ross, Olimatou Kolley, Kurt E. Ward, Issa M. Souleymane, Eric Legrand, Frédéric Ariey, Philip J. Rosenthal, Josefine Striepen, Samuel J. Smith, Abdunoor M. Kabanywanyi, Judith Straimer, Jade Bath, Kyra A Schindler, Didier Menard, Mathieu Ndounga, Tim J. Anderson, François Nosten, Claudette Ndayikunda, Tomas Yeo, Satish K. Dhingra
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife, eLife Sciences Publication, 2021, 10, pp.e66277. ⟨10.7554/eLife.66277⟩
eLife, 2021, 10, pp.e66277. ⟨10.7554/eLife.66277⟩
eLife
eLife, eLife Sciences Publication, 2021, 10, pp.e66277. ⟨10.7554/eLife.66277⟩
eLife, 2021, 10, pp.e66277. ⟨10.7554/eLife.66277⟩
The emergence of mutant K13-mediated artemisinin (ART) resistance in Plasmodium falciparum malaria parasites has led to widespread treatment failures across Southeast Asia. In Africa, K13-propeller genotyping confirms the emergence of the R561H mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d4652f8546d77e0464272dc94dc4b6
https://ora.ox.ac.uk/objects/uuid:24d02c06-c99a-469c-92f8-1d3ccb074394
https://ora.ox.ac.uk/objects/uuid:24d02c06-c99a-469c-92f8-1d3ccb074394
