Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Nina Engels-Domínguez"'
Autor:
Nina Engels-Domínguez, Elouise A. Koops, Stephanie Hsieh, Emma E. Wiklund, Aaron P. Schultz, Joost M. Riphagen, Prokopis C. Prokopiou, Bernard J. Hanseeuw, Dorene M. Rentz, Reisa A. Sperling, Keith A. Johnson, Heidi I. L. Jacobs
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Background Autopsy work indicates that the widely-projecting noradrenergic pontine locus coeruleus (LC) is among the earliest regions to accumulate hyperphosphorylated tau, a neuropathological Alzheimer’s disease (AD) hallmark. This early
Externí odkaz:
https://doaj.org/article/1a2a23bb5bfe4f028d41e04abb34676d
Autor:
Prokopis C. Prokopiou, Nina Engels-Domínguez, Kathryn V. Papp, Matthew R. Scott, Aaron P. Schultz, Christoph Schneider, Michelle E. Farrell, Rachel F. Buckley, Yakeel T. Quiroz, Georges El Fakhri, Dorene M. Rentz, Reisa A. Sperling, Keith A. Johnson, Heidi I. L. Jacobs
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Older individuals exhibiting diminished function of the locus coeruleus while learning new information show faster cognitive decline that is typical for Alzheimer’s disease.
Externí odkaz:
https://doaj.org/article/064e0e4a05864dea8910777843fb04ad
Autor:
Heidi I.L. Jacobs, John Alex Becker, Kenneth Kwong, Diana Munera, Liliana Ramirez‐Gomez, Nina Engels‐Domínguez, Justin S Sanchez, Clara Vila‐Castelar, Ana Baena, Reisa A. Sperling, Keith A. Johnson, Francisco Lopera, Yakeel T. Quiroz
Publikováno v:
Alzheimer's & Dementia, 19(1), 169-180. Elsevier Science
Introduction Autopsy studies recognize the locus coeruleus (LC) as one of the first sites accumulating tau in Alzheimer's disease (AD). Recent AD work related in vivo LC magnetic resonance imaging (MRI) integrity to tau and cognitive decline; however
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c050e8aac150bf7306f5c007d1070172
https://doi.org/10.1002/alz.12656
https://doi.org/10.1002/alz.12656
Autor:
Nina, Engels-Domínguez, Elouise A, Koops, Prokopis C, Prokopiou, Maxime, Van Egroo, Christoph, Schneider, Joost M, Riphagen, Tarun, Singhal, Heidi I L, Jacobs
Publikováno v:
Neuroscience and Biobehavioral Reviews, 144:104998. Elsevier Science
Primary prevention trials have shifted their focus to the earliest stages of Alzheimer's disease (AD). Autopsy data indicates that the neuromodulatory subcortical systems' (NSS) nuclei are specifically vulnerable to initial tau pathology, indicating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c211a591ae5c8621b8e5603cd5360c2
https://doi.org/10.1016/j.neubiorev.2022.104998
https://doi.org/10.1016/j.neubiorev.2022.104998
Autor:
Prokopis C. Prokopiou, Nina Engels-Domínguez, Kathryn V. Papp, Matthew R. Scott, Aaron P. Schultz, Christoph Schneider, Michelle E. Farrell, Rachel F. Buckley, Yakeel T. Quiroz, Georges El Fakhri, Dorene M. Rentz, Reisa A. Sperling, Keith A. Johnson, Heidi I. L. Jacobs
Publikováno v:
Nature Communications, 13(1):1571. Nature Publishing Group
Animal and human imaging research reported that the presence of cortical Alzheimer's Disease's (AD) neuropathology, beta-amyloid and neurofibrillary tau, is associated with altered neuronal activity and circuitry failure, together facilitating clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0547c34e562fdbadb9afcedff6cbca69
https://doi.org/10.1038/s41467-022-28986-2
https://doi.org/10.1038/s41467-022-28986-2
Autor:
Keith A. Johnson, Kenneth K. Kwong, Julie C. Price, Reisa A. Sperling, Federico d’Oleire Uquillas, Kathryn V. Papp, Georges El Fakhri, Michael J. Properzi, Justin S. Sanchez, Heidi I.L. Jacobs, Marc D. Normandin, John A. Becker, David A. Bennett, Nina Engels-Domínguez, Olivia L. Hampton, Prokopis C. Prokopiou, Dorene M. Rentz
Publikováno v:
Sci Transl Med
Science Translational Medicine, 13(612):eabj2511. American Association for the Advancement of Science
Science Translational Medicine, 13(612):eabj2511. American Association for the Advancement of Science
Several autopsy studies recognize the locus coeruleus (LC) as the initial site of hyperphosphorylated TAU aggregation, and as the number of LC neurons harboring TAU increases, TAU pathology emerges throughout the cortex. By conjointly using dedicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ad2afa65420b253da621447996460e8
https://doi.org/10.1126/scitranslmed.abj2511
https://doi.org/10.1126/scitranslmed.abj2511
Autor:
Prokopis C, Prokopiou, Nina, Engels-Domínguez, Kathryn V, Papp, Matthew R, Scott, Aaron P, Schultz, Christoph, Schneider, Michelle E, Farrell, Rachel F, Buckley, Yakeel T, Quiroz, Georges, El Fakhri, Dorene M, Rentz, Reisa A, Sperling, Keith A, Johnson, Heidi I L, Jacobs
Publikováno v:
Nature communications. 13(1)
Animal and human imaging research reported that the presence of cortical Alzheimer's Disease's (AD) neuropathology, beta-amyloid and neurofibrillary tau, is associated with altered neuronal activity and circuitry failure, together facilitating clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2c35181cb8e8e02a24c3506b8f38e08d
https://pubmed.ncbi.nlm.nih.gov/35659415
https://pubmed.ncbi.nlm.nih.gov/35659415